Nutrition
Most infants with primordial dwarfism have feeding problems, but it is important that the treating physican lower their expectations of daily growth to at least half that of a typical child.
Small volumes and frequent feeding are typical. Sometimes naso-gastric feeding or g-tube feedings are used.
Brain
Some patients have structural or myelination abnormalities in the brain. Structural abnormalities have included: enlarged ventricles, abnormal gyral patterns and abnormal corpus callosum.
Development
Precocious puberty has been described in girls with breast development as early as 7 and menarche, or the beginning of periods, at 9 years. Boys do not seem to have precocious puberty.