Howard Mark Katzenstein, MD

Physician - Moonlighter

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Fellowship

  • Pediatric Hematology/Oncology - Ann & Robert H. Lurie Children's Hospital, 1997

Internship Residency

  • Pediatrics - Childrens Hospital of Pittsburgh UPMC, 1994

Medical/Dental School

  • MD - University of Illinois at Chicago College of Med, 1991

Board Certifications

  • American Board of Pediatrics/Hematology-Oncology

  • Clinical Trials
  • Embryonal Sarcoma
  • Hepatoblastoma
  • Hepatocellular Carcinoma
  • Liver Tumors
  • Neuroblastoma
  • Pediatric Oncology
  • Phase I
  • Phase Ii
  • Rhabdoid Tumor
  • Yttrium-90

  • Outcomes of children with well-differentiated fetal hepatoblastoma treated with surgery only: Report from Children's Oncology Group Trial, AHEP0731; Journal of Pediatric Surgery; (2022).

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  • Liver Tumors; Pediatric Oncology; (2022).

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  • Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults; Journal of Hepatology; (2022).

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  • Small Cell Undifferentiated Histology Does Not Adversely Affect Outcome in Hepatoblastoma: A Report From the Children's Oncology Group (COG) AHEP0731 Study Committee; Journal of Clinical Oncology; (2022).

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  • Doxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group study; Cancer; (2022).

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  • Multiscale-omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target; npj Precision Oncology; (2021).

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  • Irradiating residual disease to 30 Gy with proton therapy in pediatric mediastinal Hodgkin lymphoma; International Journal of Particle Therapy; (2021).

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  • Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults; bioRxiv; (2021).

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  • A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma; Pediatric Blood & Cancer; (2021).

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  • Neonatal Liver Tumors; Clinics in Perinatology; (2021).

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  • Pediatric HCT in Florida (2014 -2016): A report from the FPBCC; Pediatric Transplantation; (2021).

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  • Vaping the venom: Oral cavity cancer in a young adult with extensive electronic cigarette use; Pediatrics; (2021).

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  • Successful use of transarterial radioembolization with yttrium-90 (TARE-Y90) in two children with hepatoblastoma; Pediatric Blood & Cancer; (2020).

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  • A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors; Pediatric Blood and Cancer; (2020).

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  • Concurrent Imatinib Dosing with High-dose Methotrexate Leads to Acute Kidney Injury and Delayed Methotrexate Clearance in Pediatric Patients with Philadelphia Chromosome-positive B-Cell Acute Lymphoblastic Leukemia; Journal of Pediatric Hematology/Oncology; (2020).

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  • Erratum: Chemotherapeutic approaches for newly diagnosed hepatoblastoma: Past, present, and future strategies (Journal of Clinical Oncology (2012) 59 (809-812) DOI: 10.1002/pbc.24219); Journal of Clinical Oncology; (2020).

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  • Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: A report from the children's oncology group AHEP 0731 liver tumor committee; Journal of Pediatric Surgery; (2020).

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  • Irinotecan, temozolomide, and dinutuximab with GM-CSF in children with refractory or relapsed neuroblastoma: A report from the children's Oncology group; Journal of Clinical Oncology; (2020).

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  • Routine Surveillance Imaging Is Associated with Improved Postrelapse Survival in Patients with Ewing Sarcoma; Journal of Adolescent and Young Adult Oncology; (2020).

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  • Cardiac-Sparing Whole Lung IMRT in Patients With Pediatric Tumors and Lung Metastasis: Final Report of a Prospective Multicenter Clinical Trial; International Journal of Radiation Oncology Biology Physics; (2019).

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  • Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial; The Lancet Oncology; (2019).

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  • Maintaining outstanding outcomes using response- And biology-based therapy for intermediate-risk neuroblastoma: A report from the children's oncology group study ANBL0531; Journal of Clinical Oncology; (2019).

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  • Proton therapy following induction chemotherapy for pediatric and adolescent nasopharyngeal carcinoma; Pediatric Blood & Cancer; (2019).

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  • Priapism in a 13-year-old boy; Pediatrics in Review; (2018).

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  • High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler with Aicardi Syndrome and Malignant Sacrococcygeal Teratoma; Journal of Pediatric Hematology/Oncology; (2018).

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  • Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 study committee; Cancer; (2017).

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  • Prolonged isotretinoin in ultra high-risk neuroblastoma; Journal of Pediatric Hematology/Oncology; (2017).

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  • Pulmonary relapse of osteosarcoma following presentation with a pneumomediastinum and localized disease at diagnosis; Journal of Pediatric Hematology/Oncology; (2017).

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  • Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma; Sarcoma; (2017).

