If your child’s been referred to Nemours for a possible diagnosis of skeletal dysplasia (such as achondroplasia), you’ve come to the right place. We’re one of the foremost health care systems in the world for skeletal dysplasia and dwarfism diagnosis and treatment — offering comprehensive medical and surgical expertise spanning multiple fields.
The skeletal dysplasias are a group of conditions characterized by abnormalities in the growth, development, shape, or integrity of the bones and cartilage. They can lead to a wide variety of medical problems, but the most common feature among them is dwarfism (defined as having a final adult height below 4' 10").
About one out of every 10,000 babies has dwarfism. Most skeletal dysplasias result from a spontaneous genetic mutation at or before conception. Children with skeletal dysplasias have multiple medical and social needs, many of which are unique to their condition.
Common types of skeletal dysplasia include:
- Campomelic Dysplasia
- Cartilage Hair Hypoplasia
- Diastrophic Dysplasia
- Ellis-Van Creveld Dysplasia
- Kniest Dysplasia
- Metatropic Dysplasia
- Morquio Syndrome
- Multiple Epiphyseal Dysplasia
- Primordial Dwarfism
- Spondylo-epiphyseal Dysplasia
- Thanatophoric Dysplasia
Nemours/Alfred I. duPont Hospital for Children, Wilmington
Locations & Doctors
For Appointments: (302) 651-5916
For Information: (302) 651-4181 (Genetics) | (302) 651-6326 (Orthopedics)
Seeing Multiple Specialists?
Our Patient Navigators can help schedule multiple appointments on the same day at the same location.
Other Members of the Team:
- Mary Ellen Little, BSN, RN
- Andrea Schelhaas, MS, LCGC
- Karen Turner, MSPT
- photo ID
- medical and pharmacy insurance cards
- preferred pharmacy name and phone number
- names and dosage of all medications, including over-the-counter medication, your child is currently taking
- guardianship and custody papers, if a legal guardian rather than a parent accompanies your child
- Patient Presents Without Legal Guardian (PDF)
English | Spanish
Note: A parent or legal guardian must be with a child for a first visit.
Resources for Patients & Families
Many pediatricians and obstetricians lack the experience to diagnose and care for skeletal dysplasias. That's why more than 250 short-statured children from around the globe come to Nemours/Alfred I. duPont Hospital for Children each year. Here, they get recommendations from leading experts at a world-class, state-of-the-art facility that treats children with skeletal dysplasia from both a genetic and orthopedic perspective.
Only about a half-dozen clinics in the country treat children with skeletal dysplasia. At duPont Hospital for Children, our reputation for diagnosing and treating even the toughest cases has made us a favorite among families. Parents tout our program in online forums for families of little people, our physicians frequently appear as experts in the media, and our patients come from all over the globe to see us.
Here you’ll find doctors, counselors, nurses, and staff who are uniquely qualified and share a strong commitment to the long-term health and well-being of your child. As a team, we work together to maximize your child’s mobility, correct deformity, and prevent future complications. If your child has complex medical and surgical needs, we have the experienced health professionals and well-equipped facilities to meet them.
Learn more about Dr. Mackenzie and how skeletal dysplasia is treated at duPont Hospital for Children in this informative interview.
The Skeletal Dysplasia Appointment Process
Your child’s initial visit to our Skeletal Dysplasia Program usually begins with a diagnostic visit through our Genetics division and our world-renowned Genetics expert in skeletal dysplasia, Dr. Michael Bober. These visits are quite comprehensive and can take 1-2 hours to complete. They’re also often coordinated with the Department of Orthopedics, headed by the equally world-renowned Dr. William Mackenzie, an Orthopedics expert in skeletal dysplasia.
During your visit, we’ll:
- obtain a thorough medical history and a three-generation family
- review your child’s old medical records and previously obtained X-rays
- perform a physical examination, including detailed body measurements
- assess ranges of joint motions (how much each joint can move) and the relative length of the limb segments
Depending upon this evaluation, we may need to do some additional forms of testing, which are generally painless and can include:
- radiological tests: medical imaging technologies such as X-ray, ultrasound, CT (computed tomography), PET (positron emission tomography), and MRI (magnetic resonance imaging)
- biochemical tests: which measure the amount or activity of a particular enzyme or protein in a sample of blood or urine or other tissue
- molecular tests: which assess biological makeup at the genetic level to confirm a child’s clinical diagnosis, and may help provide information as to which treatment options would be the most effective in certain individuals
To make a specific skeletal dysplasia diagnosis in an individual child, we look at all of the data we gather as a whole. We can often make a diagnosis in our initial evaluation. But some skeletal dysplasias can take time to diagnose, so we may need to do another comprehensive evaluation.
Your Coordinated Skeletal Dysplasia Care Team
It's important to know that skeletal dysplasias can evolve and change with time. Once we’ve diagnosed a specific type, we’ll tailor the treatment and management strategies to meet the needs of your child and your family. Some children require appointments with a number of specialists from different departments and multiple surgical procedures.
To make this process a little easier for you and your child, we’ll try to coordinate these appointments and make them as convenient as we can. And, to help make your child’s medical or surgical experience as comfortable as possible, we’ll also provide emotional and psychosocial support and genetic counseling services.
In the Genetics clinic, we follow children at approximately six-month intervals until 6 years old. Then visits are typically spaced yearly. Orthopedics will make follow-up determinations based upon the most recent evaluation.
We understand that arranging travel and multiple appointments can be difficult, so we structure our program so that your family can come and see our physicians and any other specialists here, all on a single day.
Making You Feel Welcome
One of the things parents appreciate most about our skeletal dysplasia care is our location at duPont Hospital for Children — located amid a beautiful park-like setting of huge oaks and inviting green lawns.
You’ll also find:
- free parking (or $5 valet parking)
- kid-friendly waiting areas
- little red wagons (available for escorting your young children)
- café and cafeteria
- on-site pharmacy
- Family Resource Center (with private sleeping rooms, a library, showers, kitchenette, laundry room, and business center)
- Ronald McDonald House of Delaware (right across the street from
When your child's treatment requires surgery or an overnight hospital stay, we’ll help make your family’s experience as easy and stress-free as possible.
Whatever kind of skeletal dysplasia diagnosis and treatment you’re facing, know that we’ll do whatever it takes to give your child the very best, most compassionate treatment possible.
We treat every child as we would our own — your child, our promise.