Dr. Sol-Church is the Co-Director of the INBRE Central Research Instrumentation Core.
The purpose of the Central Research Instrumentation Core is to provide INBRE-affiliated researchers with state-of-the-art instrumentation and highly qualified professional personnel to carry out leading-edge research and thereby improve their capability to secure federal grants.
The mission of the Center is to improve networking, communication, visibility, and performance of the INBRE core facilities. Dr. Sol-Church is also the Director of the Nemours Biomolecular Core Laboratory (BCL) which operates the INBRE microarray core. BCL plays a critical and enabling role to facilitate the development of genetics and genomics based biomedical research by providing services in DNA sequencing, pyrosequencing, DNA fragment analysis, global gene expression, real time and genotyping.The Biomolecular Core Laboratory is operated by two highly trained and dedicated staff: Jennifer Holbrook and Deborah Stabley.
The laboratory is equipped with:
- a Biotage PSQ96 MA Pyrosequencer used for genotyping and epigenetic/methylation studies;
- an Applied Biosystem (ABI) 3130 XL 16 Capillary Genetic Analyzer used primarily for mutation analysis and fragment analysis;
- a 7900 Real-Time PCR System from ABI outfitted with a 384 well block for high throughput genotyping and qPCR analysis;
- a Beckman Biomek 2000 robotic workstation;
- an Affymetrix GeneChip Microarray System (GeneChip Hybridization Oven 640; GeneChip Fluidics Station 450; GeneChip Scanner);
- two Strategene Robocycler Gradient 96 PCR machine;
- a fleet of shared thermocyclers (PE9700, PE9600, and PE2400);
- a Nanodrop ND-1000 spectrophotometer;
- Agilent 2100 Bioanalyzer.
The core’s computer complement includes five PCs and 2 MACs, which are loaded with specialized software controlling instrument’s run and performances. Available stand alone software include: SDS2.1, Sequencher, and MacVector 7.1.1. All computers are either connected to the Nemours or Medsci intranet (or both). Connection to the global web is available on most of the core computers.