Investigators:
- H. Timothy Bunnell, PhD.
- Carolyn Schanen, MD, PhD.
Background
Although current speech research practice is dominated by computer-based analytical aids, much time must be spent manually calibrating the speech models used by computers. Because of the required amount of detailed input necessary on the part of highly experienced speech scientists, speech research is not as efficient or as productive as current technology actually allows. It is possible, though, to overcome this obstacle by adapting computer models to work in the researchers’ favor. Thus, the current research will explore this potential.
Another goal of the present research is to study possible genetic factors in childhood speech disorders of unknown origin (i.e., the delay cannot be caused by deafness, cognitive delays, or physical malformation). Previous studies have shown that genetic areas currently linked with dyslexia may also be associated with speech delay. By simultaneously studying speech production and perception of children with speech delay and of those without speech delay, it may be possible to more accurately identify which areas of the genome act as predictable markers for speech delay. If a genetic test for speech delay is achieved, or assessed even as being possible, the speech therapy needs of future generations of children can be more quickly evaluated and conducted with a conceivably higher success rate.
What we’re doing
We’re currently seeking participant families for the speech genetics research project. Each family must include at least two siblings in the age range of 5-9 years during the course of this study as well as at least one biological parent. One or more children from each family must represent speech delay without known causes. The two children and at least one biological parent must participate in the saliva (DNA) collection process, as well as partake in a genetic interview. For more information on family participation, or to take a participation survey, please visit the Speech Research Lab website.
Soon after a family is confirmed to meet the research participant criteria, a parent will be contacted and an appointment can be scheduled for a visit to the lab. It is there that the project can be explained in detail to the family. A great benefit of a personal meeting between family members and lab staff is that any outstanding questions or concerns regarding the focus, content, procedures, and impact of this important research can be fully addressed.
Once the family is confident in their understanding of the project, participation may begin. Each child participant will be administered several tests, including some that measure speech production and speech perception. We will collect saliva samples from all participating family members so that we can analyze DNA. In addition, each participating parent will be interviewed by a genetic counselor so that we may learn more about family history. Testing will require two visits to our lab (lasting about 2 hours each) for each child. Families who participate will receive compensation after completing all of the necessary interviews and testing.