MD Jobayer Hossain, PhD

Sr Research Scientist

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

I am a Senior Research Scientist in the Department of Biomedical Research and the Director of the Biostatistics Program at Nemours, as well as an Adjunct Associate Professor in the Department of Applied Economics and Statistics at University of Delaware. My research interests focus on the innovative application of statistical methods to ensure effectiveness in studies involving clinical, epidemiological, and public health research. As the director of the Biostatistics Program, I lead core activities of the theoretical development and innovative application of statistical methods, and provide statistical direction and technical oversight for projects of interdisciplinary collaboration that require statistical input. Specifically, I provide expert-level input to research projects of various sizes, scopes, phases and levels of funding, and provide statistical support to clinical researchers in designing clinical trials, pre-clinical, epidemiological, and survey studies; power and sample size calculation; randomization; data management; and data analysis; and in authoring the statistical section in research protocols, manuscripts, abstracts, and presentations. I have broad research collaborations with clinicians of many different disciplines, and I have led several of studies as principal investigator (PI) including a NIH COBRE pilot grant to investigate early childhood growth patterns using Nemours electronic health records. I also provide training and education on skills of statistics and analytical software at Nemours and affiliated institutions. My own and collaborative work have produced illustrative methodological innovation and explored etiologic pathways and health trends in diverse pediatric populations to improve the health of children affected by a broad range of diseases, disorders, and health conditions, including pediatric obesity, asthma, allergy, diabetes, and cancer. In addition to routine statistical modeling of data, my current research interests include tracking changes in health trajectories over time (e.g., childhood growth trajectories); identifying refraction of health trajectories around critical events (e.g., medical diagnosis); recognizing hidden patterns in longitudinal changes (e.g., growth patterns) or in correlated variables of overlapping as well as contrasting characteristics in cross-sectional data; forming classes of distinct patterns; and identifying individual- as well as community-level demographic, clinical and other features responsible for diverse trajectories. In my career as a statistician, I have many years of experience applying statistical methodology in clinical, epidemiological, pharmaceutical, and financial settings. The scope of my work includes cross-sectional, longitudinal, case-control, and survey data analyses; application of linear and nonlinear regressions in both cross-sectional and longitudinal settings; mixed and random effects; multilevel analysis; survival analysis; time series analysis; statistical learning and cluster analysis; principal component and factor analyses; propensity score; bootstrap; cross-validation; G-estimation; and other parametric and nonparametric statistical techniques. I have participated in clinical trials (phases I-IV) of efficacy, safety, pharmacokinetic, and pharmacodynamics in many therapeutic areas. I provide training and education on skills in statistical analysis, study design, as well as for analytical software programs including SAS, R, S-Plus, SPSS, M-Plus, and STATA to researchers, medical fellows, research associates, and junior biostatisticians at Nemours through classes, seminars, and one-on-one meetings. I also teach graduate and undergraduate statistics courses as an adjunct faculty member of Applied Economics and Statistics at the University of Delaware. My graduate course work covered a wide range of areas in statistics (classical and Bayesian), biostatistics, population science (demography), data mining and statistical learning, mathematics (numerical mathematics and optimization theory), probability (measure theoric, stochastic, and inferential statistics), computer sciences, and economics. I am a lead or co-author for 121 published articles and more than 200 published abstracts and presentations. I am actively involved in scientific, educational, and research activities. My academic training and extensive work experience in statistics, epidemiology, and biometry have prepared me to be an effective research and teaching faculty in relevant fields.

Medical/Dental School

  • B. Sc. (Honors) - Jahangirnagar University, Statistics, 1989
  • M.A. - Ball State University, Statistics, 2001
  • M.Sc - Jahangirnagar University, Statistics, 1991
  • Ph.D. - Southern Methodist University, Statistics, 2006

  • Impact of intravenous fluid administration on cardiac output and oxygenation during cardiopulmonary resuscitation; Intensive Care Medicine Experimental; (2023).

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  • SOCIO-DEMOGRAPHIC-ECONOMIC STATUS IS A SIGNIFICANT PREDICTOR OF COVID-19 RELATED HOSPITALIZATIONS IN CHILDREN AND YOUNG ADULTS: POPULATION LEVEL ANALYSIS BASED ON US NATIONAL COVID COHORT COLLABORATIVE (N3C) DATA; Journal of the American College of Cardiology; (2023).

