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- Judith L. Ross, MD, MD
Nemours Children's Hospital, Delaware
1600 Rockland Road
Wilmington,
DE
19803
Biography
My research goals have been to dissect the clinical, genetic, and neurobiological pathways related to X and Y chromosome disorders including Klinefelter syndrome (47,XXY), XYY syndrome, and Turner syndrome. For the male X-chromosome disorder, Klinefelter syndrome, I successfully initiated and completed a recent NINDS-funded clinical trial investigating the effects of early androgen replacement on motor function, cognition, and brain imaging. The results of this study will provide significant evidence-based recommendations about childhood androgen replacement in boys with testicular failure and prevention of obesity and cardiovascular morbidities in this at risk population. In boys with XYY, we hypothesized that the increased autism risk is related to increased Y chromosome gene copy number and over-expression of Y-linked genes related to brain development and function.
Education & Training
Fellowship
Developmental Endocrinology - National Institutes of Health, 1983
Internship Residency
Pediatrics - Children's Hospital of Pittsburgh, 1980
Medical/Dental School
- BA - Wellesley College, Molecular Biology, 1972
- MD - University of Chicago Pritzker School of Medicine, Medicine, 1977
Board Certifications
- American Board of Pediatrics/General Pediatrics
- American Board of Pediatrics/Endocrinology
- Diabetes
- Endocrinology
- Genetics
- Pediatrics
- Knight, L., Pahud, B. A., Scheffler, M., Euteneuer, J. C., Allen, C., Ross, J., & the Environmental Influences on Child Health Outcomes (ECHO) Institutional Development Award (IDeA) States Pediatric Clinical Trials Network. (2022). Capacity Building in a New Clinical Trials Network through Inter-Network Collaboration. Journal of Pediatrics, 240, 5-8. doi:10.1016/j.jpeds.2021.04.062
View Full Publication - Knight, L., Pahud, B. A., Scheffler, M., Euteneuer, J. C., Allen, C., Ross, J., & the Environmental Influences on Child Health Outcomes (ECHO) Institutional Development Award (IDeA) States Pediatric Clinical Trials Network. (2022). Capacity Building in a New Clinical Trials Network through Inter-Network Collaboration. Journal of Pediatrics, 240, 5-8. doi:10.1016/j.jpeds.2021.04.062
View Full Publication - Savendahl, L., Polak, M., Backeljauw, P., Blair, J. C., Miller, B. S., Rohrer, T. R., & Ross, J. (2021). Long-Term Safety of Growth Hormone Treatment in Childhood: Two Large Observational Studies: NordiNet IOS and ANSWER. Journal of Clinical Endocrinology and Metabolism, 106(6), 1728-1741. doi:10.1210/clinem/dgab080
View Full Publication - Merhar, S. L., Ounpraseuth, S., Devlin, L. A., Poindexter, B. B., Young, L. W., Berkey, S. D., & the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network and the NIH Environmental Influences on Child Health Outcomes (ECHO) Program Institutional Development Awards States Pediatric Clinical Trials Network. (2021). Phenobarbital and clonidine as secondary medications for neonatal opioid withdrawal syndrome. Pediatrics, 147(3). doi:10.1542/PEDS.2020-017830
View Full Publication - Aksglaede, L., Davis, S., Ross, J. L., & Juul, A. (2021). Congenital Causes of Hypergonadotropic Hypogonadism: Anorchia and Klinefelter Syndrome. In Trends in Andrology and Sexual Medicine (bll 127-145). doi:10.1007/978-3-030-80015-4_8
- Roberts, T. P. L., Bloy, L., Miller, J. S., Blaskey, L., & Ross, J. (2021). Decreased levels of y-aminobutyric acid in temporal lobe of children with 47,XYY syndrome. NeuroReport, 541-547. doi:10.1097/WNR.0000000000001628
View Full Publication - Chen, D., Strang, J. F., Kolbuck, V. D., Rosenthal, S. M., Wallen, K., Waber, D. P., & Garofalo, R. (2020). Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth. Transgender Health, 5(4), 246-257. doi:10.1089/trgh.2020.0006
- Annett, R. D., Chervinskiy, S., Chun, T. H., Cowan, K., Foster, K., Goodrich, N., & Atz, A. M. (2020). IDeA States Pediatric Clinical Trials Network for Underserved and Rural Communities. Pediatrics, 146(4). doi:10.1542/peds.2020-0290
View Full Publication - Davis, S. M., Bloy, L., Roberts, T. P. L., Kowal, K., Alston, A., Tahsin, A., & Ross, J. L. (2020). Testicular function in boys with 47,XYY and relationship to phenotype. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 184(2), 371-385. doi:10.1002/ajmg.c.31790
