Why Choose Us

Find out what makes our comprehensive, stellar cancer and blood disorders care for kids so special. Learn More »

Soft Tissue Sarcomas

Nemours Center for Cancer and Blood Disorders in the Delaware Valley and Florida

Locations & Doctors Who Treat Soft Tissue Sarcomas

 
Delaware

Wilmington

Nemours/Alfred I. duPont Hospital for Children

1600 Rockland Road
Wilmington, DE 19803
Get Map & Directions »
Learn More About This Location »

For Appointments: (800) 416-4441

Doctors Who Treat Soft Tissue Sarcomas at This Location

 
New Jersey

Voorhees

Nemours duPont Pediatrics, Voorhees

443 Laurel Oak Road
Therapy Services (Suite 200)
Pediatric Specialty Services (Suite 230)
Voorhees, NJ 08043
Get Map & Directions »

For Appointments: (800) 416-4441

Hours: Fourth Friday each month; 9 a.m. to 4 p.m.
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location

To find out which providers serve this location, please call the main number above.
 
Pennsylvania

Philadelphia

Nemours duPont Pediatrics, Philadelphia

833 Chestnut St. E., Suite 300
Philadelphia, PA 19107
Get Map & Directions »

For Appointments: (800) 416-4441

Hours: Monday–Friday: 8 a.m. to 5 p.m.
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location


Lancaster

Nemours duPont Pediatrics, Lancaster

2128 Embassy Drive, Suite A
Lancaster, PA 17603
Get Map & Directions »

For Appointments: (800) 416-4441

Hours: Hours vary; please call
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location

 
Florida

Orlando

Nemours Children's Hospital, Orlando

13535 Nemours Parkway
Orlando, FL 32827
Get Map & Directions »
Learn More About This Location »

For Appointments: (407) 650-7715

Doctors Who Treat Soft Tissue Sarcomas at This Location


Nemours Children's Specialty Care, Orlando

1717 S. Orange Ave.
Orlando, FL 32806
Get Map & Directions »

For Appointments: (407) 650-7715

Hours: Monday–Friday, 8 a.m. to 5 p.m.
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location

To find out which providers serve this location, please call the main number above.

Melbourne

Nemours Children's Specialty Care, Melbourne

1270 N. Wickham Road
Melbourne, FL 32935
Get Map & Directions »

For Appointments: (407) 650-7715

Hours: Monday–Friday: 8 a.m. to 5 p.m.
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location

To find out which providers serve this location, please call the main number above.

Jacksonville

Nemours Children's Specialty Care, Jacksonville

807 Children’s Way
Jacksonville, FL 32207
Get Map & Directions »

For Appointments: (904) 697-3789

Hours: Monday–Friday, 8 a.m. to 5 p.m.
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location


Pensacola

Nemours Children's Specialty Care, Pensacola

5153 N. Ninth Ave.
Pensacola, FL 32504
Get Map & Directions »

For Appointments: (850) 505-4790

Hours: Monday–Friday, 8 a.m. to 5 p.m. (Central Time)
Learn More About This Location »

Doctors Who Treat Soft Tissue Sarcomas at This Location

About Soft Tissue Sarcomas

Marissa was diagnosed with stage 4 alveolar rhabdomyosarcoma, a rare soft tissue cancer when she was 17 years old.

Childhood soft tissue sarcomas (a subtype of sarcoma cancers) occur when cancer cells grow into the connective tissues that support the body, such as muscles, nerves, fat cells, tendons, lining of the joints and blood and lymph vessels. About 900 children are diagnosed each year with soft tissue sarcomas in the United States, which represents 3 percent of all childhood cancers and 1 percent of malignant cancers in children.

Our renowned oncologists, hematologists and researchers at the Nemours Center for Cancer and Blood Disorders (a Children’s Oncology Group member institution) work together to diagnose and treat many different types of soft tissue sarcoma found in children, teens and young adults.


Types of Soft Tissue Sarcomas We Treat

Soft tissue sarcomas can grow anywhere in the body, most commonly in the tissue around the limbs (arms or legs), shoulders, torso and the abdomen. The cause is unknown, however, some studies suggest they may be linked to other cancers and related to some inherited diseases such as Li-Fraumeni syndrome (disorder that increases the risk for developing certain cancers) and neurofibromatosis (a neurocutaneous syndrome).

Rhabdomyosarcomas (RMS)

Rhabdomyosarcomas represent the most common soft tissue sarcoma in children under age 15. These tumors grow into the immature (undeveloped) cells that make up the striated (skeletal) muscles, and are most often found in the head and neck, as well as the urinary or reproductive organs, arms or legs, torso and chest and pelvic areas. Symptoms of childhood rhabdomyosarcoma vary depending on the type and location in the body. Rhabdomyosarcomas are diagnosed in childhood and late teens/early adulthood.

