Blood and Bone Marrow Transplants

Nemours Center for Cancer and Blood Disorders in the Delaware Valley and Florida

Blood and Bone Marrow Transplant Locations

 
Wilmington, Del.

Nemours/Alfred I. duPont Hospital for Children

1600 Rockland Road
Wilmington, DE 19803
Get Map & Directions »
Learn More About This Location »

For Appointments: (800) 416-4441


The pediatric Blood and Bone Marrow Transplant Program at Nemours/Alfred I. duPont Hospital for Children is one of only a handful in the United States that performs autologous and allogeneic transplants accredited by the Foundation for Accreditation of Cellular Therapies (FACT). We’re also recognized by the National Marrow Donor Program (NMDP) as an affiliated center for matched unrelated donor transplants.

Pediatric Blood and Bone Marrow Transplant Program Highlights

Our blood and bone marrow transplantation program highlights include:

  • dedicated staff of board-certified pediatric blood and bone marrow
  • transplantation specialists and experienced transplant nurses
  • onsite biobank/stem cell laboratory for stem cell cryopreservation, storage and infusion
  • advanced treatments and clinical trial participation as part of the Children’s Oncology Group (COG) (the world's largest organization devoted exclusively to pediatric cancer research)
  • specially equipped patient rooms and unit play room for our transplant patients
  • onsite chemotherapy infusion suite and pediatric day therapy suite
    pediatric radiation therapy services through our affiliate, Christiana Care Health System’s Helen F. Graham Cancer Center
  • active Child Life and volunteer program offering play therapy, art therapy and more during treatment
  • compassionate transplant coordinators and social workers who provide treatment education, tips to manage side effects and resources for your child and family
Your Child’s Comprehensive Blood and Bone Marrow Transplant Care Team

In addition to an experienced, compassionate transplant coordinator (a nurse who provides your child and family transition support, education and care coordination), the Delaware Valley’s pediatric blood and bone marrow transplant teams include:

  • hematologists (blood disorder specialists)
  • oncologists (cancer doctors)
  • transplant physicians (stem cell transplant specialists)
  • geneticists (specialists in genetic counseling and testing)
  • immunologists (autoimmune disorder specialists)
  • pathologists (physicians who diagnose diseases by examining body tissues, fluids and organs)
  • radiation oncologists (specialists in radiation therapy treatment)
  • interventional radiologists (physicians who perform image-guided minimally-invasive procedures)
  • behavioral health specialists (psychologists and psychiatrists)
  • registered dieticians (nutrition professionals)
  • hematology-oncology nurses (registered nurses specializing in childhood blood disorders)
  • therapy services (physical therapy, occupational therapy, Child Life)
  • teachers (who work in our on-site school)

For your child’s overall health and wellness, we also prescribe physical medicine and rehabilitation, pain management services, palliative and care (to manage physical symptoms) and integrative medicine therapies (massage, hydrotherapy, biofeedback, yoga, meditation and more).

Support Services for Your Family

Nemours provides an array of support services to help your child and family throughout the entire journey. Our supportive care begins on the very first day we meet, and continues beyond treatment because at Nemours, your child and family become part of our own.

Our services include: 

  • patient and family education
  • mental health counseling
  • support groups
  • survivorship programs
  • transition of care
We Make You Feel Right at Home

At duPont Hospital for Children, we provide an environment where kids and families can find fun and normalcy during long-term hospital stays. Some of our amenities for blood and bone marrow patients and families include:

  • nearby family housing at the Ronald McDonald House of Delaware
  • private patient rooms with ample outdoor lighting and a private bathroom
  • healing gardens
  • kid-friendly indoor play areas designated for children who received a transplant
  • playground for children recovering from a transplant
  • onsite learning and advocacy during the transition back to school
  • exercise equipment for children and their families on the transplant unit
  • weekly town-hall-style meetings to address concerns and answer questions that may come up from living in a communal or hospital-based environment
  • family advisory council of parents who can help you along the way

Learn More About All of Our Nemours Center for Cancer and Blood Disorders Facilities and Services in Delaware »

 
Orlando, Fla.

