Thomas H Shaffer, PhD

Director of Nemours Res. Lung

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Thomas H. Shaffer, MS.E., Ph.D., is Professor Emeritus of Physiology and Pediatrics. He also holds the position of Professor of Pediatrics at Thomas Jefferson Medical College. Dr. Shaffer received his doctorate from Drexel University in Philadelphia, Pennsylvania. He did postdoctoral work at the University of Pennsylvania School of Medicine where he was promoted to Assistant Professor of Physiology and Medicine. He was recruited as an Associate Professor at Temple University School of Medicine in 1977. Dr. Shaffer has 40 years of experience as an active scientist in pulmonary research with special attention to the needs of the neonatal and pediatric populations. Dr. Shaffer's revolutionary work with treatments for respiratory distress syndrome is known world-wide, and he is considered an international expert in this field. In addition, he is renowned for his work in developmental airway physiology and clinical pulmonary function evaluation in neonates. As the Director of the Center for Pediatric Research, for the last 17 years I have served as the PD/PI of the Center (http://centerforpediatricresearch.org/), which is supported by the NIH NIGMS COBRE program and have been responsible for administering its staff, revenues and research. In addition, I am also the Director of the Center for Pediatric Lung Research, and Associate Director for Biomedical Research - Delaware Valley - at the Alfred I. duPont Hospital for Children of The Nemours Foundation. Furthermore, I hold faculty positions as Professor of Pediatrics at Thomas Jefferson University and Professor of Physiology and Pediatrics at Temple University School of Medicine. Since 1974, I have been continuously supported by NIH grants (34), and academic, corporate and private institutional awards (56 non-NIH). I have published 78 books, chapters, reviews; 306 peer-reviewed manuscripts; and 605 abstracts. I understand translational research, having moved multiple intellectual properties from the "bench top" to the "clinic" and on to "industry". In my faculty roles at Temple University, the University of Pennsylvania, and Thomas Jefferson School of Medicine, I have mentored 45 graduate students and 65 post-doctoral Fellows over a 40 year period. Many of these former students now hold faculty positions in prestigious medical schools. Dr. Shaffer's contribution to the literature has been significant. His clinical manuscripts have been published in Lancet, The New England Journal of Medicine, the Journal of Pediatrics, Pediatrics, Critical Care Medicine and many more highly respected and well-read periodicals. In addition, he has published basic science manuscripts in the Journal of Applied Physiology, the American Journal of Physiology, and the American Journal of Circulatory Research. He serves on the Editorial Boards of three scientific journals and is a journal reviewer for another 22 publications. Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/thomas.shaffer.1/bibliography/46468478/public/?sort=date&direction=descending

Medical/Dental School

  • BS - Drexel University, Mechanical Engineering, 1968
  • MSE - Drexel University, Mechanical Engineering
  • Penn State University State College , Mathematics/Mechanical Engineering, 1968
  • PhD - Drexel University, Mechanical Engineering, 1972

  • Administration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids; Frontiers in Physiology; (2022).

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  • Utilising pneuRIP device in determining the adequacy of respiratory support when weaning high-flow nasal cannula in paediatric patients with acute respiratory distress: A pilot study; Journal of Paediatrics and Child Health; (2022).

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  • Adjustment of high flow nasal cannula rates using real-time work of breathing indices in premature infants with respiratory insufficiency; Journal of Perinatology; (2021).

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  • Automated assessment of thoracic-abdominal asynchrony in patients with morquio syndrome; Diagnostics; (2021).

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  • Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model; Intensive Care Medicine Experimental; (2021).

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  • Machine learning for automatic identification of thoracoabdominal asynchrony in children; Pediatric Research; (2021).

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  • Pulmonary immune cell transcriptome changes in double-hit model of BPD induced by chorioamnionitis and postnatal hyperoxia; Pediatric Research; (2021).

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  • Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy; PLOS ONE; (2020).

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  • A novel noninvasive approach for evaluating work of breathing indices in a developmental rat model using respiratory inductance plethysmography; Scientific Reports; (2020).

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  • DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis; Frontiers in Pediatrics; (2020).

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  • Effects of xenon gas on human airway epithelial cells during hyperoxia and hypothermia; Journal of Neonatal-Perinatal Medicine; (2020).

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  • The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation; Intensive Care Medicine Experimental; (2020).

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  • Age-related ranges of respiratory inductance plethysmography (RIP) reference values for infants and children; Paediatric Respiratory Reviews; (2019).

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  • Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates; Scientific Reports; (2019).

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  • Cover Image, Volume 53, Number 9, September 2018; Pediatric Pulmonology; (2018).

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  • Nebulization of single-chain tissue-type and single-chain urokinase plasminogen activator for treatment of inhalational smoke-induced acute lung injury; Journal of Drug Delivery Science and Technology; (2018).

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  • Impact of endotracheal tube biofilm and respiratory secretions on airway resistance and mechanics of breathing in a neonatal lung model; Journal of Applied Physiology; (2018).

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  • Measures of respiratory inductance plethysmography (RIP) in children with neuromuscular disease; Pediatric Pulmonology; (2018).

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  • Inflammatory Response of Pulmonary Artery Smooth Muscle Cells Exposed to Oxidative and Biophysical Stress; Inflammation; (2018).

