Facilities

The NCCCR is equipped with new and advanced technologies in cell and molecular biology research. For live cell imaging, NCCCR has the Leica TCS SP5 and 3I Marianas TIRF systems. Leica TCS SP5 is a spectral laser scanning confocal microscope equipped with a two-scanner system and a full range of lasers from 405 nm to 633 nm as well as an environmental chamber. The system is capable of imaging at a broad range of speeds for all imaging needs including live cell functional imaging and highest resolution structural imaging with multi-channel capabilities. The Intelligent Imaging Innovations (3i) Marianas TIRF system is is a fully integrated work station equipped for both live and fixed cell widefield epifluorescence and TIRF microscopy at high temporal resolution. The cancer center is building facilities for in vivo animal imaging required for cancer research.

The researchers at the facility will have access to the Biomolecular Core for molecular genetics research. The Biomolecular Core Laboratory is a centralized, state-of-the-art facility that offers expertise in molecular genetics and genomics and is directed by Dr. Katia Sol-Church. For information please visit http://medsci.udel.edu/cores/bcl/services.html. The NCCCR members have access to Cell Science and Proteomic Core directed by Dr. Robert Mason. The Cell Science Core is equipped with Class II culture hoods (2), incubators (6), fluorescent and phase contrast microscopes, and associated cell preparative facilities. Confocal microscopic facilities are available in an adjacent laboratory. A Beckman Coulter Epics Altra FACS is available in the nearby Research and Administration building for fluorescent sorting of cells in a sterile environment. The front-end proteomics facility is equipped with large-format 2D gel electrophoresis (12 plate capacity) and several small-format gel systems. A trained staff member is available for spot picking, protein digestion and MALDI plate spotting. A Typhoon phosphorimager and associated software are available for analysis of DIGE labeled 2D gels and other fluorescent samples. Expertise is also available for HPLC analysis.

The NCCCR faculty has access to core facilities for electron microscopy, atomic force microscopy, and advanced proteomic approaches at Delaware Biotechnology Institute. Please visit http://www.dbi.udel.edu/core/sharedfac.html for more information.

The cancer center is in the process of expanding its research facilities and this website will be updated accordingly.