Sigrid A Langhans, PhD

Head - Cancer Epigenetics Research Laboratory

Langhans, S. A. (2021). Using 3D in vitro cell culture models in anti-cancer drug discovery. Expert Opinion on Drug Discovery, 16(8), 841-850. doi:10.1080/17460441.2021.1912731
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Li, Z., & Langhans, S. A. (2021). In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview. Frontiers in Oncology, 11. doi:10.3389/fonc.2021.620831
Nikam, R. M., Yue, X., Kandula, V. V., Paudyal, B., Langhans, S. A., Averill, L. W., & Choudhary, A. K. (2021). Unravelling neuroinflammation in abusive head trauma with radiotracer imaging. Pediatric Radiology, 51(6), 966-970. doi:10.1007/s00247-021-04995-z
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Yue, X., Nikam, R. M., Kecskemethy, H. H., Kandula, V. V. R., Falchek, S. J., Averill, L. W., & Langhans, S. A. (2021). Radiosynthesis of 1-(2-[18f]fluoroethyl)-l-tryptophan using a one-pot, two-step protocol. Journal of Visualized Experiments, 2021(175). doi:10.3791/63025
Xin, Y., Yue, X., Li, H., Li, Z., Cai, H., Choudhary, A. K., & Langhans, S. A. (2020). PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model. Scientific Reports, 10(1). doi:10.1038/s41598-020-60728-6
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Litan, A., Li, Z., Tokhtaeva, E., Kelly, P., Vagin, O., & Langhans, S. A. (2019). A Functional Interaction Between Na,K-ATPase B2-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells. Molecular Neurobiology, 56(11), 7557-7571. doi:10.1007/s12035-019-1592-4
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Worthington, P., Drake, K. M., Li, Z., Napper, A. D., Pochan, D. J., & Langhans, S. A. (2019). Implementation of a High-Throughput Pilot Screen in Peptide Hydrogel-Based Three-Dimensional Cell Cultures. SLAS Discovery, 24(7), 714-723. doi:10.1177/2472555219844570
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Wolf, D. M. C., & Langhans, S. A. (2019). Moving myeloid leukemia drug discovery into the third dimension. Frontiers in Pediatrics, 7(JULY). doi:10.3389/fped.2019.00314
Langhans, S. A. (2018). Three-dimensional in vitro cell culture models in drug discovery and drug repositioning. Frontiers in Pharmacology, 9(JAN). doi:10.3389/fphar.2018.00006
Worthington, P., Langhans, S., & Pochan, D. (2017). B-hairpin peptide hydrogels for package delivery. Advanced Drug Delivery Reviews, 110-111, 127-136. doi:10.1016/j.addr.2017.02.002
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Worthington, P., Drake, K. M., Li, Z., Napper, A. D., Pochan, D. J., & Langhans, S. A. (2017). Beta-hairpin hydrogels as scaffolds for high-throughput drug discovery in three-dimensional cell culture. Analytical Biochemistry, 535, 25-34. doi:10.1016/j.ab.2017.07.024
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Sun, J. E. P., Stewart, B., Litan, A., Lee, S. J., Schneider, J. P., Langhans, S. A., & Pochan, D. J. (2016). Sustained release of active chemotherapeutics from injectable-solid B-hairpin peptide hydrogel. Biomaterials Science, 4(5), 839-848. doi:10.1039/c5bm00538h
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Li, Z., & Langhans, S. A. (2015). Transcriptional regulators of Na,K-ATPase subunits. Frontiers in Cell and Developmental Biology, 3(OCT). doi:10.3389/fcell.2015.00066
Lee, S. J., Li, Z., Litan, A., Yoo, S., & Langhans, S. A. (2015). EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation. BMC Cell Biology, 16(1). doi:10.1186/s12860-015-0070-8
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Lindsey, S., Piatt, J. H., Worthington, P., Sonmez, C., Satheye, S., Schneider, J. P., & Langhans, S. A. (2015). Beta hairpin peptide hydrogels as an injectable solid vehicle for neurotrophic growth factor delivery. Biomacromolecules, 16(9), 2672-2683. doi:10.1021/acs.biomac.5b00541
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Lee, S. J., Litan, A., Li, Z., Graves, B., Lindsey, S., Barwe, S. P., & Langhans, S. A. (2015). Na,K-ATPase B1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Molecular Cancer, 14(1). doi:10.1186/s12943-015-0430-1
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Litan, A., & Langhans, S. A. (2015). Cancer as a channelopathy: Ion channels and pumps in tumor development and progression. Frontiers in Cellular Neuroscience, 9. doi:10.3389/fncel.2015.00086
Worthington, P., Pochan, D. J., & Langhans, S. A. (2015). Peptide hydrogels - versatile matrices for 3D cell culture in cancer medicine. Frontiers in Oncology, 5(APR). doi:10.3389/fonc.2015.00092
Lindsey, S., & Langhans, S. A. (2015). Epidermal growth factor signaling in transformed cells. In International Review of Cell and Molecular Biology (Vol 314, bll 1-41). doi:10.1016/bs.ircmb.2014.10.001
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Sigrid A Langhans, PhD

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Sigrid A Langhans, PhD

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