 
Types of rhabdomyosarcomas
  • embryonal rhabdomyosarcomas (most common type that includes botryoid and spindle tumors mainly found in the head and neck and urinary and reproductive organs)
  • alveolar rhabdomyosarcomas (aggressive type that’s commonly found in the arms, legs or torso)
  • undifferentiated embryonal rhabdomyosarcoma of the liver (very rare type that starts in the liver)
  • pleomorphic and undifferentiated rhabdomyosarcomas (rarest type that’s also found in the arms, legs or torso)

Other Types of Childhood Soft Tissue Sarcomas We Treat

  • desmoid tumors (also called “aggressive fibromatosis,” forms in fibrous tissues)
  • desmoplastic small round cell tumors (aggressive masses primarily found in the abdomen, but can occur in the lymphatic, gastrointestinal and urinary/reproductive systems)  
  • fibrosarcoma (forms in the tissues of the tendons and ligaments)
  • leiomyosarcoma (a smooth muscle tumor commonly found in the gastrointestinal tract)
  • liposarcoma (develops in fat tissue)
  • neurofibrosarcoma (also called “malignant fibrous histiocytoma,” found in the fibrous tissue in the legs)
  • peripheral nerve sheath tumor (develops in the cells that wrap around the nerves)
  • synovial cell sarcoma (found in tissue surrounding joints in the arms or legs, commonly the knee)

Diagnosing Soft Tissue Sarcomas in Children

Signs & Symptoms of Soft Tissue Sarcomas

Symptoms of childhood soft tissue sarcomas vary depending on their location. They may cause a painless lump or swelling at the tumor site, or result in soreness or difficulty walking or using the arm. Soft tissue sarcomas (like rhabdomyosarcoma) are difficult to diagnose.


Testing & Evaluations

If your child has a possible soft tissue sarcoma, Nemours’ experienced cancer care team works together to appropriately diagnose and grade the sarcoma through a variety of tests and procedures, including:

  • thorough physical examination and medical history
  • blood tests 
  • medical imaging (X-ray, MRI, PET scan, MIBG scan)
  • diagnostic biopsy (via surgery or minimally invasive interventional radiology)

Treating & Caring for Children With Soft Tissue Sarcomas

Your Child's Comprehensive Soft Tissue Sarcomas Care Team

If  we discover a soft tissue sarcoma, our multidisciplinary (collaborative) team plans the most effective treatment personalized to your child’s needs. 

In addition to an experienced, compassionate cancer coordinator (a nurse who provides your child and family support, education and care coordination), Nemours’ pediatric cancer teams include: 

  • oncologists (cancer specialists)
  • hematologists (specialists in blood disorders)
  • surgeons (general or specialized)
  • pathologists (diagnose diseases by examining body tissues, fluids and organs)
  • geneticists (perform genetic counseling and testing)
  • radiologists (diagnose diseases through medical imaging)
  • radiation oncologists (specialists in radiation therapy treatment)
  • interventional radiologists (perform image-guided minimally-invasive procedures)
  • behavioral health specialists (psychologists and psychiatrists)
  • registered dietitians (nutrition specialists)
  • oncology nurses (registered nurses specializing in cancer)  

Your care team is here to provide your family with ongoing support and follow-up. We always include you in the entire process, because we truly believe in the healing power of families and that you know your child best. 

Learn More About Nemours’ Pediatric Cancer Care Teams in Your Area »


Innovative Childhood Soft Tissue Sarcoma Treatment at Nemours

Treating soft tissue sarcomas, like rhabdomyosarcoma in children, depends on the tumor location, its aggressiveness and other factors. Nemours offers advanced and innovative childhood cancer treatments and approaches (called “modalities”) not available at other children’s hospitals. We may use one or a combination of modalities that include:

  • surgery (removal of a portion or all of a tumor) 
  • chemotherapy (cancer-killing medicines)
  • radiation therapy (external beam, brachytherapy)
  • proton therapy (advanced radiation therapy)
  • immunotherapy (stimulating the immune system to destroy or reject tumors)
  • targeted drug therapies (targets genetic abnormalities)
For your child’s overall health and wellness, we also prescribe:

Learn More About Pediatric Cancer Treatment at Nemours »

Additional Resources & Support for Families

 
Nemours Support Services

Dealing with childhood cancer is difficult for your child and family. But you don’t have to go through it alone. Nemours provides an array of support services that begin on the very first day we meet, and continues throughout your journey because at Nemours, your child and family become part of our own. 

Our services include: 
  • patient and family education
  • social work
  • mental health counseling
  • Child Life services
  • survivorship programs
  • support groups
 
Informative Articles & Videos for Parents From Nemours’ KidsHealth
 
Trusted National Soft Tissue Sarcoma Resources

American Childhood Cancer Organization — Soft Tissue Sarcomas: This site provides a wealth of information and support resources for children and teens with cancer. 

National Cancer Institute — Soft Tissue Sarcomas: The institute website offers information about soft tissue sarcoma treatments, drugs, clinical trials and publications from the National Institute of Health.

Appointments & Referrals

Delaware, Pennsylvania & New Jersey

(800) 416-4441


Florida
Jacksonville Area

(904) 697-3789

Orlando Area

(407) 650-7715

Pensacola Area

(850) 505-4790

Learn About Our Locations »


International
Patients

+1 (302) 651-4993

Our Goal: A Better Tomorrow

At the Nemours Center for Cancer and Blood Disorders, we strive to maximize every child's quality of life — today and for many tomorrows. Watch Video »

Top-Notch Cancer Research

We bring the latest scientific advances from the laboratory bench to the bedside to improve care and strive for a cure. Watch Video »