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Neurodevelopmental/Musculoskeletal Research

Nemours researchers in the Delaware Valley and Florida are leading the effort to develop life-changing technologies that help children with musculoskeletal diseases — like skeletal dysplasia, scoliosis, cerebral palsy and others — experience the world more independently. At the same time, we’re gaining new insights into the causes of many neurodevelopmental disorders and new ways to treat them.

Our Center for Orthopedics Research and Development (CORD) is a leading international pediatric biomedical research center in Orthopedics. And the labs within our Center for Pediatric Auditory and Speech Sciences (CPASS) focus their work on clinical applications that bear immediate relevance for children with congenital and acquired neurological, neuromuscular, and anatomical disorders.

Active Research

With a mission to provide groundbreaking research and exceptional clinical care, we are focused on improving the lives of children with neurodevelopmental and musculoskeletal disorders. Some of our significant research projects are highlighted here.

 
Force-Driven Instrumentation for Leg Lengthening

Sometimes children develop with one leg or one arm shorter than the other. To correct this problem, orthopedic surgeons can perform a procedure called distraction osteogenesis to lengthen the bone in the shorter limb of a child whose bones are still developing. Typically, surgeons perform an osteotomy (remove part of the bone) and then distract (separate) the divided bone segments gradually so that new bone tissue forms to bridge the gap.

The rate of lengthening is usually held constant (about 1 millimeter per day) and does not consider variations in patients. But because children grow at their own pace, the constant force of the lengthening might be too great or too little at a given time, causing pain and possible damage to tissues as they grow. Research scientists and pediatric orthopedic surgeons at Nemours Pediatric Engineering Research Lab, part of the Center for Orthopedics Research and Development, are changing that.

We’re working on a method to measure the forces in the distraction zone (the area where limb lengthening occurs) using a sensor and vary the distraction rate (the amount of force that separates the bone) automatically. We hope this ability to adjust the lengthening forces will produce better results, with fewer problems and less discomfort for the child.


Investigators
  • William G. Mackenzie, MD
  • Tariq Rahman, PhD
  • Jinyong Wee, PhD
  • Rahamim Seliktar, PhD, Drexel University
  • Robert E. Akins, PhD
  • Dean Richardson, DVM, University of Pennsylvania
  • David Levine, DVM, University of Pennsylvania
 
Wilmington Robotic EXoskeleton (WREX)

Children with neuromuscular disease often have difficulty moving their arms and performing activities of daily living due to muscle weakness. Wilmington Robotic EXoskeleton (WREX) is an arm orthosis that helps children with very little residual strength to move their arms in space. It is primarily intended for people with muscular dystrophy, spinal muscular atrophy, and arthrogryposis in which the distal muscles (those farther away from the joint) are less affected and sensation remains intact.

WREX is a two-segment device that uses elastic bands to help a child move the arm in 3-D space. It allows full passive range of motion of the arm and provides a sense of flotation that assists in voluntary movement. It can easily be adjusted to accommodate a child’s size, weight, and arm length. WREX is typically mounted to a wheelchair. When attached to a body jacket, it can also help children with arthrogryposis walk independently. WREX was conceived and developed at Nemours/Alfred I. duPont Hospital for Children and is being sold by JAECO Orthopedics. It can also be found in the Patterson Medical catalogue.

WREX II, the next generation currently under development, has easily adjustable link lengths and anti-gravity lift. It can also be switched from the right to the left hand and is enclosed in a plastic cover. WREX II is motorized so a user can lift heavier objects and overcome profound weakness. The motors assist the rubber bands in creating just the right tension to lift the arm.


Emma's Magic Arms

2-year-old Emma wanted to play with blocks, but a condition called arthrogryposis meant she couldn't move her arms. Researchers at Nemours 3-D-printed a durable custom exoskeleton with the tiny, lightweight parts she needed.