Nemours Children's Hospital, Orlando

13535 Nemours Parkway
Orlando, FL 32827
Get Map & Directions »
Learn More About This Location »

For Appointments: (407) 650-7715


The Nemours Center for Cancer and Blood Disorders at Nemours Children’s Hospital in Orlando currently refers patients to our Jacksonville, Fla. location for blood and bone marrow transplants.

The pediatric Blood and Marrow Transplant Program in Jacksonville is accredited by the Foundation for Accreditation of Cellular Therapies (FACT) and represents a unique collaboration that includes Wolfson Children’s Hospital, Mayo Clinic in Florida and Nemours Children’s Specialty Care, Jacksonville. The program is one of a handful in the country that performs autologous and allogeneic transplants, and is recognized by the National Marrow Donor Program as an affiliated center for matched unrelated donor transplants.

How Our Pediatric Blood and Marrow Transplantation Collaboration Works
Pediatric Blood and Marrow Transplantation Program Highlights

Together our blood and marrow transplantation program highlights include:

  • dedicated staff of board-certified pediatric blood and bone marrow transplantation specialists and experienced transplant nurses
  • advanced treatments and clinical trial participation as part of the Children’s Oncology Group (COG) (the world's largest organization devoted exclusively to pediatric cancer research)
  • pediatric radiation therapy services provided through our partners,First Radiation Oncology Group (FROG)
  • pediatric proton therapy services provided through the University of Florida Proton Therapy Institute in Jacksonville
  • onsite chemotherapy infusion suite
  • active Child Life and volunteer program offering play therapy, art therapy and more during treatment
  • compassionate transplant coordinators and social workers provide treatment education, tips to manage side effects, and resources for your child and family
Your Child’s Comprehensive Blood and Bone Marrow Transplant Care Team

In addition to an experienced, compassionate transplant coordinator (a nurse who provides your child and family transition support, education and care coordination), Jacksonville's pediatric blood and bone marrow transplant teams include:

  • hematologists (blood disorder specialists)
  • oncologists (cancer doctors)
  • transplant physicians (stem cell transplant specialists)
  • geneticists (specialists in genetic counseling and testing)
  • immunologists (autoimmune disorder specialists)
  • pathologists (physicians who diagnose diseases by examining body tissues, fluids and organs)
  • radiation oncologists (specialists in radiation therapy treatment)
  • interventional radiologists (physicians who perform image-guided minimally-invasive procedures)
  • behavioral health specialists (psychologists and psychiatrists)
  • registered dieticians (nutrition professionals)
  • hematology-oncology nurses (registered nurses specializing in childhood blood disorders)
  • therapy services (physical therapy, occupational therapy, Child Life)
  • teachers (who work in our on-site school)

For your child’s overall health and wellness, we also prescribe physical medicine and rehabilitation, pain management services, palliative and care (to manage physical symptoms) and integrative medicine therapies (massage, hydrotherapy, biofeedback, yoga, meditation and more).

Support Services for Your Family

Nemours provides an array of support services to help your child and family throughout the entire journey. Our supportive care begins on the very first day we meet, and continues beyond treatment because at Nemours, your child and family become part of our own.

Our services include: 

  • patient and family education
  • mental health counseling
  • support groups
  • survivorship programs
  • transition of care

Learn More About All of Our Nemours Center for Cancer and Blood Disorders Facilities and Services in Orlando »

 
Jacksonville, Fla.

Nemours Children's Specialty Care, Jacksonville

807 Children’s Way
Jacksonville, FL 32207
Get Map & Directions »

For Appointments: (904) 697-3789

Hours: Monday–Friday, 8 a.m. to 5 p.m.
Learn More About This Location »


The pediatric Blood and Marrow Transplantation Program at Nemours Children’s Specialty Care, Jacksonville is a unique collaboration with Wolfson Children’s Hospital, Mayo Clinic in Florida and Nemours Children’s Specialty Care, Jacksonville. The program is one of a handful in the country that performs autologous and allogeneic transplants to have been recognized and accredited by the Foundation for Accreditation of Cellular Therapies (FACT) for more than 10 years. We’re also recognized by the National Marrow Donor Program (NMDP) as an affiliated center for matched unrelated donor transplants.

