Offered by: Nemours
Location: Orlando, FL; Jacksonville, FL
What is the trial about?
INFANT: Study if one asthma treatment works better than another in young children and if there is something about a child that helps doctors know which treatment would work better.
AVICA: Study if acetaminophen or ibuprofen is the better analgesic-antipyretic for children <5 years old with asthma.
Who can participate?
Children who have asthma and are between 12 and 59 months of age (1 year to almost 5 years old) and are otherwise healthy.
What is involved?
Data will be collected for the AVICA study at the same time as visits for the INFANT study. The INFANT study has 8 scheduled study visits and six scheduled study telephone calls. After the run-in period is complete, the treatment period is 48 weeks long (about 11 months). Most visits will take less than one hour. The first two visits may last longer. The telephone calls will take less than 15 minutes each.
Data collected will include physical examination, medical history, questionnaires, urine sample, nasal mucus, diary completion and blood draw. The blood may be drawn in as many as five small tubes but less than one tablespoon (15 ml) of blood will be taken all together. The blood tests include cell counts, markers of inflammation and features of allergy. These tests will tell us about allergies your child may have and will be used to find out if a blood test can help predict which asthma treatment will work best in young children.
Contact Nemours Clinical Trials
Trial Name: Individualized Therapy for Asthma in Toddlers and Acetaminophen vs. Ibuprofen in Children With Asthma