Costello Program

2003 Costello Conference hosted by duPont Hospital

The Costello Program at the Alfred I. duPont Hospital for Children addresses the multiple medical and developmental needs of patients and their families. Our coordinated, multi-disciplinary approach provides:

Evaluation of patients for a possible diagnosis of Costello syndrome
Continuity and coordination of medical care
Collaboration with pediatric subspecialists who are aware of this rare disorder and its associated medical problems
Connection to ongoing research and the most current information available worldwide

What is Costello syndrome?

Costello syndrome is a distinct constellation of congenital physical differences affecting multiple organ systems and developmental delay. First described in medical literature in 1971, its etiology has not yet been determined and no specific diagnostic test is available to confirm the Costello syndrome diagnosis. Therefore this diagnosis is made clinically, based on the medical history and physical findings.

Characteristic findings include but are not limited to severe failure to thrive and feeding problems in early childhood, loose skin with deep creases in the hands, hand and foot positional abnormalities, loose joints and low muscle tone with delayed milestones. During later childhood, short stature, tight Achilles tendons and skin tags may be noted. Cardiac abnormalities can also be part of Costello syndrome.

Since Costello syndrome is very rare, it often takes healthcare providers a long time to establish the diagnosis. Because children with Costello syndrome are at risk for severe medical problems, such as cardiac rhythm abnormalities, hypertrophic cardiomyopathy and tumor development, an earlier diagnosis may allow related medical problems to be identified and treated as soon as possible.

Additional Resources:

Costello Program Brochure

Nemours is committed to keeping children and parents informed of the latest medical information. The division provides a wide variety of pamphlets and articles to assist parents in learning more about their childs condition and treatment. Nemours also suggests the following sources and organizations where parents can obtain additional information:

International Costello Syndrome Support Group