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  • Characterization of pulmonary metastases in children with hepatoblastoma treated on children's oncology group protocol AHEP0731 (The treatment of children with all stages of hepatoblastoma): A report from the children's oncology group; Journal of Clinical Oncology; (2017).

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  • Heart transplantation for anthracycline cardiomyopathy: Pump up the volume; Pediatric Transplantation; (2017).

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  • Respiratory difficulties in children with underlying asthma during immunotherapy for high-risk neuroblastoma; Journal of Pediatric Hematology/Oncology; (2017).

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  • Comparative pharmacokinetics, safety, and tolerability of two sources of ch14.18 in pediatric patients with high-risk neuroblastoma following myeloablative therapy; Cancer Chemotherapy and Pharmacology; (2016).

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  • Cause and effect: the etiology of pediatric hepatocellular carcinoma and the role for liver transplantation; Pediatric Transplantation; (2016).

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  • 131I-Metaiodobenzylguanidine with intensive chemotherapy and autologous stem cell transplantation for high-risk neuroblastoma: A new approaches to neuroblastoma therapy (NANT) phase II study; Biology of Blood and Marrow Transplantation; (2015).

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  • Outcomes after radiation therapy to metastatic sites in patients with stage 4 neuroblastoma; Journal of Pediatric Hematology/Oncology; (2015).

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  • Towards an international pediatric liver tumor consensus classification: Proceedings of the Los Angeles COG liver tumors symposium; Modern Pathology; (2014).

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  • Children's oncology Group's 2013 blueprint for research: Rare tumors; Pediatric Blood and Cancer; (2013).

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  • A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors; Clinical Cancer Research; (2013).

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  • Dose-intensive cisplatin for hepatoblastoma: Have you heard?; The Lancet Oncology; (2013).

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  • Outcomes for patients with congenital hepatoblastoma; Pediatric Blood and Cancer; (2013).

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  • Chemotherapeutic approaches for newly diagnosed hepatoblastoma: Past, present, and future strategies; Pediatric Blood and Cancer; (2012).

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  • Colorectal adenocarcinoma: A pediatric case review with a focus on mismatch repair gene mutations and E-cadherin expression; Pediatric and Developmental Pathology; (2012).

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  • Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization; Fetal and Pediatric Pathology; (2012).

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  • Gemcitabine and docetaxel (GEMDOX) for the treatment of relapsed and refractory pediatric sarcomas; Pediatric Blood and Cancer; (2012).

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  • Successful treatment of an adolescent with locally advanced cervicovaginal clear cell adenocarcinoma using definitive chemotherapy and radiotherapy; Journal of Pediatric Hematology/Oncology; (2012).

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  • Tandem stem cell rescue as consolidation therapy for high-risk neuroblastoma; Pediatric Blood and Cancer; (2012).

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  • Treatment of hepatoblastoma: The North American cooperative group experience; Frontiers in Bioscience - Elite; (2012).

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  • A phase I study of zoledronic acid and low-dose cyclophosphamide in recurrent/refractory neuroblastoma: A new approaches to neuroblastoma therapy (NANT) study; Pediatric Blood and Cancer; (2011).

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  • Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: A report from the Children's Oncology Group; Journal of Clinical Oncology; (2011).

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  • Polycythemia in an infant secondary to granulocyte transfusions; Pediatric Blood and Cancer; (2011).

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  • Primary congenital infantile fibrosarcoma of the heart: The first confirmed case; Annals of Thoracic Surgery; (2011).

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  • The use of zoledronic acid in pediatric cancer patients; Pediatric Blood and Cancer; (2011).

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  • Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: A review of eleven cases; Pediatric and Developmental Pathology; (2011).

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  • Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis; Fetal and Pediatric Pathology; (2011).

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  • Unusual presentation of rosai-dorfman disease (RDD) in the bone in adolescents; Fetal and Pediatric Pathology; (2011).

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  • Intracavitary cisplatin therapy for pediatric malignancies; Pediatric Blood and Cancer; (2010).

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  • Irinotecan as maintenance therapy in high-risk hepatoblastoma; Pediatric Blood and Cancer; (2010).

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  • NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary; Pediatric and Developmental Pathology; (2010).

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  • Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: A report of the intergroup hepatoblastoma study p9645 as a part of the Children's Oncology Group; Cancer; (2009).

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  • Anaplastic large cell neuroblastoma; Pediatric and Developmental Pathology; (2009).

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  • Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors; Pediatric Blood and Cancer; (2009).

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  • Predictive power of pretreatment prognostic factors in children with hepatoblastoma: A report from the Children's Oncology Group; Pediatric Blood and Cancer; (2009).

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  • Phase I and pharmacokinetic study of cetuximab and irinotecan in children with refractory solid tumors: A study of the pediatric oncology experimental therapeutic investigators' consortium; Journal of Clinical Oncology; (2009).