How Our Pediatric Blood and Marrow Transplantation Collaboration Works
Pediatric Blood and Marrow Transplantation Program Highlights

Together our blood and marrow transplantation program highlights include:

  • dedicated staff of board-certified pediatric blood and bone marrow transplantation specialists and experienced transplant nurses
  • advanced treatments and clinical trial participation as part of the Children’s Oncology Group (COG) (the world's largest organization devoted exclusively to pediatric cancer research)
  • pediatric radiation therapy services provided through our partners, First Radiation Oncology Group (FROG)
  • pediatric proton therapy services provided through the University of Florida Proton Therapy Institute in Jacksonville
  • onsite chemotherapy infusion suite
  • active Child Life and volunteer program offering play therapy, art therapy and more during treatment
  • compassionate transplant coordinators and social workers provide treatment education, tips to manage side effects, and resources for your child and family
Your Child’s Comprehensive Blood and Bone Marrow Transplant Care Team

In addition to an experienced, compassionate transplant coordinator (a nurse who provides your child and family transition support, education and care coordination), Jacksonville's pediatric blood and bone marrow transplant teams include:

  • hematologists (blood disorder specialists)
  • oncologists (cancer doctors)
  • transplant physicians (stem cell transplant specialists)
  • geneticists (specialists in genetic counseling and testing)
  • immunologists (autoimmune disorder specialists)
  • pathologists (physicians who diagnose diseases by examining body tissues, fluids and organs)
  • radiation oncologists (specialists in radiation therapy treatment)
  • interventional radiologists (physicians who perform image-guided minimally-invasive procedures)
  • behavioral health specialists (psychologists and psychiatrists)
  • registered dieticians (nutrition professionals)
  • hematology-oncology nurses (registered nurses specializing in childhood blood disorders)
  • therapy services (physical therapy, occupational therapy, Child Life)
  • teachers (who work in our on-site school)

For your child’s overall health and wellness, we also prescribe physical medicine and rehabilitation, pain management services, palliative and care (to manage physical symptoms) and integrative medicine therapies (massage, hydrotherapy, biofeedback, yoga, meditation and more).

Support Services for Your Family

Nemours provides an array of support services to help your child and family throughout the entire journey. Our supportive care begins on the very first day we meet, and continues beyond treatment because at Nemours, your child and family become part of our own.

Our services include: 

  • patient and family education
  • mental health counseling
  • support groups
  • survivorship programs
  • transition of care

Learn More About All of Our Nemours Center for Cancer and Blood Disorders Facilities and Services in Jacksonville »

 
Pensacola, Fla.

Nemours Children's Clinic, Pensacola

5153 N. Ninth Ave.
Pensacola, FL 32504
Get Map & Directions »

For Appointments: (850) 505-4790

Hours: Monday–Friday, 8 a.m. to 5 p.m. (Central Time)
Learn More About This Location »

The Nemours Center for Cancer and Blood Disorders at Nemours Children’s Clinic, Pensacola currently refers patients to our Jacksonville, Fla. location for blood and bone marrow transplants.

The pediatric Blood and Marrow Transplant Program in Jacksonville is accredited by the Foundation for Accreditation of Cellular Therapies (FACT) and represents a unique collaboration that includes Wolfson Children’s Hospital, Mayo Clinic in Florida and Nemours Children’s Specialty Care, Jacksonville. The program is one of a handful in the country that performs autologous and allogeneic transplants, and is recognized by the National Marrow Donor Program as an affiliated center for matched unrelated donor transplants.

