CareTalk Blog: Nemours Center for Cancer and Blood Disorders

CareTalk: Blog for Cancer and Blood Disorders

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Lymphoma

Lymphomas are cancers that start in a child's lymphatic system — the part of the body that works with the immune system to help fight infections and diseases.

There are two types of pediatric lymphoma:
  • Non-Hodgkin’s lymphoma (also called NHL, non-Hodgkin’s disease, or just non-Hodgkin’s, for short) is the most common type of pediatric lymphoma. This type of cancer develops when there are too many white blood cells in the lymph nodes, bone marrow, spleen, and other areas. Non-Hodgkin’s lymphoma is usually diagnosed in children between the ages of 7 and 11, but older kids and adults can have it, too.
  • Hodgkin’s lymphoma (also called Hodgkin’s disease) develops when abnormal B cells (called Reed-Sternberg cells) start to form in the lymph nodes, spleen, and other areas of the body. Although associated with progressive swelling in the lymph nodes (or glands), Hodgkin’s lymphoma is often hard to diagnosis because symptoms can seem like the flu. Most kids with Hodgkin’s lymphoma are diagnosed around age 15.
 
Signs and Symptoms of Lymphoma in Children

Each individual child’s symptoms can vary, but common signs and symptoms of pediatric lymphoma may include:

  • swelling (typically where lymph nodes are found such as the neck, chest, abdomen, underarms, and groin areas)
  • fever
  • sore throat
  • bone and joint pain 
  • night sweats
  • fatigue (more tired than usual)
  • sudden and increased weight loss
  • burning and itching skin

IMPORTANT NOTE: These signs and symptoms together or on their own do not automatically mean that a child has lymphoma. Any or all of these could be a sign of something else. And not all need be present to indicate lymphoma or any other kind of cancer.

 
Diagnosing Pediatric Lymphoma

Our pediatric cancer care experts will conduct a complete exam of your child and a medical history evaluation. Other diagnostic tests for pediatric lymphoma may include:

  • X-rays
  • blood and urine tests
  • lymph node biopsy (taking a sample of cells or tissues for examination)
  • CAT scan (which stands for computed tomography) — a painless test that uses a special X-ray machine to take black-and-white pictures of the lungs, heart, blood vessels, airway passages, ribs, and lymph nodes
  • PET scan (which stands for positron emission tomography) — an imaging test that helps doctors see how the organs and tissues inside your child’s body are functioning
  • lumbar puncture (also called a spinal tap – when a thin needle is placed in the lower-back area of the spinal cord so we can take and then examine a sample of spinal fluid)

We know that tests can be scary – for you and your child. Whatever kind of tests your child might need, know that your Nemours pediatric cancer care team will do everything we can to make the experience as comfortable as possible – physically and emotionally. We’ll give sedation or anesthesia as needed and offer support and guidance at every step.

Learn more about what to expect with certain medical tests »

 
Treating Lymphoma in Children

Depending on your child’s age, overall health, extent of the disease, and other factors, pediatric lymphoma treatment may include one or a combination of
the following:

  • chemotherapy
  • radiation therapy   
  • blood or bone marrow transplant (also sometimes called a BMT, BBMT, stem cell transplant, or cord blood transplant)
  • medications/antibiotics
  • blood transfusions
  • surgery
  • antibiotics

At Nemours, we know that getting a cancer diagnosis can be very frightening and overwhelming for your whole family. That’s why Nemours’ board-certified pediatric hematologists-oncologists, specialty nurses, cancer researchers, and other cancer experts are focused on helping not only your child, but your family, too.

From diagnosis to treatment (and beyond) we’ll be here to help guide your family through your lymphoma journey – and to strive and hope, with you, for a better tomorrow.

Non-Hodgkin Lymphoma

A lymphoma is a cancer of the lymphatic system, which is a part of the body's immune system and helps filter out bacteria, viruses, and other unwanted substances.

Most of the time, we're not aware of the inner workings of our lymphatic systems unless the lymph nodes, or glands, become swollen. This often happens during illness — a sign that the lymphatic system is working hard to filter harmful substances out of the body.

About Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma is a disease in which cancer cells form in the lymphatic system and start to grow uncontrollably.

There are several different types of lymphomas. Some involve lymphoid cells (called Reed-Sternberg cells) and are grouped under the heading of Hodgkin lymphoma.

All other forms of lymphoma fall into the non-Hodgkin grouping. The different forms of non-Hodgkin lymphoma are characterized by the malignant growth of white blood cells that live in the lymph nodes, called lymphocytes.

Risk Factors

The exact cause of non-Hodgkin lymphoma is unclear, but doctors have identified some risk factors, such as:

  • having conditions that weaken the immune system, like AIDS (acquired immunodeficiency syndrome)
  • taking immune-suppressing medications after organ transplants
  • exposure to certain viruses, such as Epstein-Barr virus (the virus that usually causes mono)
  • having a sibling with the disease

Although no lifestyle factors have been definitively linked to childhood lymphomas, kids who have received either radiation treatments or chemotherapy for other types of cancer seem to have a higher risk of developing lymphoma later in life.

