U.S. News & World Report 2011-12 edition of “Best Children’s Hospitals” ranks pediatric cardiac care at Nemours/Alfred I. duPont Hospital for Children among the best in the country.
Nemours Pediatric Cardiology Ranks Among the Best

Patient Story

Cardiology: Capucine
When Capucine was born she seemed perfect, except for a slight heart murmur. When the murmur was still present several days later, Capucine’s pediatrician told parents Jennifer and Christophe that, out of an abundance of caution, she should be evalua...
Even Better Days To Come
See how we help children reach their full potential in this engaging spot about the Cardiac Center at Nemours/Alfred I. duPont Hospital for Children.
Cardiac Center

The Nemours Cardiac Center, located in the world-renowned Nemours/Alfred I. duPont Hospital for Children (AIDHC), is dedicated and specially designed to deliver the best possible care to infants and children with heart disease. We’re convinced that virtually all forms of childhood heart disease, even the most unusual and complicated, can be treated. And we know that early diagnosis and treatment give your child the very best chance of leading a happy, active, and long life.
We believe that people do best what they do everyday. At the Nemours Cardiac Center, an entire team of medical experts (in pediatric cardiac surgery, cardiology, anesthesiology, and critical care) is dedicated solely to the special challenges of childhood heart abnormalities. Having made the care of children with heart disease their life’s work, our team members come from other excellent institutions to the Nemours Cardiac Center to provide the best care possible for any child with heart problems, from mild to complex.
Families from all over the region, the country, and the world put their children’s hearts in our hands. We treat young patients from not only Delaware, New Jersey, Maryland, and Pennsylvania, but from throughout the United States – and the globe. Here are some of the many reasons why you can feel confident in putting your child’s heart in our hands:
Top-of-the-line treatment
Every square inch of our Center is used only for the care of infants and children with heart disease. Our Cardiac Center features a 10-bed cardiac intensive care unit; a 16-bed “step-down unit” (used for children who require less observation); an operating room; and a new, digital, state-of-the-art cardiac catheterization and electrophysiology suite (where kids can be diagnosed and treated for many common heart conditions).
We offer first-class heart surgery as well as modern, non-surgical approaches to treating many children’s heart conditions. We’ve also become a leader in minimizing the number of operations our young patients need. The techniques and advances we use can help babies and children avoid the trauma and recovery time of open-heart surgery. Our treatment options improve the outlook for scores of children – with less discomfort and shorter hospital stays. And we’re one of only a mere handful of centers in the United States where certain treatment capabilities are available.
Advanced care from our comprehensive team
The Cardiac Center is about far more than our impressive facility and high-tech equipment. Our highly specialized, caring staff includes professionals trained in – and dedicated completely to – cardiac care for children, including:
- pediatric cardiologists (kids’ heart doctors) – including interventional cardiologists (doctors who repair heart problems without surgery) and electrophysiology cardiologists (doctors who evaluate and treat abnormal heart rhythms)
- pediatric cardiac surgeons
- pediatric cardiac anesthesiologists
- a team of nurses, technicians, and social workers
We make it easier for you to see everyone on your child’s care team at the same time, rather than sending you from place to place. Families can usually see cardiologists and other specialists on a single day, all at one location. And we all work together every day to provide the most up-to-date care available to children with cardiac problems.
Our cardiac teams also use something called “telemedicine” to immediately view charts, X-rays, scans, and other patient information via two-way video equipment using fiber-optic telephone lines. So our young patients benefit from the knowledge of experts across the country who analyze visual data and do consultations, in real time. And that means it takes less time to make important diagnostic and surgical decisions. Telemedicine allows us to consult with some of the best minds in the world in cardiac care for our patients, taking the “second opinion” to a whole new level.
Big help for the littlest hearts
Since about two-thirds of patients with critical heart disease present as babies, we know that it’s often the tiniest hearts that need the most help – and as soon as possible. But thanks to advanced technology and our expert team of specialists, most children born with a heart defect or condition – even newborns only hours old – can be quickly diagnosed and treated right when it matters the most.
If your unborn baby has a heart defect, close coordination among specialists is critically important. The Nemours Cardiac Center’s fetal cardiology team works with your obstetrician and/or perinatologist (a doctor who specializes in high-risk pregnancies) to help plan for the evaluation and treatment of your baby’s heart condition before and after birth. Early in-utero diagnosis (when your baby is still in the womb) offers you invaluable time to prepare emotionally and to make sound medical and financial arrangements for your child’s care. The Cardiac Center staff is here to help educate and guide you through the process of understanding the defect, what will happen after delivery, and what surgical or non-surgical procedure will be required to remedy the problem.