How Our Pediatric Blood and Marrow Transplantation Collaboration Works
Pediatric Blood and Marrow Transplantation Program Highlights

Together our blood and marrow transplantation program highlights include:

  • dedicated staff of board-certified pediatric blood and bone marrow transplantation specialists and experienced transplant nurses
  • advanced treatments and clinical trial participation as part of theChildren’s Oncology Group (COG) (the world's largest organization devoted exclusively to pediatric cancer research)
  • pediatric radiation therapy services provided through our partners,First Radiation Oncology Group (FROG)
  • pediatric proton therapy services provided through the University of Florida Proton Therapy Institute in Jacksonville
  • onsite chemotherapy infusion suite
  • active Child Life and volunteer program offering play therapy, art therapy and more during treatment
  • compassionate transplant coordinators and social workers provide treatment education, tips to manage side effects, and resources for your child and family
Your Child’s Comprehensive Blood and Bone Marrow Transplant Care Team

In addition to an experienced, compassionate transplant coordinator (a nurse who provides your child and family transition support, education and care coordination), Jacksonville's pediatric blood and bone marrow transplant teams include:

  • hematologists (blood disorder specialists)
  • oncologists (cancer doctors)
  • transplant physicians (stem cell transplant specialists)
  • geneticists (specialists in genetic counseling and testing)
  • immunologists (autoimmune disorder specialists)
  • pathologists (physicians who diagnose diseases by examining body tissues, fluids and organs)
  • radiation oncologists (specialists in radiation therapy treatment)
  • interventional radiologists (physicians who perform image-guided minimally-invasive procedures)
  • behavioral health specialists (psychologists and psychiatrists)
  • registered dieticians (nutrition professionals)
  • hematology-oncology nurses (registered nurses specializing in childhood blood disorders)
  • therapy services (physical therapy, occupational therapy, Child Life)
  • teachers (who work in our on-site school)

For your child’s overall health and wellness, we also prescribe physical medicine and rehabilitation, pain management services, palliative and care (to manage physical symptoms) and integrative medicine therapies (massage, hydrotherapy, biofeedback, yoga, meditation and more).

Support Services for Your Family

Nemours provides an array of support services to help your child and family throughout the entire journey. Our supportive care begins on the very first day we meet, and continues beyond treatment because at Nemours, your child and family become part of our own.

Our services include: 

  • patient and family education
  • mental health counseling
  • support groups
  • survivorship programs
  • transition of care

Learn More About All of Our Nemours Center for Cancer and Blood Disorders Facilities and Services in Pensacola »

About Pediatric Blood and Bone Marrow Transplants

Brayton was diagnosed with hemophagocytic lymphohistiocytosis (HLH) when he was 4 months old and received a blood and bone marrow transplant as part of his treatment.

Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among largest and most widely respected in the United States — and across the globe. Along with our renowned oncologists (cancer doctors), hematologists (blood specialists) and researchers, we rank among the very best in the country for both pediatric orthopedics and cancer care (U.S. News & World Report named Nemours/Alfred I. duPont Hospital for Children one of the “Best Hospitals”).

Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children — both malignant and benign.


How Pediatric Blood and Bone Marrow Transplants Work

Blood has three main cell types: red blood cells (which carry oxygen), white blood cells (which fight infection) and platelets (which clot the blood). New blood cells (called “stem cells”) begin in the bone marrow — the red spongy material found inside the bones — and are released to the bloodstream when mature.

A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases.

Treating Pediatric Cancers and Blood Disorders

A blood and bone marrow transplant procedure (also called “stem cell transplant”) treat childhood cancers and blood disorders including:


Treating Nonmalignant Bone Marrow and Immune System Disorders

In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation.

Some of the nonmalignant conditions we treat include:
  • inherited bone marrow failure syndromes (Fanconi anemia, Diamond Blackfan anemia)
  • primary (inherited) immune disorders (severe combined immunodeficiency, Wiskott-Aldrich syndrome, leukocyte adhesion deficiency)
  • metabolic (lysomomal) storage diseases (Hurler syndrome, metachromatic leukodystropy, Krabbe disease, or “globoid leukodystrophy”)

Types of Blood and Bone Marrow Transplants in Children

There are three main types of pediatric blood and bone marrow transplant procedures based on who donates the healthy stem cells.

