As an integral part of your fellowship experience, you’ll receive thorough training in research as it relates to the fields of gastroenterology, hepatology and nutrition. The research component will focus primarily on scholarly activities during the first year and either basic science research or clinical projects during the second and third years.

Scholarly Activities

Training in the scholarly experience begins in the first year of the fellowship and continues throughout your training. You’ll develop the full range of requisite skills for research, from project design to completion and presentation to our scholarship oversight committee, in accordance with American Board of Pediatrics certification requirements.

GI Research Lab

Our state-of-the-art GI Research Lab, located on the campus of Nemours Children’s Hospital, Delaware support fellow research activities. This one of kind program provides a designated research team to assist fellow research activities. The team works with fellows and their clinical mentors to support their research projects including bench work, funding core lab service, initial study designing, data analyzing and methods writing for publication.

• Evaluation of PH Interferference and Accuracy of Pancreatic Enzyme Activity by Direct Pancreatic Function Testing. Jonathan Beri, Heidi Hagerott, Zhaoping He, Zarela Molle-Rios.

Active Research

Your second and third years will include more hands-on work in either basic science research or clinical projects. You’ll use knowledge gained in the first year to design and execute a study, from concept to completion and presentation, under the supervision of one of our faculty members.

Completed Research

• Comparison of the gut microbiota composition in Caucasian Hispanic and Caucasian non-Hispanic children with and without obesity (David Garcia, Mathew DiGuglielmo, Zarela Molle-Rios)
• Clinical Outcomes of Methotrexate Binary Treatment With INfliximab or Adalimumab in PracticE(COMBINE) — With Improve Care Now.
• Personalized Research on Diet in Ulcerative Colitis and Crohn’s Disease PRODUCE — With Improve Care Now.
• A Phase 4, Multicenter, Open-label Study of Serum Infliximab Concentrations and Efficacy and Safety of Dose Escalation in Pediatric Patients With Inflammatory Bowel Disease - “ADAPT”. PI Zarela Molle Rios.
• Immunohistochemistry Expression of Cytokines for Diagnosing Eosinophilic Esophagitis, Proton Pump Inhibitor-Responsive Eosinophilic Esophagitis, and Gastroesophageal Reflux in Pediatric Patients. (Shaida Nasiri and Molle Rios)
• The Role of Guanylyl Cyclase C and Its Ligands in Pediatric Obesity: A Prospective Study to Measure the Level of an Intestinal Hormone (Uroguanylin) in Response to a Meal Eaten by Adolescents to Evaluate the Effect on Appetite. (Dr. DiGuglielmo)
• The Role of Guanylyl Cyclase C and Its Ligands in Pediatric Obesity: A Retrospective Study in Tissue Protein Expression Differences of Guanylyl Cyclase C, a Gut Enzyme, and Its Ligands Guanylin and Uroguanylin, Between Obese and Normal Weight Adolescents. (Dr. DiGuglielmo)
• Serological Markers in Children With Celiac Disease and non-Celiac Disease: A Retrospective Study (Dr. Del Rosario and Dr. He).
• Open-Label Safety and Efficacy Study of Reslizumab (CTX55700) for the Treatment of Pediatric Subjects With Eosinophilic Esophagitis Who Completed Study RES-5-0002 
• Complementary and Alternative Medicine (CAM) Use in Pediatric Irritable Bowel Syndrome and Functional Dyspepsia (a pilot study).
• Impact of Premedication With Steroids on Formation of Antibodies to Infliximab and Infusion Reactions in Pediatric Inflammatory Bowel Disease (IBD). (Dr. Gjikopulli and Dr. Molle-Rios)
• Difference in the Frequency of Alpha-1-Antitrypsin Phenotype Between Children With Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis (NAFLD/ NASH) and Normal Population. (Dr. Maheshwari and Dr. Furuya)
• Retrospective Analysis of the Correlation Between Fecal Calprotectin Levels and Inflammatory Bowel Disease (IBD) Activity.
• Evaluation of Gastroesophageal Reflux by Detecting Gastric Pepsin A in Salivary Swabs: Correlating With Impedance/pH Monitoring. (Dr. Al-Atrash and Dr. Molle Rios)
• Effect of Proactive Infliximab Concentration Monitoring on Clinical Remission in Pediatric Inflammatory Bowel Disease (IBD). (Dr Gijkopulli and Dr Molle Rios)

In Process

• Immunohistochemistry Expression of Cytokines for Distinguishing Eosinophilic Esophagitis from Eosinophilia due to Inflammatory Bowel Disease. A Pilot Study Samantha Butzke Zarela Molle Rios.
• Role of Oncostatin-M in Anti-TNF Refractory Inflammatory Bowel Disease (Jennifer Ezirike, Dr. Molle Rios, Dr. John Beri and Dr. He)

Clinical Trials

• A Phase 3 Study of the Efficacy, Safety and Pharmacokinetics of Ustekinumab as Openlabel Intravenous Induction Treatment Followed by Randomized Double-blind Subcutaneous Ustekinumab Maintenance in Pediatric Participants with Moderately to Severely Active Ulcerative Colitis CNTO1275PUC3001 will enroll in 2021.
• An Open Label Addendum to the AMAM adult study to Assess Efficacy and Safety of Mirikizumab in the Induction and Maintenance of Remission in Adolescents (15 to <18 years of age) with Moderately to Severely Active Crohn’s Disease (CD) will enroll in 2021.
• FREE A food additive removal diet for pediatric Eosinophilic Esophagitis In collaboration with Nemours Orlando and Seattle Children’s Hospital — Enrolling patients

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