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  • Neuroblastoma; Current Problems in Cancer; (2009).

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  • Extracorporeal life support for support of children with malignancy and respiratory or cardiac failure: The extracorporeal life support experience; Critical Care Medicine; (2009).

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  • Excellent Local Control From Radiation Therapy for High-Risk Neuroblastoma; International Journal of Radiation Oncology Biology Physics; (2009).

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  • Atypical hemolytic uremic syndrome responsive to steroids and intravenous immune globulin; Pediatric Blood and Cancer; (2009).

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  • Redefining the role of doxorubicin for the treatment of children with hepatoblastoma; Journal of Clinical Oncology; (2008).

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  • Intensity-Modulated Radiotherapy With Use of Cone-Down Boost for Pediatric Head-and-Neck Rhabdomyosarcoma; International Journal of Radiation Oncology Biology Physics; (2008).

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  • Surgical resection of pulmonary metastatic lesions in children with hepatoblastoma; Journal of Pediatric Surgery; (2007).

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  • Predictive value of staging systems in hepatoblastoma [11]; Journal of Clinical Oncology; (2007).

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  • Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17- demethoxygeldanamycinin pediatric patients with recurrent or refractory solid tumors: A pediatric oncology experimental therapeutics investigators consortium study; Clinical Cancer Research; (2007).

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  • Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma; Journal of Clinical Oncology; (2006).

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  • Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects; Cancer Letters; (2005).

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  • Scintigraphic response by123I-metaiodobenzylguanidine scan correlates with event-free survival in high-risk neuroblastoma; Journal of Clinical Oncology; (2004).

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  • Gastrointestinal stromal tumors arising from the stomach: A report of three children; Journal of Pediatric Surgery; (2004).

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  • The role of angiogenesis in neuroblastoma: Clinical implications; American Journal of Cancer; (2003).

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  • Results of little or no treatment for lymphocyte-predominant Hodgkin disease in children and adolescents; Journal of Pediatric Hematology/Oncology; (2003).

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  • Pathologic quiz case: Ovarian mass in a 2-year-old girl presenting with pleural effusions.; Archives of pathology & laboratory medicine; (2003).

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  • Metastatic malignant rhabdoid tumor of the liver treated with tandem high-dose therapy and autologous peripheral blood stem cell rescue [2]; Medical and Pediatric Oncology; (2003).

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  • Increased microvascular density predicts relapse in Wilms' tumor; Journal of Pediatric Surgery; (2003).

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  • Fibrolamellar hepatocellular carcinoma in children and adolescents; Cancer; (2003).

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  • Advances in the diagnosis and treatment of neuroblastoma; Oncologist; (2003).

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  • Novel therapeutic approaches in the treatment of children with hepatoblastoma; Journal of Pediatric Hematology/Oncology; (2002).

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  • Treatment of unresectable and metastatic hepatoblastoma: A Pediatric Oncology Group phase II study; Journal of Clinical Oncology; (2002).

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  • Treatment of high-risk neuroblastoma with triple-tandem high-dose therapy and stem-cell rescue: Results of the Chicago Pilot II study; Journal of Clinical Oncology; (2002).

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  • Hepatocellular carcinoma in children and adolescents: Results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study; Journal of Clinical Oncology; (2002).

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  • Treatment and outcome of 83 children with intraspinal neuroblastoma: The pediatric oncology group experience; Journal of Clinical Oncology; (2001).

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  • Immunotherapeutic strategies in neuroblastoma: Antitumoral activity of deglycosylated Ricin a conjugated anti-GD2 antibodies and anti-CD3xanti-GD2 bispecific antibodies; Medical and Pediatric Oncology; (2001).

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  • Antiangiogenic therapy inhibits human neuroblastoma growth; Medical and Pediatric Oncology; (2001).

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  • MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN; Journal of Clinical Oncology; (2000).

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  • Angiogenesis in neuroblastoma [2] (multiple letters); Journal of Clinical Oncology; (2000).

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  • Effectiveness of the angiogenesis inhibitor TNP-470 in reducing the growth of human neuroblastoma in nude mice inversely correlates with tumor burden; Clinical Cancer Research; (1999).

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  • Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: The pediatric oncology group experience - A pediatric oncology group study; Journal of Clinical Oncology; (1998).

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  • Advances in the diagnosis and treatment of neuroblastoma; Current Opinion in Oncology; (1998).

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  • Haploidentical related umbilical cord blood stem cell transplant in a child with acute non-lymphocytic leukemia; Bone Marrow Transplantation; (1997).

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  • Treatment of poor-risk neuroblastoma patients with high-dose chemotherapy and autologous peripheral stem cell rescue; Bone Marrow Transplantation; (1997).

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