Timothy Michael Maul, CCP

Perfusionist

Nemours Children's Hospital, Florida 6535 Nemours Parkway Orlando, FL 32827

Biography

Timothy M. Maul, CCP, FPP, PhD is a Perfusionist and Senior Research Scientist at Nemours Children's Health Florida. He is an adjunct faculty member of the Department of Bioengineering at the University of Pittsburgh and an Associate Professor of Medical Education at the College of Medicine, University of Central Florida. Dr. Maul received his bachelor's and doctoral degrees in Bioengineering in 2001 and 2007, respectively, at the University of Pittsburgh where he was a member of the undergraduate Honors College and inducted into Tau Beta Pi Engineering Honors Society. During graduate school, he received both an American Heart Association and a Ruth R. Kirschstein National Service Award for his research focused on the mechanobiology of stem cells for tissue engineering applications. After completing his PhD, Dr. Maul received a Hartwell Postdoctoral Fellowship for Pediatric Ventricular Assist Device (VAD) Development. After completing his postdoctoral fellowship in 2011, Dr. Maul was promoted to Research Assistant Professor at the University of Pittsburgh School of Medicine. His research focused on Extracorporeal Membrane Oxygenation (ECMO) and VAD device development and clinical utilization. Dr. Maul was also the primary instructor for Artificial Organs and a key instructor for Bioengineering Methods, two undergraduate courses at the University of Pittsburgh Department of Bioengineering. In addition to his research, Dr. Maul became the ECMO Coordinator for UPMC Children's Hospital and received a certificate as a Clinical Perfusionist from the UPMC Shadyside School of Perfusion in 2013. During this time, he published several peer reviewed manuscripts and book chapters on topics related to ECMO and VADs and became a key member of the Extracorporeal Life Support Organization (ELSO) simulation team. In 2016, Dr. Maul joined Nemours Children's Health Florida to start a pediatric Cardiac Surgery program under the direction of Dr. Peter Wearden, who had served as his mentor during his postdoctoral fellowship and was the medical director of the ECMO program at UPMC Children's Hospital. In his roles as a Perfusionist and Senior Research Scientist, Dr. Maul continues his clinical and research work on pediatric cardiac surgical patients in addition to providing research and statistical support for all departments within Nemours Children's Health Florida. In 2021, he joined the faculty of the College of Medicine at the University of Central Florida where he mentors medical students interested in research related to pediatric cardiac surgery. Dr. Maul's research interests remain focused on pediatric cardiac surgery and medical device development. He maintains an adjunct faculty appointment at the University of Pittsburgh Department of Bioengineering where he continues to mentor and serve on thesis committees for students pursuing graduate degrees in bioengineering.

Education

  • BS - University of Pittsburgh, Bioengineering, 2001
  • CCP - UPMC Shadyside School of Perfusion, Perfusion Technology, 2013
  • PhD - University of Pittsburgh, Bioengineering, 2007

  • Anticoagulation
  • Bioengineering
  • Database Design
  • Ecmo
  • Statistics
  • Thrombosis
  • Vad

  • Idiopathic Pericardial Effusions in Children: Workup and Final Diagnoses; Pediatric Cardiology; (2024).

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  • Changes in Bronchiolitis Characteristics During the COVID-19 Pandemic: A Description of Pediatric Emergency Department Visits in a Community Hospital, 2019-2021; Clinical Pediatrics; (2024).

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  • Pediatric extracorporeal life support for refractory status asthmaticus: ELSO Registry trends from the past decade; Artificial Organs; (2023).

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  • Response to Hemostatic Complications During Neonatal Extracorporeal Membrane Oxygenation: Roller Pump and Centrifugal Pump Driven Circuits; ASAIO Journal; (2023).

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  • Extracorporeal Life Support for Status Asthmaticus: Early Outcomes in Teens and Young Adults; ASAIO Journal; (2022).

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  • Development of a Standardized Assessment of Simulation-based Extracorporeal Membrane Oxygenation Educational Courses; ATS Scholar; (2022).

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  • Middle ear effusion prevalence at time of tympanostomy before and during COVID-19 pandemic; International Journal of Pediatric Otorhinolaryngology; (2021).

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  • A shifting landscape: Practice patterns and outcomes of cystic fibrosis and non‐cystic fibrosis pediatric lung transplantation; Pediatric Transplantation; (2021).

