Suzanne McCahan, PhD

Assistant Research Scientist

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Dr. McCahan came to Nemours from Fox Chase Cancer Center where she was a postdoctoral associate. Currently, she is an assistant research scientist in Nemours Biomedical Research. She is also a research assistant professor at Thomas Jefferson Medical College. She and H. Timothy Bunnell, PhD formed the nucleus of the Nemours Bioinformatics Core Facility when it began in 2003. Dr. McCahan's research includes use of genomics to understand and treat childhood diseases such as juvenile idiopathic arthritis, cryptorchidism and rare genetic disorders. Currently this includes using microarrays and high throughput sequencing to examine global gene expression, DNA copy number variation and single nucleotide polymorphism. In addition, she engages in development of custom applications for data management management and administrates the Nemours installation of REDCap.

Medical/Dental School

  • ScB - Brown University, Biochemistry,

  • Bioinformatics/Clinical Informatics
  • Genomics/Metabolomics/Proteomics
  • Molecular Biology

  • Schultz, C. L., McCahan, S. M., Lewis, A. M., Bunnell, H. T., & Alderfer, M. A. (2021). Online patient portal use by caregivers in pediatric oncology: Are we widening sociodemographic disparities? Pediatric Blood and Cancer, 68(12). doi:10.1002/pbc.29373

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  • Simonds, M. M., Schlefman, A. R., McCahan, S. M., Sullivan, K. E., Rose, C. D., & Brescia, A. M. C. (2021). The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes. Pediatric Rheumatology, 19(1). doi:10.1186/s12969-021-00556-8

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  • Simonds, M. M., Schlefman, A. R., McCahan, S. M., Sullivan, K. E., Rose, C. D., & Brescia, A. M. C. (2020). Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation. Pediatric Rheumatology, 18(1). doi:10.1186/s12969-020-00483-0

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  • Miller, R. E., Brown, D. S., Keith, S. W., Hegarty, S. E., Setty, Y., Campbell, C. M., & Stuart, M. (2019). Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities. British Journal of Haematology, 185(5), 925-934. doi:10.1111/bjh.15876

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  • Brescia, A. M. C., Simonds, M. M., McCahan, S. M., Sullivan, K. E., & Rose, C. D. (2018). Prior to extension, transcriptomes of fibroblast-like synoviocytes from extended and polyarticular juvenile idiopathic arthritis are indistinguishable. Pediatric Rheumatology, 16(1). doi:10.1186/s12969-017-0217-6

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  • Gopalakrishnapillai, A., Kolb, E. A., McCahan, S. M., & Barwe, S. P. (2017). Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia. Leukemia Research, 58, 91-97. doi:10.1016/j.leukres.2017.05.004

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  • Antal, H., Bunnell, H. T., McCahan, S. M., Pennington, C., Wysocki, T., & Blake, K. V. (2017). A cognitive approach for design of a multimedia informed consent video and website in pediatric research. Journal of Biomedical Informatics, 66, 248-258. doi:10.1016/j.jbi.2017.01.011

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  • Rossi, S. L., Lumpkin, C. J., Harris, A. W., Holbrook, J., Gentillon, C., McCahan, S. M., & Butchbach, M. E. R. (2016). Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. Biochemical and Biophysical Research Communications, 479(2), 319-324. doi:10.1016/j.bbrc.2016.09.068

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  • Beck, C. R., Carvalho, C. M. B., Banser, L., Gambin, T., Stubbolo, D., Yuan, B., & Lupski, J. R. (2015). Complex Genomic Rearrangements at the PLP1 Locus Include Triplication and Quadruplication. PLoS Genetics, 11(3). doi:10.1371/journal.pgen.1005050

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  • Blake, K., Holbrook, J. T., Antal, H., Shade, D., Bunnell, H. T., McCahan, S. M., & Wysocki, T. (2015). Use of mobile devices and the internet for multimedia informed consent delivery and data entry in a pediatric asthma trial: Study design and rationale. Contemporary Clinical Trials, 42, 105-118. doi:10.1016/j.cct.2015.03.012

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  • Barthold, J. S., Pugarelli, J., MacDonald, M. L., Ren, J., Adetunji, M. O., Polson, S. W., & ERobbins, A. K. (2015). Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat. Molecular Human Reproduction, 22(1), 18-34. doi:10.1093/molehr/gav060

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