View Full Publication - Tartaglia, N., Howell, S., Davis, S., Kowal, K., Tanda, T., Brown, M., & Ross, J. (2020). Early neurodevelopmental and medical profile in children with sex chromosome trisomies: Background for the prospective eXtraordinarY babies study to identify early risk factors and targets for intervention. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 184(2), 428-443. doi:10.1002/ajmg.c.31807
View Full Publication - Aksglaede, L., Davis, S. M., Ross, J. L., & Juul, A. (2020). Minipuberty in Klinefelter syndrome: Current status and future directions. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 184(2), 320-326. doi:10.1002/ajmg.c.31794
View Full Publication - Bizzell, E., Ross, J., Rosenthal, C., Dumont, R., & Schaaf, R. (2020). Sensory Features as a Marker of Autism Spectrum Disorders. Journal of Autism and Developmental Disorders, 50(6), 2240-2246. doi:10.1007/s10803-019-03948-8
View Full Publication - Mauras, N., Torres-Santiago, L., Santen, R., Mericq, V., Ross, J., Colon-Otero, G., & Blair, I. A. (2019). Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome. Clinical Endocrinology, 90(1), 155-161. doi:10.1111/cen.13869
View Full Publication - Conradt, E., Flannery, T., Aschner, J. L., Annett, R. D., Croen, L. A., Duarte, C. S., & Lester, B. M. (2019). Prenatal opioid exposure: Neurodevelopmental consequences and future research priorities. Pediatrics, 144(3). doi:10.1542/peds.2019-0128
View Full Publication - Bloemeke, J., Balacano Valdez, R., Mauras, N., Mericq, V., Ross, J., Permuy, J., & Bullinger, M. (2019). Psychometric performance of the Quality of Life in Short Stature Youth (QoLISSY) questionnaire in a randomized open-label comparator trial in idiopathic short stature. Journal of Pediatric Endocrinology and Metabolism. doi:10.1515/jpem-2019-0137
View Full Publication - Foland-Ross, L. C., Ross, J. L., & Reiss, A. L. (2019). Androgen treatment effects on hippocampus structure in boys with Klinefelter syndrome. Psychoneuroendocrinology, 100, 223-228. doi:10.1016/j.psyneuen.2018.09.039
View Full Publication - Bullinger, M., Bloemeke, J., Mericq, V., Sommer, R., Gaete, X., Ross, J. L., & Mauras, N. (2019). Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase Inhibitors. Hormone Research in Paediatrics, 90(6), 381-392. doi:10.1159/000496353
View Full Publication - Bloy, L., Ku, M., Edgar, J. C., Miller, J. S., Blaskey, L., Ross, J., & Roberts, T. P. L. (2019). Auditory evoked response delays in children with 47,XYY syndrome. NeuroReport, 30(7), 504-509. doi:10.1097/WNR.0000000000001233
View Full Publication - Matsuzaki, J., Bloy, L., Blaskey, L., Miller, J., Kuschner, E. S., Ku, M., & Roberts, T. P. L. (2019). Abnormal Auditory Mismatch Fields in Children and Adolescents with 47,XYY Syndrome. Developmental Neuroscience, 41(1-2), 123-131. doi:10.1159/000500799
View Full Publication - Savendahl, L., Polak, M., Backeljauw, P., Blair, J., Miller, B. S., Rohrer, T. R., & Ross, J. (2019). Treatment of Children with GH in the United States and Europe: Long-Term Follow-Up from NordiNet(R) IOS and ANSWER Program. Journal of Clinical Endocrinology and Metabolism, 104(10), 4730-4742. doi:10.1210/jc.2019-00775
View Full Publication - Davis, S. M., Lahlou, N., Cox-Martin, M., Kowal, K., Zeitler, P. S., & Ross, J. L. (2018). Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys with Klinefelter Syndrome. Journal of Clinical Endocrinology and Metabolism, 103(9), 3449-3455. doi:10.1210/jc.2018-00682
View Full Publication - Rapaport, R., Lee, P. A., Ross, J. L., Saenger, P., Ostrow, V., & Piccoli, G. (2018). Three years of growth hormone therapy in children born small for gestational age: Results from the answer program. Endocrine Connections, 7(10), 1096-1104. doi:10.1530/EC-18-0286
- Benabbad, I., Rosilio, M., Child, C. J., Carel, J.-C., Ross, J. L., Deal, C. L., & Blum, W. F. (2017). Safety Outcomes and Near-Adult Height Gain of Growth Hormone-Treated Children with SHOX Deficiency: Data from an Observational Study and a Clinical Trial. Hormone Research in Paediatrics, 87(1), 42-50. doi:10.1159/000452973
View Full Publication - Davis, S. M., Cox-Martin, M. G., Bardsley, M. Z., Kowal, K., Zeitler, P. S., & Ross, J. L. (2017). Effects of oxandrolone on cardiometabolic health in boys with klinefelter syndrome: A randomized controlled trial. Journal of Clinical Endocrinology and Metabolism, 102(1), 176-184. doi:10.1210/jc.2016-2904