Investigators
  • Tariq Rahman, PhD
  • William G. Mackenzie, MD
  • Whitney Sample, BFA
  • Shanmuga S. Jayakumar, MD
  • Daniel Ragonesi, BSME
  • Joe Basante OTR/L MA
  • Michael Alexander MD
 
The Cricket, a Brace Compliance Sensor

For most children with idiopathic scoliosis, spinal bracing has been the mainstay of conservative treatment to halt the progression of moderate idiopathic curves. But for the brace to work properly, the child has to closely follow a prescribed brace-wearing schedule.

Most studies on the effectiveness of these spinal orthoses (braces) have relied on medical records and after-the-fact phone interviews to determine each child’s average daily brace-wear time. Because this information is subjective, Nemours researchers looked for a way to measure brace-wear compliance more accurately, without delays and subjectivity.

They developed a compliance sensor that records brace-wear time objectively. From this early design, they designed an improved compliance sensor called the Cricket. The sensor is sealed, self-contained, and can be obtained with a small screen that provides information on average hours the brace is worn. The Cricket was manufactured in partnership with Creative MicroDesigns and is being sold commercially by Boston Brace.


Investigators
 
Therapies for Managing Duchenne Muscular Dystrophy

What medications work best to slow the progression of symptoms for children with Duchenne muscular dystrophy? Research scientists at Nemours Children’s Hospital in Orlando, are preparing to participate in a number of studies that compare results obtained with different approaches. The research team will be investigating which steroids and other medications are most effective in managing symptoms of Duchenne muscular dystrophy among children of different ages.

 
Auditory Processing Disorders (APD) in Children

It’s one thing to hear normally in a quiet environment. But in a noisy room, some people with auditory processing disorders (APDs) have trouble focusing on one sound and ignoring the background sounds. APD can be a problem for some children, who might struggle academically because they have difficulty understanding what teachers and classmates are saying.

Researchers at the Auditory Physiology and Psychoacoustics Laboratory (APPL) are working with audiologists and other specialists at Nemours/Alfred I. duPont Hospital for Children to investigate the neurological pathways that translate sounds into information. They hope to uncover some of the causes of APD – and ways to train the brain to recognize speech in noisy environments. Considering that one in 20 school-age children has some form of APD, the implications of this research could be huge.

 
Auditory Neuropathy Spectrum Disorder (ANSD) in Children

Researchers at the Auditory Physiology and Psychoacoustics Laboratory (APPL) are starting to gain insights into a range of neurodevelopmental issues called Auditory Neuropathy Spectrum Disorders (ANSD). Children with ANSD experience a form of hearing loss caused when the nerves connecting the inner ear to the brain become damaged or when the cells connected to the auditory nerve are not functioning.

Working with otolaryngologists (ENT specialists), audiologists, speech pathologists, neurologists, geneticists and medical imaging technicians, our investigators are looking closely at physical causes of this multi-faceted timing disorder. We’ve discovered a number of conditions that might contribute to a child’s risk of developing ANSD, and we’re investigating individualized ways of managing the disorder.

Our Centers

At Nemours, much of the research into neurodevelopmental and pediatric musculoskeletal disorders is centered in two highly respected centers:

 
Center for Applied Clinical Genomics (CACG)

Our Center’s clinical and translational research programs are dedicated to understanding how genetic mutation and variation affect children’s health. Our investigators collaborate with clinical and research faculty within and across Nemours campuses.

Research faculty members also take part in a wide network of external collaborations that have led to the recognition of Nemours as a leader in pediatric research. The CACG will be working to leverage regional resources in genomic sequencing and bioinformatics to develop state-of-the art approaches to the discovery of the molecular basis of genetic disorders, placing Nemours at the forefront of Genomic Medicine.


Learn More About Our Applied Genomics Research »

 
Center for Orthopedic Research and Development (CORD)

The Center for Orthopedics Research and Development (CORD) works closely with Nemours Department of Orthopedics to develop devices and methods that directly impact children with musculoskeletal and orthopedic disabilities. Our research efforts are focused within the Pediatric Engineering Research Laboratory (PERL).

