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Anilkumar Gopalakrishnapillai, PhD
Research Scientist
Biography
Anil Gopala, Ph.D. is Research Scientist and head the Cancer Stem Cell Laboratory at Nemours Center for Childhood Cancer Research. Anil obtained his Ph.D. in molecular biology and biochemistry from Indian Institute of Science, India. As a postdoctoral fellow in tumor biology at the University of California, Los Angeles, Anil's work focused on identifying the role of prostate specific membrane antigen in prostate cancer progression. His work was funded by the Postdoctoral Traineeship Award from Department of Defense. Before being part of Nemours, Anil headed a laboratory focusing on identifying regulators of glucose transporter, GLUT4, and their genetic association with type II diabetes. His laboratory identified STRA6 (stimulated by retinoic acid receptor 6) gene as a novel regulator of glucose metabolism on the basis of its genetic association with type 2 diabetes in Indian population. His team also identified several natural products such as gallic and ellagic acid as glucose uptake stimulators in adipocytes and muscle cells. Anil's research was supported by various RO1 equivalent extramural public funding. Dr. Anil's current focus is on understanding the biology of pediatric Acute myeloid leukemia in general and specifically interested in those seen among down syndrome children (DS-AML). He uses a combination of induced pluripotent stem cells and CRISPR/Cas9 technologies to model the various subtypes of DS-AML and also develop several patient derived xenograft models. These models will be used for preclinical testing and study the initiation and progression of the leukemia. His lab also focuses on understanding role of cancer stem cells in engineering the niche for the favorable existence of cancer cells. His Lab is currently supported by Moseley foundation and several other intra and extramural funding.
Education & Training
Medical/Dental School
- Ph.D - Indian Institute of Science, Molecular biology, 2000
- Postdoctoral - University of California, Cancer Biology, 2000-2004
- Biotechnology
- Cancer Biomarkers and Therapeutics
- Cell Biology
- Genomics/Metabolomics/Proteomics
- Hematology
- Immunology
- Molecular Biology
- Oncology
- Stem Cells and Regenerative Medicine
- Barwe, S. P., Kisielewski, A., Bonvini, E., Muth, J., Davidson-Moncada, J., Kolb, E. A., & Gopalakrishnapillai, A. (2022). Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia. Journal of Clinical Medicine, 11(5). doi:10.3390/jcm11051333
- Heikamp, E. B., Henrich, J. A., Perner, F., Wong, E. M., Hatton, C., Wen, Y., & Armstrong, S. A. (2022). The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood, 139(6), 894-906. doi:10.1182/blood.2021012806
View Full Publication - Barwe, S. P., Sebastian, A., Sidhu, I., Kolb, E. A., & Gopalakrishnapillai, A. (2022). Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21. Cells, 11(4). doi:10.3390/cells11040628
View Full Publication - Kaeding, A. J., Barwe, S. P., Gopalakrishnapillai, A., Ries, R. E., Alonzo, T. A., Gerbing, R. B., & Meshinchi, S. (2021). Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia. Blood Advances, 5(9), 2350-2361. doi:10.1182/BLOODADVANCES.2021004424
View Full Publication - Sidhu, I., Barwe, S. P., & Gopalakrishnapillai, A. (2021). The extracellular matrix: A key player in the pathogenesis of hematologic malignancies. Blood Reviews, 48. doi:10.1016/j.blre.2020.100787
View Full Publication - Sidhu, I., Barwe, S. P., Kiick, K. L., Kolb, E. A., & Gopalakrishnapillai, A. (2021). A 3-D hydrogel based system for hematopoietic differentiation and its use in modeling down syndrome associated transient myeloproliferative disorder. Biomaterials Science, 9(18), 6266-6281. doi:10.1039/d1bm00442e