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  • A Minimal Opioid Postoperative Management Protocol in Congenital Cardiac Surgery: Safe and Effective; Seminars in Thoracic and Cardiovascular Surgery; (2021).

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  • Aortic Valve Replacement in Young and Middle-Aged Adults: Current and Potential Roles of TAVR; Annals of Thoracic Surgery; (2021).

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  • Prevalence of prescription medication use in preschool-age children seen in pediatric otolaryngology; International Journal of Pediatric Otorhinolaryngology; (2020).

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  • Blood pressure measurements during intraoperative pediatric scoliosis surgery; Saudi Journal of Anaesthesia; (2020).

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  • Impact of Induction Immunosuppression on Early Outcomes in Pediatric Lung Transplantation; The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation; (2020).

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  • Impact of circuit size on coagulation and hemolysis complications in pediatric extracorporeal membrane oxygenation; ASAIO Journal; (2020).

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  • Development and evaluation of an EHR-based computable phenotype for identification of pediatric Crohn's disease patients in a National Pediatric Learning Health System; Learning Health Systems; (2020).

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  • Early arrhythmia burden in pediatric cardiac surgery fast-track candidates: Analysis of incidence and risk factors; Progress in Pediatric Cardiology; (2019).

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  • National Practice Patterns and Early Outcomes of Aortic Valve Replacement in Children and Teens; Annals of Thoracic Surgery; (2019).

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  • Surfactant administration during pediatric cardiac extracorporeal membrane oxygenation; ASAIO Journal; (2019).

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  • Predictors of Poor Outcomes in Pediatric Venoarterial Extracorporeal Membrane Oxygenation; World journal for pediatric & congenital heart surgery; (2018).

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  • Limiting Dietary Sugar Improves Pediatric Sinonasal Symptoms and Reduces Inflammation; Journal of Medicinal Food; (2018).

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  • Paracorporeal lung devices: Thinking outside the box; Frontiers in Pediatrics; (2018).

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  • Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device; Journal of Thoracic and Cardiovascular Surgery; (2018).

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  • Principles of Mechanical Cardiopulmonary Support; Heart Failure in the Child and Young Adult: From Bench to Bedside; (2018).

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  • Pediatric ECMO after drowning: Neuroprotective strategies; Progress in Pediatric Cardiology; (2018).

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  • Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass; Critical care medicine; (2017).

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  • American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock; Critical Care Medicine; (2017).

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  • Mechanical Circulatory Support and Antithrombotic Therapy: Looking for the Holy Grail; ASAIO Journal; (2017).

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  • Residents' understanding of adult congenital heart disease; Congenital Heart Disease; (2017).

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  • The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary; Pediatric Critical Care Medicine; (2017).

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  • Adversity in Neonates and Children with Pulmonary Artery Hypertension: The Role of ECMO; ASAIO Journal; (2016).

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  • Dual chamber stent prevents organ malperfusion in a model of donation after cardiac death; Surgery (United States); (2016).

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  • Measuring hassles in adults with congenital heart disease; Progress in Pediatric Cardiology; (2016).

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  • Mechanical blood trauma in assisted circulation: Sublethal RBC damage preceding hemolysis; International Journal of Artificial Organs; (2016).

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  • Development of Risk Indices for Neonatal Respiratory Extracorporeal Membrane Oxygenation; ASAIO Journal; (2016).

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  • Patient Preference and Perception of Care Provided by Advance Nurse Practitioners and Physicians in Outpatient Adult Congenital Clinics; Congenital Heart Disease; (2015).

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  • Current and future status of adult congenital training in North America; American Journal of Cardiology; (2015).

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  • Surfactant administration during pediatric extracorporeal membrane oxygenation; ASAIO Journal; (2015).

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  • Biocompatibility assessment of the centrimag-novalung adult ECMO circuit in a model of acute pulmonary hypertension; ASAIO Journal; (2014).

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  • Neurodevelopmental outcomes after pediatric cardiac ECMO support; Frontiers in Pediatrics; (2013).

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  • Obstacles Encountered in Developing an Adult Congenital Heart Disease Program; American Journal of Cardiology; (2013).

  • Shock-related anxiety and sexual function in adults with congenital heart disease and implantable cardioverter-defibrillators; Heart Rhythm; (2013).

  • Assessment of the Cerebral Circulation in Adults with Coarctation of the Aorta; Congenital Heart Disease; (2013).

  • In vivo PEG modification of vascular surfaces for targeted delivery; Journal of Vascular Surgery; (2012).