CORD strives to produce tangible benefits for children by partnering with companies and obtaining extramural and intramural grants. Several patents from the PERL have been granted, including the WREX (Wilmington Robotic EXoskeleton) that allows children with weakness to move their arms in three-dimensional space in front of them, and the Cricket, a brace compliance sensor.

The Center also collaborates with regional academic institutions including Drexel University, the University of Delaware and the University of Pennsylvania.

CORD works closely with the Gait Analysis Laboratory at the duPont Hospital for Children, created in 1993 to provide advanced, computer-assisted motion analysis of the complex gait cycle. In addition to the lab’s work with individual pediatric patients, it’s also responsible for a number of research studies that add to our understanding of gait motion and ways to analyze it.

 
Center for Pediatric Auditory and Speech Sciences (CPASS)

The Center for Pediatric Auditory and Speech Sciences (CPASS) is dedicated to translational research in the audiological and speech sciences with the goal of advancing the practice of pediatric health care in related areas, while simultaneously advancing the underlying science.

The Center seeks to tightly integrate research laboratories and clinical health care programs to maximize the potential benefits of data collection for all Nemours professionals and the patients and families we serve. The labs that comprise CPASS frequently collaborate with Nemours pediatric specialists in the Divisions of Otolaryngology (ENT), Neurosurgery, Orthopedics, Ophthalmology and Genetics, among others. Throughout Delaware and in Florida, CPASS also reaches out to local communities providing outreach and educational services such as infant auditory screening, and consultation and support services for local education institutions.

There are a variety of congenital and acquired neurological, neuromuscular and anatomical disorders that can cause a child’s inability to speak, hear or maintain balance such as cerebral palsy, autism, apraxia of speech (motor speech disorder), traumatic brain injury and spinal cord injury, to name a few. The CPASS research efforts are aimed toward clinical applications that bear immediate relevance to these patients.

Participating labs in CPASS include:
  • Speech Research Laboratory (SRL) focuses on speech genetics, computer-based solutions for children with speech and language disorders and for the clinicians who care for them, and the study of computerized speech processing and training. Our current efforts are directed principally towards speech genetics.
  • Craniofacial Outcomes Research Laboratory (CORL) studies speech and resonance disorders related to cleft palate and craniofacial anomalies. We work with a variety of technologies to measure vocal track pressure and airflow, including: PERCI-SARS (a software-based instrumentation system); InvTool (a program used to record speech for synthesizing); and Nasometry (a non-invasive technique used to measure the size of the velopharyngeal opening combined with the measurement of nasal emission).
  • Balance and Vestibular Disorders Laboratory (BVD) works with the Gait Analysis, Auditory Physiology and Psychoacoustics, and other labs to analyze and research a variety of issues related to pediatric balance and vestibular disorders. These include otitis media, Chiari type 1 malformations, pediatric migraine, recurrent vertigo, and others.
  • Auditory Physiology and Psychoacoustics Research Laboratory (APPL) works on a variety of projects related to hearing and balance disorders in children. Current areas of study include children with:
    • Chiari type I malformation (a structural defect in the part of the brain that controls balance)
    • otitis media with effusion (fluid in the middle ear space without symptoms of an acute ear infection)
    • imbalance disorders

The lab also runs a clinical program targeting the diagnosis and management of auditory neuropathy spectrum disorder (ANSD) in infants and children, and maintains a database to help identify risk factors that can be helpful for early intervention.

Publications & Clinical Trials

Publications

Browse a listing of research publications from Nemours researchers related to neurodevelopmental and musculoskeletal conditions in children.

View Publications »


Current Clinical Trials:

View All Neurodevelopmental/Musculoskeletal Clinical Trials »


Is a Clinical Trial Right For Your Child? »

Turning Research Into Breakthroughs

See how our neuromuscular innovations help patients like Matthew. Read His Story »

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