In most cases of patients with non-Hodgkin lymphoma, doctors are never able to determine a specific cause for the disorder. Not knowing the cause, however, doesn’t change the fact that experts are getting better and better at treating the problem.

Regular pediatric checkups may spot early symptoms of lymphoma in cases where this cancer is linked to the treatments or conditions mentioned above.

Signs and Symptoms

Symptoms of non-Hodgkin lymphoma vary depending on the type of lymphoma and where a tumor is located. Some kids might have stomach pain, constipation, and decreased appetite. Others may have trouble breathing, difficulty swallowing, coughing, wheezing, or chest pain.

Other symptoms can include:

  • painless swollen lymph nodes
  • fever, chills, or night sweats
  • itchy skin
  • weight loss despite eating normally
  • tiredness
  • bone or joint pain
  • recurring infections

Some kids' first symptom is swollen lymph nodes — usually in the neck, armpits, and groin. Of course, swollen lymph nodes do not usually mean cancer — they're most often a sign of a common illness, like an infection. In fact, all of the symptoms of non-Hodgkin lymphoma also can be caused by other conditions, which is why only a doctor can determine what's really wrong.

Diagnosis

After performing a thorough evaluation, which includes a medical history and physical examination, a doctor who suspects non-Hodgkin lymphoma will refer the child to an oncologist, or cancer doctor.

The oncologist may perform a biopsy, or tissue sample, of lymph nodes. During a biopsy, a tiny bit of tissue is removed from the body and sent out to a laboratory for analysis. Depending on the type of biopsy ordered, the patient may be given local anesthesia (where only a part of the body is numbed) or general anesthesia (where the patient is asleep) to ensure there's no pain.

Biopsies used to test for non-Hodgkin lymphoma include:

  • excisional biopsy, in which the skin is opened to remove an entire lymph node
  • incisional biopsy, the removal of only a part of the lymph node
  • bone marrow biopsy, where a needle is used to take samples of the soft tissue found inside a bone
  • fine needle aspiration, in which a very thin needle is used to suction out a small amount of tissue from the lymph node

Other tests used to diagnose non-Hodgkin lymphoma include:

  • blood tests
  • a chest X-ray, a simple procedure in which the person lies on a table while an X-ray machine takes an image of the chest
  • a computerized tomography (CT or CAT) scan, which rotates around the patient and creates an X-ray picture of the inside of the body from different angles
  • an ultrasound, which uses high-frequency sound waves to create pictures of the inside of the body
  • a magnetic resonance imaging (or MRI) scan, which uses magnets and radio waves to allow doctors to see inside the body.
  • a gallium scan, which uses the injection of a material known as gallium to help show tumors and inflammation
  • a bone scan to detect bone changes
  • a positron emission tomography (PET) scan, which can tell the difference between normal and abnormal cells based on metabolic activity

Treatment

Treatment of childhood lymphoma is largely determined by staging. Staging is a way to categorize or classify patients according to how extensive the disease is at the time of diagnosis.

The four stages of lymphoma range from Stage I (cancer involving only one area of lymph nodes or only one organ outside the lymph nodes) to Stage IV (cancer has spread, or metastasized, to one or more tissues or organs outside the lymphatic system). The stage at diagnosis can help doctors choose appropriate treatments and predict how someone with lymphoma will do in the long term.

The most common treatment for non-Hodgkin lymphoma is chemotherapy (medication that kills or stops the growth of cancer cells), though some patients will receive radiation therapy.

Kids who receive very aggressive treatments may undergo bone marrow or stem cell transplants to replace cells damaged by high doses of chemo or radiation. These transplants involve taking the cells from bone marrow or blood that has either been donated or taken from the patient and inserting them into the patient's bloodstream.

In a few special situations (such as high-risk patients or those whose cancer has come back), doctors will use immunotherapy (or biological therapy) to treat non-Hodgkin lymphoma. In immunotherapy, doctors use substances that occur naturally in the body to build up someone's natural resistance to disease. Although these substances occur naturally in the body, the ones used in this procedure are often manufactured in a laboratory.

Side Effects

Children treated with chemotherapy or radiation for non-Hodgkin lymphoma usually experience side effects. Most are temporary — although, as with all medical treatments, each child is unique and experiences side effects differently. The severity of side effects and how long they last depends on the individual and the medicines and treatments used.

The most common short-term side effects of chemo are nausea (although medications can treat this), vomiting, a lowering of blood counts resulting in an increased risk for infection or bleeding, or a flu-like feeling. Some kids feel weak or dizzy after their treatments, or run a fever. Others get sores in their mouths or suddenly don't feel much like eating. It's also common for kids to lose some or all of their hair.

The short-term side effects of radiation can be similar to those of chemotherapy, but usually are more localized, meaning they affect only the area that receives the radiation treatment. Kids can continue to feel side effects for weeks after their treatment ends.

Outlook

Most kids with non-Hodgkin lymphoma are cured. Some with severe disease, however, will have a relapse (reoccurrence of the cancer) that doesn't respond to conventional treatments. For them, bone marrow transplants and stem cell transplants may be performed.

Reviewed by: Jonathan L. Powell, MD
Date reviewed: March 2012