Specializing in early diagnosis and repair
Whatever kind of heart problem your child has, we specialize in early detection and repair, so that your child will have the very best possible chance for a healthy future. Early detection and treatment of a child's heart defect can often prevent damage and allow the heart to begin to function normally as quickly as possible.
We use a wide range of advanced diagnostic tests to get to the bottom of kids’ heart problems. Depending on your child’s age and condition, tests may include:
- electrocardiograms (or EKGs)
- imaging tests (such as echocardiograms, MRIs, and CT scans)
- exercise tests (to assess how your child’s lungs and heart hold up during physical activity)
National accreditation for our Echocardiography Department
Echocardiography (or “echo,” for short) is a specialized form of ultrasound that builds a picture of the heart using sound waves. The Echocardiography Department within the Nemours Cardiac Center received a three-year accreditation for pediatric transthoracic echocardiography by the Intersocietal Commission for the Accreditation of Echocardiography Laboratories (ICAEL). Accreditation by ICAEL signifies the country’s highest level of achievement in the specialty.
Support for you – the parent – from the get-go
We don’t just care for your child at the Nemours Cardiac Center, we make sure that you are also able to deal with the many new issues and sometimes seemingly overwhelming emotions and responsibilities parents of children with heart disease often face. We’re dedicated to providing you with one-on-one emotional support and access to programs and support groups to help you cope.
We take care of the little details, too, to ease your stress as much as possible. If you need a medically assisted transport, our staff will arrange for air or ground ambulance service – allowing you to concentrate on your child, not on how you’re going to get here. Our staff will also work with your health plan to make sure that an agreement can be made about payment. We accept most major health plans as well as Delaware and out-of-state Medicaid. And qualifying patients can apply for financial support through the Nemours Foundation.
Our colorful, family-oriented environment
Every phase of treatment and hospitalization is intended to keep you with your child – and to take some of the anxiety and fear out of evaluation, treatment, and rehabilitation. Our vibrant, kid-friendly rooms are designed to feel like your home-away-from-home with a private bathroom, bulletin board to display cards or artwork, telephone, color TV, and DVD. At least one parent is usually welcome to stay with their child overnight in a provided cot. If your child requires more critical care, our Cardiac Intensive Care Unit rooms have full beds so you can be available, day and night, when your child needs you the most.
More information on inpatient stays is available in our Patient and Family section.
The Tissue Engineering & Regenerative Medicine (TERM) Lab investigates pediatric disorders affecting muscle. The overall goal is to improve health outcomes for children with acquired and congenital diseases associated with muscle malformation or malfunction, including cardiac and vascular muscle insufficiency in patients with congenital cardiovascular disease (CCD).
The Nemours Cardiac Center performs more than 200 surgeries each year to treat CCD in children. Although these surgical treatments have become quite advanced, there are four critical areas for improvement:
- Develop alternatives to organ transplantation and non-adaptive synthetic grafts. There is a significant need for advanced cardiovascular implants for use in children. Along with members of the Nemours Cardiac Center and colleagues from the University of Delaware, the TERM lab applies advanced concepts in cellular physiology and materials science engineering to translational research aimed at developing biosynthetic implants and regenerative therapies for children with cardiovascular disease. Two studies are currently underway:
- Biomaterials for cardiovascular tissue engineering
- Molecular design of advanced biomaterials
- Improve tissue survival and function. It is critical to sustain tissue function after invasive procedures, which may cause damage directly or indirectly. Collaborations between team members of Nemours Cardiac Center and colleagues at the University of Delaware continue to evaluate the roles of specific protein pathways in attenuating tissue damage.
- Improve diagnostics for post-surgical outcomes. The TERM lab has established a post-surgical diagnostic test to determine b-type natriuretic peptide (BNP) levels for use in clinical evaluation of children treated for CCD. Studies to aid in the development of additional diagnostic tests are underway.
- Improve post-surgical therapy. Many children facing CCD receive long-term treatment with anti-coagulants. The TERM lab is working to develop advanced anti-coagulation therapies based on the novel biomaterials used in the lab.
The Nemours Cardiac Center engages in clinical research in three areas: clinical research in congenital heart disease, basic research, and preventive cardiology.C
Clinical Research
Projects in this area relate to outcomes of cardiovascular surgery and interventional cardiology procedures. Projects underway include:
- Studies of innovations in surgical technique for palliation of hypoplastic left heart syndrome
- The influence of early postoperative management on morbidity following congenital cardiac surgery
- Studies to assess outcomes of heart defects corrected at very young ages
The Center continues to actively enroll patients in the inception cohorts of studies of left ventricular outflow tract obstruction, pulmonary conduits and tricuspid atresia.
