Kidney Transplant

mother and child laying on the grass

If your child has end-stage renal disease (when kidney damage is severe and the kidneys are failing) our caring, highly skilled, and experienced Solid Organ Transplant team can offer the hope of a kidney transplant. With more than two decades of experience and numerous successful transplants our team oversees one of the largest pediatric transplant programs in the country.

Read More About Kidney Transplant

The kidneys act as the body’s filtering system. They help control water levels and eliminate wastes through urine, as well as regulate blood pressure, red blood cell production, and the levels of calcium and minerals. Kidney failure (also called “renal failure”) is when the kidneys slow down or stop filtering blood effectively, causing waste products and toxic substances to build up in the blood.

Kidney failure can be:
  • acute (which means sudden and sometimes temporary): may be due to bacterial infection, injury, shock, heart failure, or
    drug overdose
  • chronic (occurring over time and usually long-lasting or permanent): In kids and teens, it can result from acute kidney failure that fails to improve, birth defects, chronic kidney diseases, or chronic severe high blood pressure. If diagnosed early, chronic kidney failure can be treated. But the child will usually require a kidney transplant at some point in the future.
Kidney Diseases Leading to Dialysis and Transplantation

A large ongoing study called the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) is designed to monitor long-term trends in the development of kidney disease and changes in the management of patients with end-stage kidney disease. According to the most recent statistics from this large database, the majority of children end up in renal failure and in need of a kidney transplant from the following causes:

  • Underdevelopment of the kidneys (renal dysplasia and hypoplasia): when (for unknown reasons) a baby is born with less kidney tissue or the existing kidney tissue doesn’t function normally
  • Glomerulonephritis (an inflammatory process within the kidneys): which affects the glomeruli (small structures in the kidneys that supply blood flow to the filtering part of the kidneys)
  • Focal segmental glomerulosclerosis: when scar tissue forms in the glomeruli and protein leaks into the urine; some cases don’t improve with medication and require transplantation
  • Obstruction (blockage) of the urinary collecting system: when the blockage of the urine flow damages the kidneys and can occur while the fetus is still in the mother’s womb
Types of Kidney Donors

Your child may be able to get a donated kidney in one of two ways,
from a:

  • living donor: either a relative (this is called a “living related donor”) or another unrelated person who the care team determines is a
    good match.
  • deceased (or cadaver) donor: the most common way, donated by a healthy adult or child who became critically ill and died of an illness (after the person or his or her guardians agreed to donate the organs in the event of a sudden death). 

Our kidney transplant team performs living-related donor procedures whenever possible. Of course, not every child can get a living donor, but this technique does make it possible for more children to receive a kidney transplant as soon as possible and increases their chances of long-term survival after the transplant. If there’s no willing and compatible living donor your child will be waiting until a kidney becomes available from the local and national organ donor waiting lists.

How a Kidney Transplant Works

Once your child gets the team’s OK after all of the required tests and consultations (see Solid Organ Transplant for more information) and a deceased or living donor match is found, your child is ready for the transplant surgery. Your child will only need one donor kidney, which can take over the function of both failing kidneys.

For the transplant, your child’s original kidneys are usually left in place, except in rare cases where they’re removed because they’re too large from disease or they’re wasting protein.

The transplanted kidney may either start to work immediately or it may take a few days to get up to speed.

Patients who’ve had kidney transplants will need to be admitted directly to our Pediatric Intensive Care Unit from the operating room. Here, they’ll be monitored carefully during the first few days after surgery. Children can usually eat again in a few days and begin to resume some normal activity soon after.

Nemours/Alfred I. duPont Hospital for Children, Wilmington

1600 Rockland Road
Wilmington, DE 19803
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For Appointments: (302) 651-4200

Seeing Multiple Specialists?

Our Patient Navigators can help schedule multiple appointments on the same day at the same location.

(800) 451-2854

What to Bring
  • photo ID
  • medical and pharmacy insurance cards
  • preferred pharmacy name and phone number
  • names and dosage of all medications, including over-the-counter medication, your child is currently taking
  • guardianship and custody papers, if a legal guardian rather than a parent accompanies your child
Returning Patients
  • Patient Presents Without Legal Guardian (PDF)
    English | Spanish
    Note: A parent or legal guardian must be with a child for a first visit.
Forms & Resources
Returning Patients
  • Patient Presents Without Legal Guardian (PDF)
    English | Spanish
    Note: A parent or legal guardian must be with a child for a first visit.
Resources for Patients & Families

U.S. News & World Report Best Children’s Hospitals: Nephrology

If your child needs a kidney transplant, Nemours/Alfred I. duPont Hospital for Children offers a wide variety of comprehensive services from our expert Solid Organ Transplant team.

Why Choose Nemours

  • We focus on your child’s quality of life during and after transplant
  • We offer top-rate therapy that helps kids recuperate and get back home quicker. Our length of stay is shorter than national averages; many of our transplant patients are back home in three or four weeks after transplant
  • Our multidisciplinary team of specialists will consider the needs of every child referred to us, no matter how complicated the case
  • We provide excellent, personalized care that places the patient and family at the center
  • We work as one coordinated team

Our Experts

Our transplant team is made up of a family of highly experienced, qualified, caring health professionals who dedicate their lives to helping children just like yours.

  • transplant coordinator, a specially trained nurse who serves as your point person from start to finish, arranging all of the details of your child’s care
  • transplant surgeons, who are trained and board-certified in pediatric surgery and have further training in pediatric liver transplantation
  • nurses, who oversee your child’s care around the clock, taking care of your child’s needs day and night
  • pediatricians, who offer insight into the long-term care of the transplant patient as well as immediate care around the time of transplantation
  • financial coordinator, who works with you and your insurance company to coordinate all financial aspects of your child’s care before and well after transplantation
  • social worker, who is involved with your family from the pre-transplant evaluation through transplantation and post-transplant care, providing emotional support and helping you prepare for each step of the process
  • physical and occupational therapists, who encourage specific activities as well as movement to make sure your child is physically strong before leaving the hospital
  • Child Life specialists, who are specially trained to work with kids who are sick or disabled and are receiving treatment in a hospital setting
  • psychologists and psychiatrists, who offer a wide range of support services to children and families before and long after the transplant
  • clergy, who can offer spiritual and emotional support
  • dietitians/nutritionists, who offer advice and meal plans for kids with specific nutritional needs
  • other support staff, such as pharmacists and laboratory technicians

Post-Transplant Care

After children get a kidney transplant they still need to take medications (called immunosuppressants or anti-rejection medications) for the rest of their lives to maintain their best possible health and ensure that their bodies don’t reject the new organ. When it’s time to take your child home after the transplant we’ll go over everything you need to know about after-care — homecare, school, financial and insurance issues, transportation, medications, as well as signs and symptoms of infection and organ rejection.

And we follow all of our patients very closely post-transplant, both as inpatients in the hospital and as outpatients. You can rest assured that we’ll give your child customized aftercare and support to ensure the best possible chance for a healthier future.

Also be sure to talk to your transplant coordinator about whether and where you can see your child’s doctors at other Nemours outpatient clinics and offices for post-transplant follow-up care.