What are the associated medical problems?

• Nutrition- Most infants with primordial dwarfism have feeding problems. Small volumes and frequent feeding are typical. Sometimes naso-gastric feeding or g-tube feedings are needed.
• Brain- About 25% of patients have structural or myelination abnormalities in the brain. Structural abnormalities have included: enlarged ventricles, abnormal gyral patterns and abnormal corpus callosum.
• Development- Precocious puberty has been described in girls with breast development as early as 7 and menarche or the beginning of periods at 9 years. Boys do not seem to have precocious puberty.

• What are the physical characteristics of Primordial Dwarfism?
• How is the diagnosis made?
• What are the associated medical problems?
• What are things to watch out for?
• References