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  • Cardiopulmonary Exercise Testing Characterizes Silent Cardiovascular Abnormalities in Asymptomatic Pediatric Cancer Survivors; Pediatric Cardiology; (2023).

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  • A novel application of finite Gaussian mixture model (GMM) using real and simulated biomarkers of cardiovascular disease to distinguish adolescents with and without obesity; Communications in Statistics: Case Studies, Data Analysis and Applications; (2023).

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  • Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy; Ear, Nose & Throat Journal; (2022).

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  • PSAT108 Impact of recombinant human growth hormone (rhGH) on skeletal muscle strength, power, endurance and agility in prepubertal boys with significant short stature: preliminary results; Journal of the Endocrine Society; (2022).

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  • Frailty model to account for the heterogeneity in the long-term cancer data: An application to the SEER data for determining race-ethnic disparity in pediatric acute myeloid leukemia survival; Trends in Cancer Research; (2022).

  • THE IMPACT OF COVID-19 PANDEMIC ISOLATION MEASURES ON PEDIATRIC ASTHMA ADMISSIONS; Annals of Allergy, Asthma & Immunology; (2022).

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  • Utilising pneuRIP device in determining the adequacy of respiratory support when weaning high-flow nasal cannula in paediatric patients with acute respiratory distress: A pilot study; Journal of Paediatrics and Child Health; (2022).

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  • Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex; Cancers; (2022).

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  • Impact of Plans of Safe Care on Prenatally Substance Exposed Infants; The Journal of Pediatrics; (2022).

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  • A Feasibility Study to Measure Protection Offered by a Coronavirus Disease 2019 Intubation Enclosure; Journal of Clinical Engineering; (2022).

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  • Antibiotics prior to age 2 years have limited association with preschool growth trajectory.; International journal of obesity (2005); (2022).

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  • Impact of dysglycemia and obesity on the brain in adolescents with and without type 2 diabetes: A pilot study; Pediatric Diabetes; (2022).

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  • Durability of Changes in Biomarkers of Cardiometabolic Disease: 1-Year Family-Based Intervention in Children with Obesity; Metabolic Syndrome and Related Disorders; (2021).

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  • Epidemiology and prognostic factors of pediatric brain tumor survival in the US: Evidence from four decades of population data; Cancer Epidemiology; (2021).

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  • Caregiver Risk Factors Associated with Sudden Unexpected Infant Deaths; Pediatrics; (2021).

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  • Association of Positional Plagiocephaly and Developmental Delay Within a Primary Care Network.; Journal of developmental and behavioral pediatrics : JDBP; (2021).

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  • Glycosaminoglycans as Biomarkers for Mucopolysaccharidoses and Other Disorders; Diagnostics; (2021).

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  • Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model; Intensive Care Medicine Experimental; (2021).

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  • Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study; The Journal of Clinical Endocrinology & Metabolism; (2021).

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  • Validation of the Healthcare Transition Outcomes Inventory for Young Adults With Type 1 Diabetes.; Journal of pediatric psychology; (2020).

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  • The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation.; Intensive care medicine experimental; (2020).

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  • Impact of a Personalized Audit and Feedback Intervention on Antibiotic Prescribing Practices for Outpatient Pediatric Community-Acquired Pneumonia.; Clinical pediatrics; (2020).

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  • Factors Associated with Child-Welfare Involvement among Prenatally Substance-Exposed Infants.; The Journal of pediatrics; (2020).

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  • Can Short Bouts of Exercise ("Exercise Snacks") Improve Body Composition in Adolescents with Type 1 Diabetes? A Feasibility Study; Hormone Research in Paediatrics; (2020).

  • Quality Improvement Project to Promote Identification and Treatment of Children with Obesity Admitted to Hospital; American Journal of Medical Quality; (2020).

  • Poster Abstracts; Obesity; (2020).

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  • Association of Positional Plagiocephaly and Developmental Delay Within a Primary Care Network; Journal of Developmental & Behavioral Pediatrics; (2020).

  • Surveillance imaging in pediatric ependymoma.; Pediatric blood & cancer; (2020).

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  • Use of pulse contour technology for continuous blood pressure monitoring in pediatric patients.; Blood pressure monitoring; (2020).

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  • Post-Hoc Mixture Models of the Best Linear Unbiased Predictors (BLUP) from Linear Mixed Effects Models to Classify Longitudinal Data with Haphazardly Spaced Intervals: A Simulation Study; JMS Proceedings; (2020).