View Full Publication - Sidhu, I., Barwe, S. P., Pillai, R. K., & Gopalakrishnapillai, A. (2021). Harnessing the power of induced pluripotent stem cells and gene editing technology: Therapeutic implications in hematological malignancies. Cells, 10(10). doi:10.3390/cells10102698
View Full Publication - Gopalakrishnapillai, A., Correnti, C. E., Pilat, K., Lin, I., Chan, M. K., Bandaranayake, A. D., & Barwe, S. P. (2021). Immunotherapeutic targeting of mesothelin positive pediatric aml using bispecific t cell engaging antibodies. Cancers, 13(23). doi:10.3390/cancers13235964
- Crowgey, E. L., Mahajan, N., Wong, W. H., Gopalakrishnapillai, A., Barwe, S. P., Kolb, E. A., & Druley, T. E. (2020). Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring. BMC Medical Genomics, 13(1). doi:10.1186/s12920-020-0671-8
View Full Publication - Quagliano, A., Gopalakrishnapillai, A., & Barwe, S. P. (2020). Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer. Frontiers in Oncology, 10. doi:10.3389/fonc.2020.00992
- Quagliano, A., Gopalakrishnapillai, A., Anders Kolb, E., & Barwe, S. P. (2020). CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia. Blood Advances, 4(18), 4393-4405. doi:10.1182/BLOODADVANCES.2020001592
View Full Publication - Barwe, S. P., Sidhu, I., Kolb, E. A., & Gopalakrishnapillai, A. (2020). Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology. Molecular Therapy - Methods and Clinical Development, 19, 201-209. doi:10.1016/j.omtm.2020.09.007
- Barwe, S. P., Quagliano, A., & Gopalakrishnapillai, A. (2017). Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. Seminars in Oncology, 44(2), 101-112. doi:10.1053/j.seminoncol.2017.06.005
View Full Publication - Quagliano, A., Gopalakrishnapillai, A., & Barwe, S. P. (2017). Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. Leukemia Research, 56, 36-43. doi:10.1016/j.leukres.2017.01.030
View Full Publication - Bloh, K. M., Bialk, P. A., Gopalakrishnapillai, A., Kolb, E. A., & Kmiec, E. B. (2017). CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Molecular Therapy - Nucleic Acids, 7, 288-298. doi:10.1016/j.omtn.2017.04.009
- Gopalakrishnapillai, A., Kolb, E. A., McCahan, S. M., & Barwe, S. P. (2017). Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia. Leukemia Research, 58, 91-97. doi:10.1016/j.leukres.2017.05.004
View Full Publication - Balasubramaniam, S. L., Gopalakrishnapillai, A., Petrelli, N. J., & Barwe, S. P. (2017). Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Journal of Biological Chemistry, 292(27), 11388-11399. doi:10.1074/jbc.M116.752352
View Full Publication - Gopalakrishnapillai, A., Kolb, E. A., Dhanan, P., Bojja, A. S., Mason, R. W., Corao, D., & Barwe, S. P. (2016). Generation of pediatric leukemia xenograft models in NSG-B2m mice: Comparison with NOD/SCID mice. Frontiers in Oncology, 6(JUN). doi:10.3389/fonc.2016.00162
- Gopalakrishnapillai, A., Kolb, E. A., Dhanan, P., Mason, R. W., Napper, A., & Barwe, S. P. (2015). Disruption of Annexin II /p11 interaction suppresses leukemia cell binding, homing and engraftment, and sensitizes the leukemia cells to chemotherapy. PLoS ONE, 10(10). doi:10.1371/journal.pone.0140564
View Full Publication - Balasubramaniam, S. L., Gopalakrishnapillai, A., Gangadharan, V., Duncan, R. L., & Barwe, S. P. (2015). Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling. Journal of Biological Chemistry, 290(20), 12463-12473. doi:10.1074/jbc.M114.629519
View Full Publication - Balasubramaniam, S. L., Gopalakrishnapillai, A., & Barwe, S. P. (2015). Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration. American Journal of Physiology - Cell Physiology, 309(6), C437-C441. doi:10.1152/ajpcell.00140.2015
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