Although the first 18 months are characterized by relatively normal development, beyond this age, Morquio patients tend to decline, especially in proportionate growth and mobility.
Any change in walking ability, endurance, or breathing merits further assessment by a physician to rule out spinal cord compression. Specific neurological symptoms such as tingling or numbness in the arms or legs, weakness, shooting leg or arm pain, or problems controlling bladder/ bowel function should be investigated further.
Considering that eye and teeth problems are especially associated with Morquio Syndrome, ophthalmologic consultation and dental examinations are recommended for early detection and treatment.
Generally all skeletal dysplasias warrant multidisciplinary attention. Regular assessment by an orthopedist, geneticist, pediatrician, dentist, neurologist, and physical therapist will provide the most comprehensive treatment.