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  • Quantitative Analysis of Thoracoabdominal Asynchrony in Pediatric Polysomnography; Journal of Clinical Sleep Medicine; (2018).

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  • A translational cellular model to study the impact of high-frequency oscillatory ventilation on human epithelial cell function; Journal of Applied Physiology; (2017).

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  • Lung Rest during Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes; Pediatric Critical Care Medicine; (2017).

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  • Management of Supplemental Oxygen for Infants with Persistent Pulmonary Hypertension of Newborn: A Survey; American Journal of Perinatology; (2017).

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  • Skeletal dysplasia: Respiratory management during infancy; Respiratory Medicine; (2017).

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  • Upper Airway Structure; Fetal and Neonatal Physiology, 2-Volume Set; (2017).

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  • pneuRIPTM: A novel respiratory inductance plethysmography monitor; Journal of Medical Devices, Transactions of the ASME; (2017).

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  • Design and testing of a novel slot retractor for neonatal frenotomy; Journal of Clinical Engineering; (2016).

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  • High flow nasal heliox improves work of breathing and attenuates lung injury in a newborn porcine lung injury model; Journal of Neonatal-Perinatal Medicine; (2016).

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  • Parental preferences regarding administration of an animal-derived versus a synthetic medication to newborn infants; Journal of Neonatal-Perinatal Medicine; (2016).

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  • Activity of daily living for Morquio A syndrome; Molecular Genetics and Metabolism; (2016).

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  • Prophylactic methylprednisolone to reduce inflammation and improve outcomes from one lung ventilation in children: A randomized clinical trial; Paediatric Anaesthesia; (2015).

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  • Clinical use of nonconventional modes of ventilator support; Pediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice; (2015).

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  • Indications for nonconventional ventilation modes; Pediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice; (2015).

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  • Non-invasive pulmonary function test on Morquio patients; Molecular Genetics and Metabolism; (2015).

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  • Pharmacokinetics of gentamicin by intravenous and intratracheal administrations; 2014 IEEE Signal Processing in Medicine and Biology Symposium, IEEE SPMB 2014 - Proceedings; (2015).

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  • Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation; Pulmonary Pharmacology and Therapeutics; (2015).

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  • High flow nasal cannula (HFNC) with Heliox decreases diaphragmatic injury in a newborn porcine lung injury model; Pediatric Pulmonology; (2014).

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  • The orl rat is more responsive to methacholine challenge than wild type; Pulmonary Pharmacology and Therapeutics; (2014).

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  • Work of breathing indices in infants with respiratory insufficiency receiving high-flow nasal cannula and nasal continuous positive airway pressure; Journal of Perinatology; (2014).

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  • Comparison study of airway reactivity outcomes due to a pharmacologic challenge test: Impulse oscillometry versus least mean squared analysis techniques; Pulmonary Medicine; (2013).

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  • Use of insulin to decrease septic shock-induced myocardial depression in a porcine model; Inflammation; (2013).

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  • Brief mechanical ventilation impacts airway cartilage properties in neonatal lambs; Pediatric Pulmonology; (2012).

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  • Clara cell protein mediates secretion of proteins, IL-8 and IL-6 in human airway epithelial cell line Calu-3 exposed to hyperoxia; Journal of Chemical and Pharmaceutical Research; (2012).

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  • Dosage effects of clara cell 10 kd (cc10) protein on the human airway epithelial cell line Calu-3 under normoxic and hyperoxic conditions; Research Journal of Pharmaceutical, Biological and Chemical Sciences; (2012).

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  • Hyperoxia during one lung ventilation: Inflammatory and oxidative responses; Pediatric Pulmonology; (2012).

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  • Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS; Pediatric Research; (2012).

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  • Neonatal non-invasive respiratory support: Physiological implications; Pediatric Pulmonology; (2012).

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  • Perfluorodecalin lavage of a longstanding lung atelectasis in a child with spinal muscle atrophy; Pediatric Pulmonology; (2012).

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  • Pulmonary function tests in emergency department pediatric patients with acute wheezing/asthma exacerbation; Pulmonary Medicine; (2012).

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  • Respiratory mechanics in an infant with perinatal lethal hypophosphatasia treated with human recombinant enzyme replacement therapy; Pediatric Pulmonology; (2012).

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  • The effects of gas humidification with High-flow nasal cannula on cultured human airway epithelial cells; Pulmonary Medicine; (2012).

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  • Translational research: Matching experimental models with therapeutic interventions; Pediatric Critical Care Medicine; (2012).

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  • Nasal cannula, CPAP, and high-flow nasal cannula: Effect of flow on temperature, humidity, pressure, and resistance; Biomedical Instrumentation and Technology; (2011).

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  • Effect of budesonide in airway epithelial cell line Calu-3 with reduced CFTR function; Journal of Chemical and Pharmaceutical Research; (2011).

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  • Airway injury resulting from repeated endotracheal intubation: Possible prevention strategies; Pediatric Critical Care Medicine; (2011).

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  • Altered properties of human airway epithelial cell line calu-3 with reduced CFTR function; International Journal of Pharmacy and Technology; (2011).

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  • High-flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model; Pediatric Pulmonology; (2011).

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  • Perfluorochemical liquid-adenovirus suspensions enhance gene delivery to the distal lung; Pulmonary Medicine; (2011).

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  • Pregnancy and Outcome of Uterine Allotransplantation and Assisted Reproduction in Sheep; Journal of Minimally Invasive Gynecology; (2011).

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  • Reply letter to: RhinoChill: Do we need perfluorocarbons?; Resuscitation; (2011).

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  • Surfactant administration prior to one lung ventilation: Physiological and inflammatory correlates in a piglet model; Pediatric Pulmonology; (2011).

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  • Protective ventilation to reduce inflammatory injury from one lung ventilation in a piglet model; Paediatric Anaesthesia; (2010).

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  • Prototype hybrid systems for neonatal warming: In vitro comparisons to standard of care devices; Biomedical Instrumentation and Technology; (2010).

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  • Skeletal dysplasias: Evaluation with impulse oscillometry and thoracoabdominal motion analysis; Pediatric Pulmonology; (2010).

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  • Clinical design functions: Round table discussions on the bioengineering of liquid ventilators; ASAIO Journal; (2009).

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  • Developmental differences in the contractile response of isolated ovine tracheal smooth muscle cells; Pediatric Pulmonology; (2009).

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  • Efficacy of Chest Physiotherapy in Pediatric Patients with Acute Asthma Exacerbations; Pediatric Asthma, Allergy and Immunology; (2009).

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  • Heat shock protein 70 secretion by neonatal tracheal tissue during mechanical ventilation: Association with indices of tissue function and modeling; Pediatric Research; (2009).

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  • Research in high flow therapy: Mechanisms of action; Respiratory Medicine; (2009).

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  • Intranasal perfluorochemical spray for preferential brain cooling in sheep; Neurocritical Care; (2008).

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  • Assessment of neonatal ventilation during high-frequency oscillatory ventilation; Pediatric Critical Care Medicine; (2008).

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  • Dissociation between the effects of oxygen and pressure on matrix metalloproteinase-2, -7, and -9 expression in human airway epithelial cells; American Journal of Perinatology; (2008).

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  • Effects of oxygen concentration and exposure time on cultured human airway epithelial cells; Pediatric Critical Care Medicine; (2008).

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  • Low dose methylprednisolone prophylaxis to reduce inflammation during one-lung ventilation; Paediatric Anaesthesia; (2008).

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  • KL4-surfactant (Lucinactant) protects human airway epithelium from hyperoxia; Pediatric Research; (2008).

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  • Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep; ASAIO Journal; (2008).

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  • Perfluorochemical augmented rhSOD delivery attenuates inflammation in the immature lung; Journal of Neonatal-Perinatal Medicine; (2008).

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  • Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome; American Journal of Perinatology; (2008).

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  • An ultrasound imaging method for in vivo tracheal bulk and Young's moduli of elasticity; Journal of Biomechanics; (2007).

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  • Correlation of tracheal smooth function with structure protein during early development; Pediatric Pulmonology; (2007).

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  • Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress; Pediatric Critical Care Medicine; (2007).

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  • Growth and development in a heliox incubator environment: A long-term safety study; Neonatology; (2007).

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  • Sequential alterations of tracheal mechanical properties in the neonatal lamb: Effect of mechanical ventilation; Pediatric Pulmonology; (2007).

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  • Ventilator-induced airway injury: a critical consideration during mechanical ventilation of the infant.; Neonatal network : NN; (2006).

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  • Effects of an intratracheally delivered anti-inflammatory protein (rhCC10) on physiological and lung structural indices in a juvenile model of acute lung injury; Biology of the Neonate; (2006).

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  • The 5th European Symposium on Perfluorocarbon (PFC) application; ASAIO Journal; (2006).

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  • Effects of perfluorochemical evaporative properties on oxygenation during partial liquid ventilation; Pediatrics International; (2006).

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  • Expression of matrix metalloproteinases 2, 7 and 9, and their tissue inhibitors 1 and 2, in developing rabbit tracheae; Biology of the Neonate; (2006).

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  • Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression profiles in tracheal aspirates do not adequately reflect tracheal or lung tissue profiles in neonatal respiratory distress: Observations from an animal model; Pediatric Critical Care Medicine; (2006).

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  • Optimizing the neonatal thermal environment.; Neonatal network : NN; (2006).

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  • Perfluorochemical liquids enhance delivery of superoxide dismutase to the lungs of juvenile rabbits; Pediatric Research; (2006).

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  • Physiologic implications of helium as a carrier gas for inhaled nitric oxide in a neonatal model of Bethanecol-induced bronchoconstriction; Pediatric Critical Care Medicine; (2006).

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  • Pulmonary function assessment in an infant with Barnes syndrome: Proactive evaluation for surgical intervention; Pediatrics; (2006).

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  • The impact of mechanical ventilation on immature airway smooth muscle: Functional, structural, histological, and molecular correlates; Biology of the Neonate; (2006).

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  • A prototype infant incubator for heliox therapy; Biomedical Instrumentation and Technology; (2006).

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  • Cold perfluorochemical-induced hypothermia protects lung integrity in normal rabbits; Biology of the Neonate; (2005).

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  • The neonatal respiratory pump: a developmental challenge with physiologic limitations.; Neonatal network : NN; (2005).

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  • Tracheal gas insufflation as a lung-protective strategy: Physiologic, histologic, and biochemical markers; Pediatric Critical Care Medicine; (2005).

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  • Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury; Critical Care Medicine; (2005).

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  • Safety, pharmacokinetics, and anti-inflammatory effects of intratracheal recombinant human Clara cell protein in premature infants with respiratory distress syndrome; Pediatric Research; (2005).

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  • Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: Physiological, inflammatory, and kinetic profiles; Journal of Applied Physiology; (2005).

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  • Heliox attenuates lung inflammation and structural alterations in acute lung injury; Pediatric Pulmonology; (2005).

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  • Hyperoxia-induced changes in human airway epithelial cells: The protective effect of perflubron; Pediatric Critical Care Medicine; (2005).

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  • Neonatal chest wall suspension splint: A novel and noninvasive method for support of lung volume; Pediatric Pulmonology; (2005).

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  • Pulmonary applications of perfluorochemical liquids: Ventilation and beyond; Paediatric Respiratory Reviews; (2005).

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  • Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: Effect of route of administration; Pediatric Critical Care Medicine; (2005).

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  • Airway structure, function and development in health and disease; Paediatric Anaesthesia; (2004).

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  • Association of interleukin-8 with inflammatory and innate immune components in bronchoalveolar lavage of children with chronic respiratory diseases; Clinica Chimica Acta; (2004).

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  • Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury; Journal of Applied Physiology; (2004).

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  • Feasibility of lung cancer hyperthermia using breathable perfluorochemical (PFC) liquids. Part I: Connective hyperthermia; International Journal of Hyperthermia; (2004).

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  • Feasibility of lung cancer hyperthermia using breathable perfluorochemical (PFC) liquids. Part II: Ultrasound hyperthermia; International Journal of Hyperthermia; (2004).

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  • Respiratory Physiology: Structure, Function, and Integrative Responses to Intervention with Special Emphasis on the Ventilatory Pump; Cardiopulmonary Physical Therapy: A Guide to Practice: Fourth Edition; (2004).

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  • Liquid ventilation: An adjunct for respiratory management; Paediatric Anaesthesia; (2004).

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  • Inhaled nitric oxide therapy in the near-term or term neonate with hypoxic respiratory failure.; Neonatal network : NN; (2004).

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  • Tracheal gas insufflation-augmented continuous positive airway pressure in a spontaneously breathing model of neonatal respiratory distress; Pediatric Pulmonology; (2004).

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  • Protein composition of apical surface fluid from the human airway cell line Calu-3: Effect of ion transport mediators; Clinica Chimica Acta; (2004).

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  • Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3; Biochemical and Biophysical Research Communications; (2004).

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  • Assisted Ventilation: Physiologic Implications and Complications; Fetal and Neonatal Physiology: Third Edition; (2003).

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  • Convective heat transfer during endometrial cryoablation using PFC fluid; Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; (2003).

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  • Liquid Ventilation; Fetal and Neonatal Physiology: Third Edition; (2003).

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  • Long-term tidal liquid ventilation in premature lambs: Physiologic, biochemical and histological correlates; Biology of the Neonate; (2003).

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  • PIV measurement of fluid flow inside a human uterus model for cryoablation; Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; (2003).

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  • Perfluorochemical (PFC) combinations for acute lung injury: An in vitro and in vivo study in juvenile rabbits; Pediatric Research; (2003).

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  • Physiologic effects of CPAP: application and monitoring.; Neonatal network : NN; (2003).

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  • Positive end-expiratory pressure modulates perfluorochemical evaporation from the lungs; Biology of the Neonate; (2003).

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  • Respiratory support; Neonatal Respiratory Disorders, Second Edition; (2003).

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  • Special Ventilatory Techniques And Modalities Ii: Lung Protective Strategies and Liquid Ventilation; Assisted Ventilation of the Neonate; (2003).

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  • Upper Airway Structure: Function, Regulation, and Development; Fetal and Neonatal Physiology: Third Edition; (2003).

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  • Transient heat transfer in human endometrium during cryoablation; Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; (2002).

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  • Physicochemical properties of perfluorochemical liquids influence ventilatory requirements, pulmonary mechanics, and microvascular permeability during partial liquid ventilation following intestinal ischemia/reperfusion injury; Critical Care Medicine; (2002).

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  • Distinct patterns of apoptosis in the lung during liquid ventilation compared with gas ventilation; American Journal of Physiology - Lung Cellular and Molecular Physiology; (2002).

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  • Experimental and numerical studies of heat transfer in human uteri during cryoablation; ASME International Mechanical Engineering Congress and Exposition, Proceedings; (2002).

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  • If art imitates life, can laboratory models imitate clinical disease processes?; Critical Care Medicine; (2002).

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  • Managing our first breaths: a reflection on the past several decades of neonatal pulmonary therapy.; Neonatal network : NN; (2002).

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  • Effects of perfluorochemical distribution and elimination dynamics on cardiopulmonary function; Journal of Applied Physiology; (2001).

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  • A comparison of surfactant delivery with conventional mechanical ventilation and partial liquid ventilation in meconium aspiration injury; Respiratory Medicine; (2001).

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  • Efficacy of specific perfluorocarbons for use in partial liquid ventilation [4] (multiple letters); Critical Care Medicine; (2001).

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  • Intratracheal administration of perfluorochemical-gentamicin suspension: A comparison to intravenous administration in normal and injured lungs; Pediatric Pulmonology; (2001).

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  • Perfluorochemical liquids do not stimulate endothelin-1 or nitric oxide production in human blood leukocytes; Biology of the Neonate; (2001).

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  • Perfluorochemical liquids modulate cell-mediated inflammatory responses; Critical Care Medicine; (2001).

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  • Role of ventilation strategy on perfluorochemical evaporation from the lungs; Journal of Applied Physiology; (2001).

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  • Temperature and heater responses during transition between radiant and incubator thermal environment in newborn preterm lambs; Biology of the Neonate; (2001).

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  • Thermal stability and transition studies with a hybrid warming device for neonates; Journal of Perinatology; (2001).

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  • A perfluorochemical loss/restoration (L/R) system for tidal liquid ventilation; Biomedical Instrumentation and Technology; (2000).

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  • Effects of partial liquid ventilation with perfluorodecalin in the juvenile rabbit lung after saline injury; Critical Care Medicine; (2000).

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  • Liquid ventilation; Seminars in Perinatology; (2000).

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  • Multi-center comparative study of conventional mechanical (CMV) to tidal liquid ventilation (TLV) in oleic acid (OA) injured sheep; Annals of Biomedical Engineering; (2000).

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  • Perfluorochemical elimination from the lungs: Effect of initial dose; Pediatric Pulmonology; (2000).

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  • A method for isolating adult and neonatal airway smooth muscle cells and measuring shortening velocity; Journal of Applied Physiology; (1999).

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  • Airway mechanics in health and disease; New Horizons: Science and Practice of Acute Medicine; (1999).

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  • Effect of single versus multiple dosing on perfluorochemical distribution and elimination during partial liquid ventilation; Pediatric Pulmonology; (1999).

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  • Developmental airway structure and function in health and chronic lung injury; Chronic Lung Disease in Early Infancy; (1999).

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  • Improved pulmonary function after surgical reduction of congenital diaphragmatic hernia in lambs; Journal of Pediatric Surgery; (1999).

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  • Intra-tracheal delivery strategy of gentamicin with partial liquid ventilation; Respiratory Medicine; (1999).

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  • Liquid assisted ventilation update; European Journal of Pediatrics, Supplement; (1999).

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  • Liquid perfluorochemical priming before surfactant therapy: This time the egg really does precede the chicken; Critical Care Medicine; (1999).

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  • Liquid ventilation State-of-the-Art, Part 2; Biomedical Instrumentation and Technology; (1999).

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  • Liquid ventilation state-of-the-art, part I; Biomedical Instrumentation and Technology; (1999).

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  • Liquid ventilation: Clinical experiences; Biomedical Instrumentation and Technology; (1999).

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  • Liquid ventilation: current status.; Pediatrics in review / American Academy of Pediatrics; (1999).

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  • Multifactorial analysis of exchanger efficiency and liquid conservation during perfluorochemical liquid-assisted ventilation; Biomedical Instrumentation and Technology; (1999).

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  • On-line techniques for perfluorochemical vapor sampling and measurement; Biomedical Instrumentation and Technology; (1999).

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  • Software for real-time control of a tidal liquid ventilator; Biomedical Instrumentation and Technology; (1999).

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  • Antenatal triiodothyronine improves neonatal pulmonary function in preterm lambs; Journal of the Society for Gynecologic Investigation; (1998).

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  • Cardiopulmonary interaction during partial liquid ventilation in surfactant-treated preterm lambs; European Journal of Pediatrics; (1998).

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  • Perfluorochemical rescue after surfactant treatment: Effect of perflubron dose and ventilatory frequency; Journal of Applied Physiology; (1998).

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  • Physiologic, biochemical, and histologic correlates associated with tidal liquid ventilation; Pediatric Research; (1998).

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  • Quantitative bronchoscopic assessment of airway collapsibility in newborn lamb tracheae; Pediatric Research; (1998).

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  • Halothane administration during liquid ventilation; Respiratory Medicine; (1997).

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  • Enhanced distribution of adenovirus-mediated gene transfer to lung parenchyma by perfluorochemical liquid; Human Gene Therapy; (1997).

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  • Comparison of perfluorochemical fluids used for liquid ventilation: Effect of endotracheal tube flow resistance; Pediatric Pulmonology; (1997).

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  • Analysis of perfluorochemical elimination from the respiratory system; Journal of Applied Physiology; (1997).

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  • Liquid-assisted ventilation: From concept to clinical application; Seminars in Neonatology; (1997).

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  • Morphometrics of normal and hypoplastic lungs in preterm lambs with gas and partial liquid ventilation; Pediatric Surgery International; (1997).

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  • Partial liquid ventilation in critically ill infants receiving extracorporeal life support. Philadelphia Liquid Ventilation Consortium.; Pediatrics; (1997).