View Full Publication - Ross, J. L., Kushner, H., Kowal, K., Bardsley, M., Davis, S., Reiss, A. L., & Roeltgen, D. (2017). Androgen Treatment Effects on Motor Function, Cognition, and Behavior in Boys with Klinefelter Syndrome. Journal of Pediatrics, 185, 193-199.e4. doi:10.1016/j.jpeds.2017.02.036
View Full Publication - Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., & On behalf of the International Turner Syndrome Consensus Group. (2017). Clinical practice guidelines for the care of girls and women with Turner syndrome: Proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. European Journal of Endocrinology, 177(3), G1-G70. doi:10.1530/EJE-17-0430
View Full Publication - Pierce, J. S., Aroian, K., Caldwell, C., Ross, J. L., Lee, J. M., Schifano, E., & Wysocki, T. (2017). The ups and downs of parenting young children with type 1 diabetes: A crowdsourcing study. Journal of Pediatric Psychology, 42(8), 846-860. doi:10.1093/jpepsy/jsx056
View Full Publication - Wysocki, T., Hirschfeld, F., Miller, L., Izenberg, N., Dowshen, S. A., Taylor, A., & Lawson, M. L. (2016). Consideration of Insulin Pumps or Continuous Glucose Monitors by Adolescents With Type 1 Diabetes and Their Parents: Stakeholder Engagement in the Design of Web-Based Decision Aids. Diabetes Educator, 42(4), 395-407. doi:10.1177/0145721716647492
View Full Publication - Davis, S., Howell, S., Wilson, R., Tanda, T., Ross, J., Zeitler, P., & Tartaglia, N. (2016). Advances in the Interdisciplinary Care of Children with Klinefelter Syndrome. In Advances in Pediatrics (Vol 63, bll 15-46). doi:10.1016/j.yapd.2016.04.020
View Full Publication - Davis, S., Lahlou, N., Bardsley, M., Temple, M.-C., Kowal, K., Pyle, L., & Ross, J. (2016). Gonadal function is associated with cardiometabolic health in pre-pubertal boys with Klinefelter syndrome. Andrology, 4(6), 1169-1177. doi:10.1111/andr.12275
View Full Publication - Mauras, N., Ross, J. L., Gagliardi, P., Yu, Y. M., Hossain, J., Permuy, J., & Mericq, V. (2016). Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature. Journal of Clinical Endocrinology and Metabolism, 101(12), 4984-4993. doi:10.1210/jc.2016-2891
View Full Publication - Ross, J. L., Lee, P. A., Gut, R., & Germak, J. (2015). Attaining genetic height potential: Analysis of height outcomes from the ANSWER Program in children treated with growth hormone over 5 years. Growth Hormone and IGF Research, 25(6), 286-293. doi:10.1016/j.ghir.2015.08.006
View Full Publication - Davis, S. M., Rogol, A. D., & Ross, J. L. (2015). Testis Development and Fertility Potential in Boys with Klinefelter Syndrome. Endocrinology and Metabolism Clinics of North America, 44(4), 843-865. doi:10.1016/j.ecl.2015.07.008
View Full Publication - Bullinger, M., Sommer, R., Pleil, A., Mauras, N., Ross, J., Newfield, R., & Quitmann, J. (2015). Evaluation of the american-english quality of life in short stature youth (QoLISSY) questionnaire in the United States. Health and Quality of Life Outcomes, 13(1). doi:10.1186/s12955-015-0236-2
View Full Publication - Rosenfield, R. L., Dimeglio, L. A., Mauras, N., Ross, J., Shaw, N. D., Greeley, S. A. W., & Rhodes, E. T. (2015). Commentary: Launch of a quality improvement network for evidence-based management of uncommon pediatric endocrine disorders: Turner syndrome as a prototype. Journal of Clinical Endocrinology and Metabolism, 100(4), 1234-1236. doi:10.1210/jc.2014-3845
View Full Publication - Mcculloch, M. A., Mauras, N., Canas, J. A., Hossain, J., Sikes, K. M., Damaso, L. C., & Gidding, S. S. (2015). Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus. Pediatric Diabetes, 16(2), 90-97. doi:10.1111/pedi.12241
View Full Publication - Canas, J. A., Ross, J. L., Taboada, M. V., Sikes, K. M., Damaso, L. C., Hossain, J., & Mauras, N. (2015). A randomized, double blind, placebo-controlled pilot trial of the safety and efficacy of atorvastatin in children with elevated low-density lipoprotein cholesterol (LDL-C) and type 1 diabetes. Pediatric Diabetes, 16(2), 79-89. doi:10.1111/pedi.12245
View Full Publication - Ross, J. L., Tartaglia, N., Merry, D. E., Dalva, M., & Zinn, A. R. (2015). Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features. Genes, Brain and Behavior, 14(2), 137-144. doi:10.1111/gbb.12200
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