Xuyi Yue

Research Scientist

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Focus on development of PET radiopharmaceuticals for implementing in both pre-clinic and clinic for brain disorders and oncology. Oversee a GMP lab with strong troubleshooting and programming capability. Respected and self-motivated professional with over 10 years of experience in translating PET radiotracers from bench to clinical investigation. Proven strong track record in conducting and managing cutting-edge research with over 50 publications and 1800+ citations. Strong work ethics and works effectively on multiple collaborative projects in a dynamic team.

Medical/Dental School

  • Lanzhou University, Chemistry, 2004
  • Ph.D. - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 2009

  • Radiochemistry, Organic Chemistry, Nuclear Medicine, Molecular Imaging

  • Special Issue "In Vivo Nuclear Molecular Imaging in Drug Development and Pharmacological Research"; Pharmaceuticals; (2023).

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  • Abusive Head Trauma Animal Models: Focus on Biomarkers; International Journal of Molecular Sciences; (2023).

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  • Unravelling neuroinflammation in abusive head trauma with radiotracer imaging; Pediatric Radiology; (2021).

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  • Birth-related subdural hemorrhage: prevalence and imaging morphology; Pediatric Radiology; (2021).

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  • Radiosynthesis of 1-(2-[18f]fluoroethyl)-l-tryptophan using a one-pot, two-step protocol; Journal of Visualized Experiments; (2021).

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  • Automated production of 1-(2-[18F]fluoroethyl)-L-tryptophan for imaging of tryptophan metabolism; Applied Radiation and Isotopes; (2020).

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  • PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model; Scientific Reports; (2020).

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  • Automated production of a N-methyl-D-aspartate receptor radioligand [ 18 F]GE179 for clinical use; Applied Radiation and Isotopes; (2019).

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  • Enzymatic activity of palmitoyl-protein thioesterase-1 in serum from schizophrenia significantly associates with schizophrenia diagnosis scales; Journal of Cellular and Molecular Medicine; (2019).

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  • Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis; Journal of Neuroimmunology; (2018).

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  • Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands; Bioorganic and Medicinal Chemistry Letters; (2018).

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  • Kinetic modeling of [ 18 F]VAT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain; Journal of Neurochemistry; (2018).

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  • Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter; Bioorganic and Medicinal Chemistry Letters; (2018).

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  • In Vivo Characterization of Two 18 F-Labeled PDE10A PET Radioligands in Nonhuman Primate Brains; ACS Chemical Neuroscience; (2018).

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  • Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation; Bioorganic and Medicinal Chemistry Letters; (2018).

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  • Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease; European Journal of Pharmacology; (2018).

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  • Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques; Molecular Imaging and Biology; (2018).

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  • Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (--)-[18F]TZ3108 in rodent and the nonhuman primate brain; Bioorganic and Medicinal Chemistry; (2017).

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  • PET study of sphingosine-1-phosphate receptor 1 expression in response to vascular inflammation in a rat model of carotid injury; Molecular Imaging; (2017).

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  • Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate; Org. Biomol. Chem.; (2017).

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  • Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter; Applied Radiation and Isotopes; (2016).

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  • Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates; Nuclear Medicine and Biology; (2016).

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  • Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates; Pharmacology Research and Perspectives; (2016).

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  • Design, Synthesis, and in Vitro and in Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer; Journal of Medicinal Chemistry; (2016).

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  • PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis; Molecular Imaging and Biology; (2016).

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  • A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression; Organic and Biomolecular Chemistry; (2015).

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  • Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject; NeuroImage; (2015).

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  • Lack of neuroinflammation in the HIV-1 transgenic rat: An [18F]-DPA714 PET imaging study; Journal of Neuroinflammation; (2015).

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  • Radiation dosimetry of [18F]VAT in nonhuman primates; EJNMMI Research; (2015).

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  • Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter; Bioorganic and Medicinal Chemistry; (2015).

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  • PET and NIR optical imaging using self-illuminating 64Cu-doped chelator-free gold nanoclusters; Biomaterials; (2014).

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  • Dye-Loaded Ferritin Nanocages for Multimodal Imaging and Photothermal Therapy; Advanced Materials; (2014).

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  • Longitudinal PET imaging of muscular inflammation using 18F-DPA-714 and 18F-alfatide II and differentiation with tumors; Theranostics; (2014).

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  • Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS; Molecular Pharmaceutics; (2014).

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  • One-pot two-step radiosynthesis of a new 18F-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging; Molecular Pharmaceutics; (2014).

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  • A symmetrical fluorous dendron-cyanine dye-conjugated bimodal nanoprobe for quantitative 19f MRI and NIR fluorescence bioimaging; Advanced Healthcare Materials; (2014).

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  • PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714; European Journal of Nuclear Medicine and Molecular Imaging; (2014).

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  • Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy; Theranostics; (2014).

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  • [18F]DPA-714 PET imaging of AMD3100 treatment in a mouse model of stroke; Molecular Pharmaceutics; (2014).

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  • PH-sensitive fluorescent dyes: Are they really ph-sensitive in cells?; Molecular Pharmaceutics; (2013).

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  • Development of a new thiol site-specific prosthetic group and its conjugation with [Cys40]-exendin-4 for in vivo targeting of insulinomas; Bioconjugate Chemistry; (2013).

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  • Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging; Biomaterials; (2013).

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  • Synthesis and characterization of fluorinated conjugates of albumin; Journal of Fluorine Chemistry; (2013).

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  • Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy; Biomaterials; (2013).

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  • Avoiding steric congestion in dendrimer growth through proportionate branching: A twist on da Vincis rule of tree branching; Journal of Organic Chemistry; (2012).

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  • Fluorine-Containing Chiral Drugs; Chiral Drugs: Chemistry and Biological Action; (2011).

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  • Palladium-catalyzed cross-coupling of ethyl α-bromo-α- fluoroacetate with arylboronic acids: Facile synthesis of α-aryl-α- fluoroacetate; Synthesis; (2010).

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  • A practical approach to synthesize the C(9)-C(24) fragment of (+)-discodermolide; Chinese Journal of Chemistry; (2010).

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  • Cu(II)-mediated methylthiolation of aryl C-H bonds with DMSO; Organic Letters; (2010).

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  • Total synthesis of gem-difluoromethylenated analogues of pironetin; Synthesis; (2010).

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  • Highly diastereoselective zn/sncl2-mediated gem- difluoroallylation of chiral hydrazones; Organic Letters; (2009).

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  • Metal-mediated gem-difluoroallylation of N-acylhydrazones: Highly efficient synthesis of α,α-difluorohomoallylic amines; Chinese Journal of Chemistry; (2009).

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  • Synthesis of 2',3'-dideoxy-6',6'-difluoro-3'-azanucleosides; Journal of Fluorine Chemistry; (2008).

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  • Synthesis of gem-difluoromethylenated goniodiol; Chinese Journal of Organic Chemistry; (2008).

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  • Synthesis of a series of novel 2',3'-dideoxy-6',6'-difluoro-3'-thionucleosides; Tetrahedron; (2007).

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