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  • Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome,Partielle Flüssigkeitsventilation mit Perflubron bei Frühgeborenen mit schwerem Atemnotsyndrom; Pneumologie; (1997).

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  • Pulmonary administration of gentamicin during liquid ventilation in a newborn lamb lung injury model.; Pediatrics; (1997).

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  • A comparison of intratracheal and intravenous administration of gentamicin during liquid ventilation; European Journal of Pediatrics; (1997).

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  • Liquid ventilation in premature lambs: Uptake, biodistribution and elimination of perfluorodecalin liquid; Reproduction, Fertility and Development; (1996).

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  • Comparison of natural surfactant and briefliquid ventilation rescue treatment in very immature lambs; Neonatology; (1996).

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  • Infant thoracic surgery: Procedure-dependent pulmonary response; Journal of Pediatric Surgery; (1996).

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  • Liquid assisted ventilation: An alternative ventilatory strategy for acute meconium aspiration injury; Pediatric Pulmonology; (1996).

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  • Liquid ventilation: An alternative ventilation strategy for management of neonatal respiratory distress; European Journal of Pediatrics, Supplement; (1996).

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  • Liquid ventilation: a comprehensive overview.; Neonatal network : NN; (1996).

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  • Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome; New England Journal of Medicine; (1996).

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  • Pulmonary administration of vasoactive substances by perfluorochemical ventilation; Pediatrics; (1996).

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  • Quantitative structure-activity relationships of perfluorinated hetero- hydrocarbons as potential respiratory media: Application to oxygen solubility, partition coefficient, viscosity, vapor pressure, and density; ASAIO Journal; (1996).

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  • Combined gas ventilation and perfluorochemical tracheal instillation as an alternative treatment for lethal congenital diaphragmatic hernia in lambs; Journal of Pediatric Surgery; (1995).

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  • Liquid ventilation improves pulmonary function, gas exchange, and lung injury in a model of respiratory failure; Annals of Surgery; (1995).

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  • Development and application of a simplified liquid ventilator; Critical Care Medicine; (1995).

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  • Use of liquid ventilation with perflubron during extracorporeal membrane oxygenation: Chest radiographic appearances; Radiology; (1995).

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  • Lung management with perfluorocarbon liquid ventilation improves pulmonary function and gas exchange during extracorporeal membrane oxygenation (ECMO); Artificial Cells, Blood Substitutes, and Biotechnology; (1994).

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  • Mathematical modeling of perfluorocarbon chemical (PFC) bio-distribution during liquid ventilation of lambs; Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; (1994).

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  • Neonatal endotracheal tubes: Variation in airway resistance with different perfluorochemical liquids; Artificial Cells, Blood Substitutes, and Biotechnology; (1994).

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  • Perfluorochemical liquid as a respiratory medium; Artificial Cells, Blood Substitutes, and Biotechnology; (1994).

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  • Utility of a perfluorochemical liquid for pulmonary diagnostic imaging; Artificial Cells, Blood Substitutes, and Biotechnology; (1994).

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  • Operative creation of left to right cardiac shunts: Pulmonary functional sequelae; The Annals of Thoracic Surgery; (1993).

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  • Inadvertent administration of positive end-distending pressure during nasal cannula flow; Pediatrics; (1993).

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  • Oxygen consumption and carbon dioxide production during liquid ventilation; Journal of Pediatric Surgery; (1993).

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  • Epithelial modulation of preterm airway smooth muscle contraction; Journal of Applied Physiology; (1993).

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  • High-resolution computed tomographic bronchiolography using perfluoroctylbromide (PFOB): An experimental model; Journal of Thoracic Imaging; (1993).

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  • Effect of exchange transfusion with a red blood cell substitute on neonatal hemodynamics and organ blood flows; Journal of Pediatric Surgery; (1993).

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  • Lung lavage with oxygenated perfluorochemical liquid in acute lung injury; Critical Care Medicine; (1993).

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  • Caffeine potentiates airway responsiveness in the neonatal lamb; Pediatric Pulmonology; (1992).

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  • Effects of inspiratory resistive loading on chest wall motion and ventilation: Differences between preterm and full-term infants; Pediatric Research; (1992).

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  • Effect of position on the mechanical interaction between the rib cage and abdomen in preterm infants; Journal of Applied Physiology; (1992).

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  • Comparison of gas and liquid ventilation: Clinical, physiological, and histological correlates; Journal of Applied Physiology; (1992).

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  • Maturational changes in airway smooth muscle structure-function relationships; Pediatric Research; (1992).

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  • Increased respiratory drive and limited adaptation to loaded breathing in bronchopulmonary dysplasia; Pediatric Research; (1992).

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  • Liquid ventilation.; Pediatric pulmonology; (1992).

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  • Structure-function of airway generations 0 to 4 in the preterm lamb; Pediatric Research; (1992).

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  • Structural deformation of the preterm trachea during acute distention and collapse.; Journal of developmental physiology; (1991).

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  • Airway responsiveness to low inspired gas temperature in preterm neonates; The Journal of Pediatrics; (1991).

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  • Developmental changes in tracheal structure; Pediatric Research; (1991).

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  • Dissociation between the effects of theophylline and caffeine on premature airway smooth muscle; Pediatric Research; (1991).