Autologous Bone Marrow Transplant

When the child is the donor, it’s called an “autologous bone marrow transplant” (or “autologous bone marrow rescue”). Healthy stem cells are either harvested from the child’s own bone marrow intravenously (“IV”), or collected from the child’s circulation (called “peripheral blood or apheresis”) and then reinserted after intensive treatment such as chemotherapy and/or radiation therapy for childhood cancers and blood disorders.  The primary goal of an autologous bone marrow transplant is to “rescue” a child from the effects of very high doses of chemotherapy.


Allogeneic Bone Marrow Transplant

When a parent, sibling or unrelated person donates genetically matched stem cells, it’s called an “allogeneic bone marrow transplant.” Similar to an autologous bone marrow transplant, a donor’s healthy stem cells are harvested from bone marrow or collected from peripheral blood.  
Nemours is recognized by the National Marrow Donor Program (NMDP) as an affiliated center for matched unrelated donor transplants, and by many insurance providers as a Center of Excellence.


Umbilical Cord Blood Transplant

When stem cells are taken from a newborn’s umbilical cord, it can be frozen and stored in a blood bank for a cord blood transplant. These stem cells are particularly effective because they mature quickly and are less likely to cause severe complications such as graft-host diseases.

What to Expect With a Pediatric Blood and Bone Marrow Transplant Procedure

Pediatric blood and bone marrow transplants require very specialized care from the first visit and throughout treatment, recovery and beyond. Transplants typically take up to three weeks for planning and preparation, and six weeks of inpatient hospital care in special blood and bone marrow transplant units staffed by highly trained physicians and nurses.

About the Transplant Process

The process differs depending on the type of pediatric blood and bone marrow transplant procedure, the condition we’re treating and other factors, but you generally can expect the following:

  • planning (consultation with your team, physical examination, medical testing and donor match)
  • conditioning (includes chemotherapy and/or radiation therapy to treat the disease and make room for healthy stem cells)
  • transplantation (stem cells are given intravenously, like a blood transfusion, while your child watches TV, plays games, creates art or works with Child Life specialists)
  • engraftment (occurs when stem cells mature and begin to produce blood cells, which can take two to four weeks)
  • recovery (includes a month of inpatient hospital monitoring to anticipate or treat side effects or complications that may arise as the immune system strengthens)
  • transition (help transitioning your child and family throughout the process and from hospital care to home care)
  • follow-up (includes maintaining frequent outpatient or inpatient follow-up care during the crucial first 100-day post-transplant mark, and also longer term)

Complications of Blood and Bone Marrow Transplants in Children

Blood and bone marrow transplants significantly impact the immune system which increases the risk for infections and other complications that can be severe and life-threatening. It can take months or years for the immune system to recover entirely, so close monitoring is crucial.

At the Nemours Center for Cancer and Blood Disorders, we have the preventive measures, medicines, innovative medical therapies and support programs in place to help your child and family manage and treat possible issues after a transplant, including:

  • side effects during transplantation (e.g., nausea, hypertension, hives, chills, fever, pain)
  • graft-versus-host disease (when the immune system attacks the transplanted stem cells causing fever, rash, diarrhea, respiratory problems, decreased organ function)
  • graft failure (occurs when the body rejects the new stem cells)
    anemia or thrombocytopenia (due to low blood counts)
  • respiratory problems (due to infections, fluid overload or graft-versus-host disease)
  • veno-occlusive disease (or “VOD,” when blood vessels that serve the liver become damaged, causing organ swelling and damage)

Appointments & Referrals

Delaware, Pennsylvania & New Jersey

(800) 416-4441


Florida
Jacksonville Area

(904) 697-3789

Orlando Area

(407) 650-7715

Pensacola Area

(850) 505-4790

Learn About Our Locations »


International
Patients

+1 (302) 651-4993

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See how our comprehensive care and research impact the children and families we treat: