Publications

Ayyappan Rajasekaran, PhD

Rajasekaran S.A., S.P. Barwe, J. Gopal, S. Ryazantsev, E.E. Schneeberger, and Rajasekaran A.K. (2007). Na,K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am J Physiol Gastrointest Liver Physiol 292: G124-G133.

Barwe S.P., S. Kim, S.A. Rajasekaran, J.Bowie, and Rajasekaran A.K. (2007). Janus model of the Na,K-ATPase β-subunit transmembrane domain and its implications in α/β assembly and β-β homo-oligomerization. J Mol Biol. 365:706-714.

Barwe S.P., R.S.Maul, J.J.Christiansen, G. Anilkumar, C.R.Cooper, D.B.Kohn, and Rajasekaran A.K. (2007). Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix. Int J Oncol. 4:899-904.

Cui X., L. Zhang, Rajasekaran A.K., S.Hazra, N.Cacalano. S.M.Dubinett (2007). Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Oncogene 26:4253-4260.

Olson W.C., W.D. Heston and Rajasekaran A.K. (2007). Clinical trials of cancer therapies targeting prostate-specific membrane antigen. RRCT 2:182-190.

Goodman, Jr O.B . S. P Barwe, P. McPherson, J. H. Keen , A.Vasko, D. M. Nanus, N. H. Bander, and Rajasekaran A. K. (2007) . Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol. 5:1199-2003.

Seligson D., Rajasekaran S.A., Yu H., Liu X., Eeva M., Tze S., Ball Jr. W., Horvath S., deKernion J., and Rajasekaran A.K. (2008) Na,K-ATPase α1-subunit predicts survival in renal clear cell carcinoma. J. Urol. 179: 338-345.

Rajasekaran, S.A., K.W. Beyenbach and Rajasekaran A.K.. (2008) Interactions of tight junctions with membrane channels and transporters. Biochim Biophys ACTA, 1778(3):757-69.

Inge, L.J., S.A.Rajasekaran, K.Yoshimoto, P.S.Mischel, W.McBride, E.Landow and Rajasekaran A.K.. (2008) Evidence for a potential tumor suppressor role for Na,K-ATPase β1-subunit. Histol Histopathol 23(4):459-67.

Inge, L.J., S.A. Rajasekaran, S. Ryazantsev, C.M.Ewing, W.Isaacs and Rajasekaran A.K.. α-catenin overrides Src-dependent activation of β-catenin oncogenic signaling (Molecular Cancer Therapeutics, 2008 June; 7(6): 1386-97).

Rajasekaran, S., Christiansen, J.J., Schmid, I.,Ryanzantsev S., Oshima, E., Sakamoto, K., Weinstein, J., Rao, N., Rajasekaran, A.K. (2008). Prostate specific membrane antigen associates with anaphase promoting complex and induces chromosomal instability. (Molecular Cancer Therapeutics 2008: 7(7): 2142-2151).

Rajasekaran, S and Rajasekaran, A.K. (2008). Na,K-ATPase and tight junctions (Frontiers in Bioscience, in press).

Rajasekaran S A. and Rajasekaran A.K. (2008). Epithelial to Mesenchymal Transition, Cancer Encyclopedia (in press).

Reckamp K., B Gardner, R. Figlin, D. Elashoff, K.Krysan, M. Dohadwala, J.Mao, S. Sharma, L.Inge, Rajasekaran A.K., S. Dubinett (2008). Tumor response to combination celecoxib and erlotinib therapy in NSCLC is associated with a low baseline matrix metalloproteinase-9 and a decline in serum soluble E-cadherin (Journal of Thoracic Oncology 2008 Feb; 3(2): 117-24).

Sigrid A. Langhans, PhD

Barwe S.P., Kim S., Rajasekaran S.A., Bowie J.U., and Rajasekaran A.K. (2007) Janus model of the Na,K-ATPase -subunit transmembrane domain: Distinct faces mediate / assembly and - homo-oligomerization. J. Mol. Biol. 365:706-714.

Rajasekaran S.A., Barwe S.P., Gopal J., Ryazantsev S., Schneeberger E.E. and Rajasekaran A.K. (2007) Na,K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 292:G124-G133.

Seligson D., Rajasekaran S.A., Yu H., Liu X., Eeva M., Tze S., Ball W. Jr., Horvath S., deKernion J., and Rajasekaran A.K. (2008) Na,K-ATPase 1-subunit predicts survival in renal clear cell carcinoma. J. Urol. 179: 338-345.

Inge L.J., Rajasekaran S.A., Yoshimoto K., Mischel P.S., McBride W., Landaw E., andRajasekaran A.K. (2008) Evidence for a potential tumor suppressor role for the Na,K-ATPase 1-subunit. Histol. Histopathol. 23: 459-467.

Rajasekaran S.A., Christiansen J.J., Schmid I., Oshima E., Ryazantsev S., Sakamoto K., Weinstein J., Rao N.P. and Rajasekaran A.K. (2008) Prostate specific membrane antigen associates with anaphase promoting complex and induces chromosomal instability. Mol. Cancer Ther. 7: 2142-2151. *with press release

Inge L.J., Rajasekaran S.A., Wolle D., Barwe S.P., Ryazantsev S., Ewing C.M. Isaacs W.B. and Rajasekaran A.K. (2008) -catenin overrides Src-dependenent activation of -catenin oncogenic signaling. Mol. Cancer Ther. 7: 1386-1397.

Rajasekaran A.K. and Rajasekaran S.A. (2008) Epithelial-mesenchymal transition. Manfred Schwab (Editor), Encyclopedia of Cancer, 2nd edition, Springer.

Rajasekaran S.A., Beyenbach K.W., and Rajasekaran A.K. (2008) Interactions of tight junctions with membrane channels and transporters. Biochim Biophys Acta 1778: 757-769.

Barwe S.P., Jordan M.C., Skay A., Inge L., Rajasekaran S.A., Wolle D., Johnson C.L., Fan K., Rozengurt N., Golhaber J.I., Roos K.P. and Rajasekaran A.K. (2009) Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase 1-subunit. J. Cell. Mol. Cardiol. 47: 552-560. * with press release

Rajasekaran S.A.* and Rajasekaran A.K. (2009) Na,K-ATPase and epithelial tight junctions. Front. Biosci. 14: 2130-2148. *corresponding author

Vivanco I., Rohle D., Versele M., Iwanami A., Kuga D., Oldrini B., Dang J., Kubek S., Palaskas N., Hsueh T., Evans M., Mulholland D., Wolle D., Rajasekaran S., Rajasekaran A., Liau L., Cloughesy T., Dikic I., Brennan C., Wu H., Mischel P., Perera T., Millinghoff, I. (2010)  The phosphatase and tensin homolog requlates epidermal growth factor receptor inihibitor response by targeting EGFR for degradation. Proc. Natl. Acad. Sci. 107: 6459-6464.

Rajasekaran S.A.*, Huynh T.P., Wolle D., Espineda C., Inge L., Skay An., Lassman C., Nicholas S.B., Harper J.F., Reeves A.E., Ahmed M.M., Leatherman J.M., Mullin J.M., Rajasekaran A.K. (2010) Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis. Mol. Cancer Ther. 9: 1515-1524.  *co-corresponding author, * with press release

Rajasekaran S.A. (2011) Therapeutic potential of curcumin in gastrointestinal diseases. World J. Gastrointest Pathophysiol 2: 1-14.

Inge L.J., Barwe S.P., D’Ambrosio J., Gopal J.,  Lu K., Ryazantsev S., Rajasekaran S.A., Rajasekaran A.K. (2011)  Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor. Exp. Cell Res. 317: 838-848.

Lee S.J., Krauthauser C., Maduskuie V., Fawcett P.T., Olson J.M., Rajasekaran S.A. (2011) Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. BMC Cancer 11: 144 * with press release.

Altunbas A., Lee S.J., Rajasekaran S.A., Schneider J.P., Pochan D.J. (2011) Encapsulation of Curcumin in Self-Assembling Peptide Hydrogels as Injectable Drug Delivery Vehicles. Biomaterials 32: 5906-5914.

Lee S.J. and Langhans S.A. (2012) Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis. BMC Cancer 12: 44 * with press release.

Robert Mason, PhD

Hassanein, M., Korant, B. D., Lu, G. and Mason, R. W. (2007) Expression of Cathepsin P mRNA, Protein and Activity in the Rat Choriocarcinoma Cell Line, Rcho-1, During Giant Cell Transformation” Placenta, 28, 912-919.

Hassanein, M., Xue, F., Seto, C.T. and Mason, R. W. (2007) “Development of a specific inhibitor for the placental protease, cathepsin P” Arch. Biochem. Biophys., 464, 288-294.

Mason, R.W. (2008) “Emerging Roles of Placental Cathepsins” Placenta. 29, 385-390

Sireesha, G.V., Mason, R.W., Hassanein, M., Tonac, S.,Navarrete Santos, A., Fischer, B., Seshagiri, P.B. (2008) “Role of Cathepsins in Blastocyst Hatching in the Golden Hamster” Mol. Human Reprod. 14, 337-346