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  • Effect of nasal CPAP on thoracoabdominal motion in neonates with respiratory insufficiency; Pediatric Pulmonology; (1991).

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  • Immediate improvement in lung volume after exogenous surfactant: Alveolar recruitment versus increased distention; The Journal of Pediatrics; (1991).

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  • Interaction between chest wall motion and lung mechanics in normal infants and infants with bronchopulmonary dysplasia; Pediatric Pulmonology; (1991).

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  • Reply; The Journal of Pediatrics; (1991).

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  • Use of a touch sensitive screen and computer assisted image analysis for quantitation of developmental changes in pulmonary structure; Pediatric Pulmonology; (1990).

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  • Differential effects of pancuronium bromide on cardiopulmonary function in the neonatal lamb; Pediatric Pulmonology; (1990).

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  • Emergence of the brain-stem auditory evoked potential in the premature lamb; Electroencephalography and Clinical Neurophysiology; (1990).

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  • Liquid ventilation during early development: Theory, physiologic processes and application; Journal of Developmental Physiology; (1990).

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  • Liquid ventilation of human preterm neonates; The Journal of Pediatrics; (1990).

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  • Neonatal gastric intubation: Differential respiratory effects between nasogastric and orogastric tubes; Pediatric Pulmonology; (1990).

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  • Pericardial effects on diastolic ventricular interaction during development; Pediatric Research; (1990).

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  • Theoretical model of ventricular interdependence: Pericardial effects; American Journal of Physiology - Heart and Circulatory Physiology; (1990).

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  • Thoracoabdominal asynchrony in infants with airflow obstruction; American Review of Respiratory Disease; (1990).

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  • Effects of intravenous perfluorocarbon and oxygen breathing on acute decompression sickness in the hamster; Undersea Biomedical Research; (1989).

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  • In vivo mechanical properties of the developing airway; Pediatric Research; (1989).

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  • LIQUID VENTILATION OF PRETERM BABY; The Lancet; (1989).

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  • Mechanics and energetics of breathing in newly diagnosed infants with cystic fibrosis: Effect of combined bronchodilator and chest physical therapy; Pediatric Pulmonology; (1989).

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  • Structural changes in the tracheae of preterm lambs induced by ventilation; Pediatric Research; (1989).

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  • A comparison of preterm and adult airway smooth muscle mechanics; Journal of Applied Physiology; (1989).

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  • Developmental differences in tracheal cartilage mechanics; Pediatric Research; (1989).

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  • Effect of ventilation on mechanical properties and pressure-flow relationships of immature airways; Pediatric Research; (1988).

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  • A new experimental approach for the study of cardiopulmonary physiology during early development; Journal of Applied Physiology; (1988).

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  • Developmental changes in diastolic ventricular interaction; Pediatric Research; (1988).

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  • Effect of tracheal smooth muscle tone on collapsibility of immature airways; Journal of Applied Physiology; (1988).

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  • Evaluation of neonatal pulmonary mechanics and energetics: A two factor least mean square analysis; Pediatric Pulmonology; (1988).

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  • Fluorocarbon ventilation: Maximal expiratory flows and CO2 elimination; Pediatric Research; (1988).

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  • Influence of smooth muscle tone and longitudinal tension on the collapsibility of immature airways; Pediatric Pulmonology; (1988).

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  • Predictive changes in ventricular interdependence; Annals of Biomedical Engineering; (1988).

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  • A brief review: liquid ventilation.; Undersea Biomedical Research; (1987).

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  • A new approach to induced hypothermia; Journal of Surgical Research; (1986).

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  • A theoretical and experimental model of ventricular interdependence; Basic Research in Cardiology; (1986).

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  • The effect of tracheal smooth muscle tone on neonatal airway collapsibility; Pediatric Research; (1986).

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  • Pulmonary vascular resistance in the fluorocarbon-filled lung; Journal of Applied Physiology; (1986).

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  • Effect of high-frequency jet ventilation on preterm and rabbit tracheal mechanics; Pediatric Pulmonology; (1986).

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  • Acquired Tracheomegaly in Very Preterm Neonates; American Journal of Diseases of Children; (1986).

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  • The role of tracheal smooth muscle contraction on neonatal tracheal mechanics; Pediatric Research; (1986).

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  • A theoretical and experimental model of ventricular interdependence; Federation Proceedings; (1985).

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  • Developmental alterations in pulmonary function of the lamb; Respiration; (1985).

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  • In-vivo evaluation of interfacial surface tension on developmental lung mechanics; Federation Proceedings; (1985).

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  • Preterm infants: Ventilation and P100 changes with CO2 and inspiratory resistive loading; Journal of Applied Physiology; (1985).

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  • Gallbladder mechanics in newborn piglets; Pediatric Research; (1984).

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  • A fine structure study of the liquid-ventilated newborn rabbit lung; Federation Proceedings; (1984).

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  • Effect of external inspiratory loading on ventilation of premature infants; Pediatric Research; (1984).

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  • Liquid ventilation: Effects on pulmonary function in distressed meconium-stained lambs; Pediatric Research; (1984).

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  • Mechanics and energetics of breathing helium in infants with bronchopulmonary dysplasia; The Journal of Pediatrics; (1984).