The Cardiac Center is also involved in two multi-center trials:
- The Clarinet trial, which is a prospective, randomized, multi-center, double-blinded trial evaluating the effect of Clopidrogel on the outcome of patients with a single ventricle who receive a systemic-pulmonary artery shunt as part of the initial surgical palliation
- The single ventricle reconstruction trial, the largest and most important surgical study in pediatric cardiac surgery, which is sponsored by the National Heart, Lung, and Blood Institute
In addition, a follow-up phase of this study (SVR II) aimed at collecting data on outcomes at 6 years was launched in 2009.
Dr. Julie Simons, a clinical psychologist, works in collaboration with Behavioral Health to assess the neurodevelopmental and psychosocial outcome of patients who underwent repair of congenital heart defects in infancy. She has recently completed enrollment and neurodevelopmental evaluation of a cohort of patients undergoing cardiac repair with current perfusion techniques.
Also, in collaboration with the Director of Nemours Cardiac Center, Dr. Simons has launched a new study to correlate the intraoperative and early postoperative use of near infrared spectroscopy (NIRS) with neurodevelopmental outcomes after cardiac surgery.
Lastly, the Cardiac Center has joined a multi-center project aimed at evaluating coping mechanisms among parents of children undergoing cardiac repair early in life.
Dr. Radtke is participating in the Congenital Cardiovascular Interventional Study Consortium with a current project comparing surgery versus balloon angioplasty and stent placement for aortic coarctation. Dr. Radtke is also participating in the Midatlantic Group Interventional Cardiology Consortium, a registry designed as a comprehensive framework for quality assurance, short and long-term outcome analysis of catheter interventions.
Dr. Radtke is the principal investigator at Alfred I. duPont for two new multi-center FDA device trials:
- The post-market approval study of the Amplatzer muscular VSD occluder that is used for non-surgical or “minimally invasive” closure of muscular ventricular septal defects
- The pivotal approval study of the new Amplatzer duct occluder II that is used for non-surgical closure of small to moderate patent ductus arteriosus. Recent publications and presentations have centered on the impact of new approaches to neonatal management of hypoplastic left heart syndrome, Fontan completion in infancy, and on early repair of tetralogy of Fallot.
Basic Research
Dr. Takeshi Tsuda is a Physician-Scientist on the funded NIH COBRE initiative (#1 P20 RR020173-01) for a mouse model of myocardial injury, assessment of the response to injury, and the development of heart failure. This model is to delineate the molecular signaling pathways that regulate ventricular remodeling following ischemic myocardial injury. This year, Dr. Tsuda completed work on an AHA Beginning Grant in Aid for 2 years (#0665433U) to investigate the molecular mechanisms that regulate the transition from compensatory hypertrophy to ventricular remodeling under pressure overload.
Dr. Tsuda’s primary interest is in the role of the extracellular matrix in the signal transduction that induces heart failure. Dr. Tsuda has not only established molecular biologic and physiologic tools to evaluate the heart’s response and recovery to acute injury in vivo, but also developed an in vitro cell culture system to test the specific hypotheses being addressed. Dr. Tsuda has sponsored a project in the new statewide INBRE grant and is developing translational projects with collaborators from around the country for the assessment of the role of extracellualr matrix in heart failure.
Drs. McCulloch and Derby are collaborating with Drs. William Santamore and Ofer Barnea from Temple University and Tel Aviv University on a computer simulation model of the fetal cardiovascular circulation as well as circulation in patients with single ventricles. This basic science application will allow theoretical modeling of physiologic problems unique to congenital heart disease and may suggest future treatment strategies for complex circulatory disturbances.
Preventive Cardiology
Preventive cardiology research has taken a new direction in the past year. Dr. Gidding recently received a $450,000 grant from GlaxoSmithKline to conduct a trial of fish oil treatment of elevated triglycerides in children. He is participating as co-investigator with the imaging laboratory at Johns Hopkins in a successful grant application to be the coordinating center for the year 25 echocardiography examination in the CARDIA study.
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Nemours News
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Berends Appointed Director, Cardiac Center Nursing
Wilma Berends, RN, has been appointed Director, Cardiac Center Nursing at Nemours/Alfred I. duPont Hospital for Children.

