Your child’s endocrine system contains hormone-producing glands that help maintain growth and development, puberty, energy level and mood. Endocrine disorders in children are caused by too many or too few hormones circulating throughout the body. In order for your child’s body to function, everything needs to be working in harmony — that is, the glands need to secrete just the right amount of hormones throughout the blood stream.
Glands in the Endocrine System
The main glands of the endocrine system include:
Other glands that contain endocrine tissue and secrete hormones include:
The endocrine system and the nervous system work closely together. The brain sends messages and receives feedback through a “switchboard” called the hypothalamus (the part of the brain that controls the endocrine system). When this system isn’t working properly, hormone and growth problems can occur.
Lately, it seems as though your child is looking up to classmates — literally. The other kids in the class have been getting taller and developing into young adults, but your child's growth seems to be lagging behind. Classmates now tower over your child.
Is something wrong? Maybe, maybe not. Some kids just grow more slowly than others because their parents did, too. But others may have an actual growth disorder, which is any type of problem that prevents kids from meeting realistic expectations of growth, from failure to gain height and weight in young children to short stature or delayed sexual development in teens.
Variations of Normal Growth Patterns
A couple of differences seen in the growth patterns of normal children include these common conditions, which are not growth disorders:
Constitutional growth delay: This condition describes children who are small for their ages but who are growing at a normal rate. They usually have a delayed "bone age," which means that their skeletal maturation is younger than their age in years. (Bone age is measured by taking an X-ray of the hand and wrist and comparing it with standard X-ray findings seen in kids the same age.)
These children don't have any signs or symptoms of diseases that affect growth. They tend to reach puberty later than their peers do, with delay in the onset of sexual development and the pubertal growth spurt. But because they continue to grow until an older age, they tend to catch up to their peers when they reach adult height. One or both parents or other close relatives often had a similar "late-bloomer" growth pattern.
Familial (or genetic) short stature: This is a condition in which shorter parents tend to have shorter children. This term applies to short children who don't have any symptoms of diseases that affect their growth. Kids with familial short stature still have growth spurts and enter puberty at normal ages, but they usually will only reach a height similar to that of their parents.
With both constitutional growth delay and familial short stature, kids and families need to be reassured that the child does not have a disease or medical condition that poses a threat to health or that requires treatment.
However, because they may be short or may not enter puberty when their classmates do, some may need extra help coping with teasing or reassurance that they will go through full sexual development eventually. In a few children who are very short or very late entering puberty, hormone treatment may be helpful.
Diseases of the kidneys, heart, gastrointestinal tract, lungs, bones, or other body systems might affect growth. Other symptoms or physical signs in kids with these illnesses usually give clues as to the disease causing the growth delay. However, poor growth can be the first sign of a problem in some.
Growth disorders include:
Failure to thrive, which isn't a specific growth disorder itself, but can be a sign of an underlying condition causing growth problems. Although it's common for newborns to lose a little weight in the first few days, failure to thrive is a condition in which some infants continue to show slower-than-expected weight gain and growth. Usually caused by inadequate nutrition or a feeding problem, it's most common in kids younger than age 3. It may also be a symptom of another problem, such as an infection, a digestive problem, or child neglect or abuse.
Endocrinediseases (diseases involving hormones, the chemical messengers of the body) involve a deficiency or excess of hormones and can be responsible for growth failure during childhood and adolescence. Growth hormone deficiency is a disorder that involves the pituitary gland (the small gland at the base of the brain that secretes several hormones, including growth hormone). A damaged or malfunctioning pituitary gland may not produce enough hormones for normal growth. Hypothyroidism is a condition in which the thyroid gland fails to make enough thyroid hormone, which is essential for normal bone growth.
Turner syndrome, one of the most common genetic growth disorders, occurs in girls and is a syndrome in which there's a missing or abnormal X chromosome. In addition to short stature, girls with Turner syndrome usually don't undergo normal sexual development because their ovaries (the sex organs that produce eggs and female hormones) fail to mature and function normally.
Diagnosing a Growth Disorder
The tests a doctor may recommend to detect a growth disorder depend on the findings at each step of evaluation. A short child who's healthy and growing at a normal rate may just be observed throughout childhood, but one who has stopped growing or is growing more slowly than expected will often need additional testing.
Your doctor or an endocrinologist will look for signs of the many possible causes of short stature and growth failure. Blood tests may be done to look for hormone and chromosome abnormalities and to rule out other diseases associated with growth failure. A bone age X-ray might be done and special scans (such as an MRI) can check the pituitary gland for abnormalities.
To measure the ability of the pituitary gland to produce growth hormone, the doctor (usually a pediatric endocrinologist) may do a growth hormone stimulation test. This involves giving the child medications that cause the pituitary gland to secrete growth hormone, then drawing several small blood samples over time to check growth hormone levels.
Treating a Growth Disorder
Although the treatment of a growth problem usually isn't urgent, earlier diagnosis and treatment can help some kids catch up with peers and increase their final height.
If an underlying medical condition is identified, specific treatment may result in improved growth. Growth failure due to hypothyroidism, for example, is usually treated with thyroid hormone replacement pills.
Growth hormone injections for children with growth hormone deficiency, Turner syndrome, and chronic kidney failure may help kids reach a more normal height. Human growth hormone is generally considered safe and effective, although full treatment may take many years and not all kids will have a good response. And the treatment can be costly (about $20,000 to $30,000 per year), although many health insurance plans cover it.
What about growth hormone treatment for short children who aren't growth hormone deficient when tested? The U.S. Food and Drug Administration (FDA) has approved its use in such children if they're predicted to reach a very short final height (under 4 feet 11 inches [150 centimeters] for a girl; under 5 feet 4 inches [163 centimeters] for a boy).
Talk with your doctor for more information about treatment options if you're concerned.
Helping Your Child
You can boost your child's self-esteem by providing positive reinforcement and emphasizing other characteristics, like intelligence, personality, and talents. Try to take the focus off of height as a measure of social acceptance.
Kids who are very self-conscious about their size might need help in coping. In some cases, evaluation and treatment by a mental health professional may be needed.
If You Suspect a Problem
If you're concerned about your child's growth, speak with your doctor, who may refer you to a pediatric endocrinologist, who can help diagnose and treat specific growth disorders.
It's also important to watch for the social and emotional problems that kids with growth disorders face. It's not easy being the shortest kid in the class and it's never any fun being teased. Helping your child build self-esteem and emphasizing strengths — regardless of how tall he or she may grow — might be just what the doctor ordered.
Reviewed by: Steven Dowshen, MD
Date reviewed: April 28, 2017