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  • Physiological effects of ventilation with liquid fluorocarbon at controlled temperatures; Undersea Biomedical Research; (1984).

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  • Tracheal volume deformation in a developmental rabbit model; Neonatology; (1984).

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  • Cardiopulmonary function in very preterm lambs during liquid ventilation; Pediatric Research; (1983).

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  • Decompression incidence in air- and liquid-breathing hamsters; Undersea Biomedical Research; (1983).

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  • Effect of liquid ventilation on preterm lamb tracheal mechanics; Biology of the Neonate; (1983).

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  • The effects of liquid ventilation on cardiopulmonary function in preterm lambs.; Pediatric research; (1983).

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  • Effect of low-rate intermittent mandatory ventilation on pulmonary function of low-birth-weight infants; The Journal of Pediatrics; (1982).

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  • Respiratory muscle function, assessment, and training; Physical Therapy; (1982).

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  • Time-dependent tracheal deformation in fetal, neonatal, and adult rabbits; Pediatric Research; (1982).

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  • Effect of intermittent positive pressure application on the bulk modulus of the developing rabbit trachea; Respiration; (1981).

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  • Increased pulmonary vascular resistance during liquid ventilation; Undersea Biomedical Research; (1981).

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  • Instrumentation for measuring cardiac output by direct Fick method during liquid ventilation; Undersea Biomedical Research; (1981).

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  • Pressure-induced deformation in immature airways; Pediatric Research; (1981).

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  • Pressure-volume relationships of tracheae in fetal newborn and adult rabbits; Respiration Physiology; (1981).

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  • Successful extubation of neonates: clinical and physiological factors.; Critical care medicine; (1981).

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  • Use of external expiratory resistance in intubated neonates to increase lung volume; Archives of Disease in Childhood; (1981).

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  • Alterations in bulk modulus of tracheae during development; Respiration; (1980).

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  • Clinical assessment of pulmonary function in the neonate; Clinics in Chest Medicine; (1980).

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  • SMALL VOLUME PLETHYSMOGRAPHIC RECORDINGS USING A CAPACITIVE TRANSDUCER.; Multi-phase Transport: Fundamentals, Reactor Safety, Applications; (1980).

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  • Sequential effects of acute meconium obstruction on pulmonary function; Pediatric Research; (1980).

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  • The effect of external expiratory resistance on lung volume and pulmonary function in the neonate; The Journal of Pediatrics; (1980).

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  • A new device for diagnosis and treatment of neonatal pneumothorax; Pediatrics; (1979).

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  • Cardiopulmonary changes in the crying neonate; Pediatric Research; (1979).

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  • Effects of endotracheal tube leaks on functional residual capacity determination in intubated neonates; Pediatric Research; (1979).

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  • Improved oxygenation and lung compliance withprone positioning of neonates; The Journal of Pediatrics; (1979).

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  • Liquid ventilation: Cardiovascular adjustments with secondary hyperlactatemia and acidosis; Journal of Applied Physiology Respiratory Environmental and Exercise Physiology; (1979).

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  • Low rate intermittent mandatory ventilation (IMV) in the neonate; Anesthesiology; (1979).

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  • A closed system device for diagnosis and evaluation of neonatal pneumothoraces.; Critical care medicine; (1978).

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  • A Method for Measuring Functional Residual Capacity in Neonates with Endotracheal Tubes; IEEE Transactions on Biomedical Engineering; (1978).

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  • Alterations in pulmonary function of premature lambs due to positive end-expiratory pressure; Respiration; (1978).

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  • Error Analysis for Vector Scope Measurement of Pulmonary Mechanics; IEEE Transactions on Biomedical Engineering; (1978).

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  • Positive end expiratory pressure: Effects on lung mechanics of premature lambs; Biology of the Neonate; (1978).

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  • Pulmonary lavage in preterm lambs; Pediatric Research; (1978).

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  • Pulmonary physiotherapy in neonates: Physiologic changes and respiratory management; The Journal of Pediatrics; (1978).

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  • Effect of positive end expiratory pressure on lung mechanics of premature lambs; Federation Proceedings; (1977).

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  • Instrumentation for measuring functional residual capacity in small animals; Journal of Applied Physiology Respiratory Environmental and Exercise Physiology; (1977).

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  • The Interaction of FRC and Ventilation on Occlusion Pressure in Conscious Man; IEEE Transactions on Biomedical Engineering; (1977).

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  • Tracheal extubation of the neonate at 2 to 3 cm H2O continuous positive airway pressure; Pediatrics; (1977).

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  • Gaseous exchange and acid-base balance in premature lambs during liquid ventilation since birth; Pediatric Research; (1976).

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  • Pulmonary function in premature lambs during the first few hours of life; Respiration Physiology; (1976).

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  • An Electromechanical Demand Regulated Liquid Breathing System; IEEE Transactions on Biomedical Engineering; (1975).

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  • Limitations of Frequency Dependence as a Measure of Airway Obstruction; IEEE Transactions on Biomedical Engineering; (1975).

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  • Liquid breathing trials and animal studies with a demand regulated liquid breathing system; Medical Instrumentation; (1975).

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  • Demand controlled liquid ventilation of the lungs; Journal of Applied Physiology; (1974).

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