Amanda Hernan, PhD

Research Scientist

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Education

  • BS, BA - Case Western Reserve University, Biology, Psychology, 2007
  • PhD - Dartmouth College, Experimental and Molecular Medicine (Neuroscience), 2013

  • Attention
  • Cognition
  • Early Life Seizures
  • Epilepsy
  • Prefrontal Cortex

  • Network‐based analysis predicts interacting genetic modifiers from a meta‐mapping study of spike–wave discharge in mice; Genes, Brain and Behavior; (2024).

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  • Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures; Frontiers in Neurology; (2022).

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  • Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures; bioRxiv; (2022).

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  • Fine Spike Timing in Hippocampal-Prefrontal Ensembles Predicts Poor Encoding and Underlies Behavioral Performance in Healthy and Malformed Brains; Cerebral Cortex; (2021).

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  • Distributed dynamic coding for spatial working memory in hippocampal-prefrontal networks; bioRxiv; (2019).

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  • Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus; PLoS ONE; (2018).

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  • Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE; Epilepsia; (2017).

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  • Environmental Enrichment Normalizes Hippocampal Timing Coding in a Malformed Hippocampus; bioRxiv; (2017).

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  • ACTH prevents deficits in fear extinction associated with early life seizures; Frontiers in Neurology; (2016).

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  • Short-range temporal interactions in sleep; Hippocampal spike avalanches support a large milieu of sequential activity including replay; PLoS ONE; (2016).

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  • Antiepileptic drug treatment strategies in neonatal epilepsy; Progress in Brain Research; (2016).

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  • Stimulation of glutamate receptors in the ventral tegmental area is necessary for serotonin-2 receptor-induced increases in mesocortical dopamine release; Neuroscience; (2015).

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  • Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide; Neurobiology of Disease; (2015).

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  • Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH; PLoS ONE; (2014).

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  • Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits; Neurobiology of Disease; (2014).

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  • Altered short-term plasticity in the prefrontal cortex after early life seizures; Neurobiology of Disease; (2013).

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  • Thrombin facilitates seizures through activation of persistent sodium current; Annals of Neurology; (2012).

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  • Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex; Epilepsy and Behavior; (2011).

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