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Nemours Biomedical Research

(302) 651-6884


Membrane Biology Lab

Nemours Biomedical Research, Delaware

About Membrane Biology Lab

The Nemours Membrane Biology Research Laboratory, one of several pediatric labs located at Nemours/Alfred I. duPont Hospital for Children, performs a wide range of basic and translational research projects related to membrane biology.

Principal Investigator
Ayyappan K Rajasekaran, PhD

Professor, Department of Pediatrics, at Thomas Jefferson University; Adjunct Professor, Materials Science and Engineering, and Affiliated Scientist, Biological Sciences, at the University of Delaware; and Senior Research Scientist, Helen F. Graham Cancer Center at Christiana Care Health System.

Current Research Group
  • Ponniah Selvakumar, PhD, Post doctoral fellow, Studies the role of Myristoyltransferases in leukemia progression and treatment
  • Justin David, Graduate Student, Studying the efficacy of  ionophores for kidney cancer treatment
  • Vinu Krishnan, Graduate student, developing nanotechnology based drug delivery for childhood leukemia
  • Pratima Patil, Graduate student, Mechanisms early stage development of cancer using 3D culture models
  • Sona Lakshme Balasubramaniam, Graduate student, mechanisms of cell-cell adhesion in epithelial cells
  • Tori Owens, Laboratory Assistant, Studies on the mechanisms of Wilms’ tumor progression in children

See Current Research Efforts »

Current Research

We are involved in a wide range of research subjects related to membrane biology.

 
Basic Research
Basic research topics include:
  • Mechanisms of Epithelial to Mesenchymal Transition (EMT) and Mesenchymal to Epithelial Transition (MET)
  • Role of Na,K-ATPase in epithelial tissue biogenesis and cancer
  • Biogenesis of tight junctions and desmosomes
  • Biology of prostate specific membrane antigen
 
Translational Research
Translational research topics include:
  • Drug development and preclinical studies for EMT and MET
  • Nanotechnology based drug delivery for leukemia
  • Targeted drug delivery for solid tumors
  • Studies on soluble biomarkers for cancer and inflammation
 
Current Projects
Some of our current projects include:
  • Nanotherapeutics for childhood leukemia
  • Preclinical and Clinical studies of novel drugs for kidney cancer treatment
  • Three dimensional cell culture models for studying early development of cancer

Membrane Biology Laboratory

Ayyappan K Rajasekaran, PhD

Laboratory Head
(302) 651-6593
araj@medsci.udel.edu

Location:

Nemours/Alfred I. duPont Hospital for Children
Rockland Center 1
1701 Rockland Road
Wilmington, DE 19803

Phone: (302) 651-6593
Fax: (302) 651-4827


Cancer Biomarkers & Therapeutics

At the Nemours Center for Childhood Cancer Research, we’re making great strides in the fight against childhood cancer.
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Clinical Trials

Browse our comprehensive list of clinical trials currently underway at Nemours facilities in Delaware and Florida.
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