  • Classification of Distinct Trajectories in Longitudinal Data With Irregular Spaced Intervals: Heterogeneous Linear Mixed Model vs. Mixture Modeling of BLUPs From Linear Mixed Model; JSM Proceedings; (2019).

  • Promoting Adherence to Influenza Vaccination Recommendations in Pediatric Practice; Journal of Primary Care & Community Health; (2019).

  • Patient features and survival of pediatric aplastic anemia in the USA: a large institution experience.; Journal of public health (Oxford, England); (2019).

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  • Changes in Myokines in Youths With Severe Obesity Following Roux-en-Y Gastric Bypass Surgery.; JAMA surgery; (2019).

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  • Effects of age, sex, race/ethnicity, and allergy status in obesity-related pediatric asthma.; Pediatric pulmonology; (2019).

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  • Promoting Adherence to Influenza Vaccination Recommendations in Pediatric Practice.; Journal of primary care & community health; (2019).

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  • Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial; Annals of the American Thoracic Society; (2019).

  • Factors Associated With Pickup of Pediatric Discharge Prescriptions.; Hospital pediatrics; (2019).

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  • Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods; Contemporary clinical trials; (2019).

  • Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial.; Annals of the American Thoracic Society; (2019).

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  • Postoperative Pain and 14-Day Recovery in Children Undergoing Adenotonsillectomy: Low Thermal Damage Device Versus Electrosurgery.; Ear, nose, & throat journal; (2019).

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  • Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates.; Scientific reports; (2019).

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  • Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods.; Contemporary clinical trials; (2019).

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  • Early Antibiotic Exposure and Weight Outcomes in Young Children. ; Pediatrics; (2018).

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  • Being Overweight or Obese and the Development of Asthma.; Pediatrics; (2018).

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  • Poor adherence to early childhood blood pressure measurement guidelines in a large pediatric healthcare system.; Pediatric nephrology (Berlin, Germany); (2018).

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  • Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome.; Clinical endocrinology; (2018).

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  • Survival differences in childhood and young adult acute myeloid leukemia: A cross-national study using US and England data.; Cancer epidemiology; (2018).

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  • Cryptorchidism in Boys With Cerebral Palsy Is Associated With the Severity of Disease and With Co-Occurrence of Other Congenital Anomalies.; Frontiers in endocrinology; (2018).

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  • Integrating childhood obesity resources into the patient-centered medical home: Provider perspectives in the United States.; Journal of child health care : for professionals working with children in the hospital and community; (2018).

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  • Analysis of Nonstationary Time Series with Time Varying Frequencies; CreateSpace Independent ; (2018).

  • Measures of respiratory inductance plethysmography (RIP) in children with neuromuscular disease.; Pediatric pulmonology; (2018).

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  • Analysis of Nonstationary Time Series with Time Varying Frequencies; CreateSpace Independent ; (2018).

  • Electronic Gaming Characteristics Associated with Class 3 Severe Obesity in Youth Who Attend the Pediatric Weight Management Programs of the COMPASS Network.; Childhood obesity (Print); (2018).

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  • Roux-en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexin.; Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery; (2018).

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  • Vitamin D Status and Cardiovascular Risk in Obesity: Effect of Physical Activity in Nonvitamin D Supplemented Adolescents.; Metabolic syndrome and related disorders; (2018).

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  • Surgical site infections in neonates are independently associated with longer hospitalizations.; Journal of perinatology : official journal of the California Perinatal Association; (2017).

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  • Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesity.; Pediatric obesity; (2017).

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  • Relationship between Teach-back and patient-centered communication in primary care pediatric encounters.; Patient education and counseling; (2017).

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  • Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study.; The Journal of clinical endocrinology and metabolism; (2017).

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  • Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia at Children's Hospitals and General Hospitals Following National Guideline Release; Open forum infectious diseases; (2017).

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  • Problem Video Gaming Among Children Enrolled in Tertiary Weight Management Programs.; Cyberpsychology, behavior and social networking; (2017).

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  • Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes.; Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies; (2017).

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  • Impact of Personalized Audit and Feedback on Management of Pediatric Outpatient Community-Acquired Pneumonia; Open forum infectious diseases; (2017).

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  • Socioeconomic status (SES) and childhood acute myeloid leukemia (AML) mortality risk: Analysis of SEER data.; Cancer epidemiology; (2016).

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  • Pruritus from allergy skin tests in children: Comparing remedies.; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology; (2016).