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  • Activated partial thromboplastin time is a better trending tool in pediatric extracorporeal membrane oxygenation; Pediatric Critical Care Medicine; (2012).

  • FREQUENCY AND OUTCOMES OF NEUROLOGICAL ABNORMALITIES IN INFANTS AND CHILDREN REQUIRING EXTRA-CORPOREAL MEMBRANE OXYGENATION (ECMO); Critical Care Medicine; (2012).

  • BRAIN CT GRAY:WHITE MATTER RATIO ASSOCIATION WITH CEREBRAL EDEMA IN CHILDREN REQUIRING ECMO POST-CARDIAC ARREST; Critical Care Medicine; (2012).

  • In Vitro and In Vivo Performance Evaluation of the Second Developmental Version of the PediaFlow Pediatric Ventricular Assist Device; Cardiovascular Engineering and Technology; (2011).

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  • Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation; Biomechanics and Modeling in Mechanobiology; (2011).

  • Platelet activation in ovines undergoing sham surgery or implant of the second generation pediaflow pediatric ventricular assist device; Artificial Organs; (2011).

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  • Platelet activation after implantation of the Levitronix PediVAS in the ovine model; ASAIO Journal; (2011).

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  • Pre-clinical Implants of the Levitronix PediVAS<sup>®</sup> Pediatric Ventricular Assist Device: Strategy for Regulatory Approval; Cardiovascular Engineering and Technology; (2011).

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  • In silico design and in-vivo analysis of the PediaFlow™ pediatric ventricular assist device; ASME 2011 Summer Bioengineering Conference, SBC 2011; (2011).

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  • The PediaFlow (TM) Pediatric Ventricular Assist Device; Journal of Heart and Lung Transplantation; (2011).

  • A Biohybrid Artificial Lung Prototype With Active Mixing of Endothelialized Microporous Hollow Fibers; Biotechnology and Bioengineering; (2010).

  • Optimization of Ultrasound Contrast Agents With Computational Models to Improve Selection of Ligands and Binding Strength; Biotechnology and Bioengineering; (2010).

  • In Vivo Assessment of a Tissue-Engineered Vascular Graft Combining a Biodegradable Elastomeric Scaffold and Muscle-Derived Stem Cells in a Rat Model; Tissue Engineering Part a; (2010).

  • PediaFlow™ Maglev Ventricular Assist Device: A Prescriptive Design Approach; Cardiovascular Engineering and Technology; (2010).

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  • Vascular differentiation of stem cells by mechanical forces; Hemodynamics and Mechanobiology of Endothelium; (2010).

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  • Optimization of Targeted Microbubbles With Adhesive Dynamics Modeling; Journal of the American College of Cardiology; (2009).

  • Characterization of the response of bone marrow derived progenitor cells to cyclic strain: Implications for vascular tissue engineering applications (vol 10, pg 361, 2004); Tissue Engineering Part a; (2008).

  • The pediaflow pediatric ventricular assist device; 2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition; (2008).

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  • Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation; Biomechanics and Modeling in Mechanobiology; (2007).

  • A new experimental system for the extended application of cyclic hydrostatic pressure to cell culture; Journal of Biomechanical Engineering-Transactions of the Asme; (2007).

  • Mechanical stimulation differentially controls proliferation, morphology, and vascular gene and protein expression in mesenchymal progenitor cells; Circulation; (2007).

  • Mechanical stimulation induces morphological and phenotypic changes in bone marrow-derived progenitor cells within a three-dimensional fibrin matrix; Journal of Biomedical Materials Research Part a; (2007).

  • Mesenchymal progenitor cells differentially respond to mechanical stimulation: Morphology, proliferation, geneand protein expression; Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007; (2007).

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  • Molecular aspects of vascular tissue engineering.; Frontiers in bioscience : a journal and virtual library; (2005).

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  • Characterization of the Response of Bone Marrow-Derived Progenitor Cells to Cyclic Strain: Implications for Vascular Tissue-Engineering Applications; Tissue Engineering; (2004).

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  • Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: Implications for vascular tissue-engineering applications; Tissue Engineering; (2004).

  • Crosslinking of collagen gels by transglutaminase; Journal of Biomedical Materials Research Part a; (2004).

  • The influence of cyclic strain on the differentiation of rat bone marrow derived mesenchymal stem cells to vascular smooth muscle; Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; (2002).

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