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  • Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?; Nutrition (Burbank, Los Angeles County, Calif.); (2016).

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  • Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature.; The Journal of clinical endocrinology and metabolism; (2016).

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  • Safety of using real-time sensor glucose values for treatment decisions in adolescents with poorly controlled type 1 diabetes mellitus: a pilot study.; Pediatric diabetes; (2016).

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  • Comparing incidence of emergence delirium between sevoflurane and desflurane in children following routine otolaryngology procedures.; Minerva anestesiologica; (2016).

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  • Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution?; Thorax; (2016).

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  • Decreased Circulating Levels of Spexin in Obese Children.; The Journal of clinical endocrinology and metabolism; (2016).

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  • User Evaluation of a Dynamic Arm Orthosis for People With Neuromuscular Disorders.; IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society; (2015).

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  • Sex disparity in childhood and young adult acute myeloid leukemia (AML) survival: Evidence from US population data.; Cancer epidemiology; (2015).

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  • Correlates of type and quantity of child communication during pediatric subspecialty encounters.; Patient education and counseling; (2015).

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  • Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.; Molecular cancer; (2015).

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  • Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.; Cancer epidemiology; (2015).

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  • Candida species bloodstream infections in hospitalised children: A 10-year experience.; Journal of paediatrics and child health; (2015).

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  • Implications and impact of prior authorization policy on vancomycin use at a tertiary pediatric teaching hospital.; The Pediatric infectious disease journal; (2015).

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  • Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls.; The Journal of clinical endocrinology and metabolism; (2015).

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  • Di-sulfated Keratan Sulfate as a Novel Biomarker for Mucopolysaccharidosis II, IVA, and IVB.; JIMD reports; (2015).

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  • Trends of fluoroquinolone-resistant Escherichia coli amongst urinary isolates in children: a 10 year surveillance study.; Journal of medical microbiology; (2015).

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  • Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years.; Journal of biometrics & biostatistics; (2015).

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  • Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.; Pediatric diabetes; (2014).

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  • A randomized, double blind, placebo-controlled pilot trial of the safety and efficacy of atorvastatin in children with elevated low-density lipoprotein cholesterol (LDL-C) and type 1 diabetes.; Pediatric diabetes; (2014).

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  • 384Impact of a New Restriction Policy: Limiting Duration of Therapy of Restricted Antimicrobials to 7 Days in a Pediatric Hospital; Open forum infectious diseases; (2014).

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  • Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures.; The Journal of allergy and clinical immunology; (2014).

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  • Audio-video recording of health care encounters for pediatric chronic conditions: observational reactivity and its correlates.; Journal of pediatric psychology; (2014).

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  • A double-blind randomized trial of fish oil to lower triglycerides and improve cardiometabolic risk in adolescents.; The Journal of pediatrics; (2014).

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  • Characterization of pediatric acute lymphoblastic leukemia survival patterns by age at diagnosis.; Journal of cancer epidemiology; (2014).

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  • The quest for the best metric of antibiotic use and its correlation with the emergence of fluoroquinolone resistance in children.; The Pediatric infectious disease journal; (2014).

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  • Concomitant fundoplication increases morbidity of gastrostomy tube placement.; Journal of pediatric surgery; (2014).

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  • Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16.; Pulmonary pharmacology & therapeutics; (2013).

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  • Behavioral Medicine, Clinical Nutrition, Education, and Exercise.; Diabetes; (2013).

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  • Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat.; Journal of pediatric endocrinology & metabolism : JPEM; (2012).

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  • Altered infant feeding patterns in boys with acquired nonsyndromic cryptorchidism.; Birth defects research. Part A, Clinical and molecular teratology; (2012).

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  • Surfactant administration prior to one lung ventilation: physiological and inflammatory correlates in a piglet model.; Pediatric pulmonology; (2011).

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  • Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics.; Chest; (2011).

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  • Pharmacokinetics and pharmacodynamics of oral and transdermal 17β estradiol in girls with Turner syndrome.; The Journal of clinical endocrinology and metabolism; (2011).

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  • Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trial.; The Journal of pediatrics; (2010).

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  • Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons.; The Journal of biological chemistry; (2010).

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  • Impact of androgen deprivation therapy on racial/ethnic disparities in the survival of older men treated for locoregional prostate cancer.; Cancer control : journal of the Moffitt Cancer Center; (2009).

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  • The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure.; Toxicological sciences : an official journal of the Society of Toxicology; (2008).

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