Scott L. Weiss, MD

Chief Critical Care

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Fellowship

  • Pediatric Critical Care Med - McGaw Medical Center of Northwestern University, 2011

Internship Residency

  • General Pediatrics - Boston Childrens Hospital/Boston Medical Center, 2007

Medical/Dental School

  • Bachelor of Science Cornell University
  • MD - Harvard Medical School, 2004

Board Certifications

  • American Board of Pediatrics/Critical Care
  • American Board of Pediatrics/General Pediatrics

  • Is hyperchloremia following sepsis resuscitation with 0.9% saline clin-ically important?; Critical Care and Shock; (2021).

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  • Implementation of a Follow-Up System for Pediatric Sepsis Survivors in a Large Academic Pediatric Intensive Care Unit; Frontiers in Pediatrics; (2021).

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  • Impaired lymphocyte responses in pediatric sepsis vary by pathogen type; medRxiv; (2021).

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  • Association of early hypotension in pediatric sepsis with development of new or persistent acute kidney injury; Pediatric Nephrology; (2021).

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  • A Wrinkle in Time to Antibiotics in Sepsis: When Should ONE Hour Be the Goal?; Journal of Pediatrics; (2021).

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  • A Stitch in Time: Optimizing Antibiotic Use From the Start; Critical care medicine; (2021).

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  • What's the Cost? Measuring the Economic Impact of Pediatric Sepsis; Frontiers in Pediatrics; (2021).

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  • Recalibration of the Renal Angina Index for Pediatric Septic Shock; Kidney International Reports; (2021).

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  • PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial; Trials; (2021).

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  • Let Us Not Forget Early Mortality in Pediatric Sepsis; Pediatric Critical Care Medicine; (2021).

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  • Left Ventricular Diastolic Dysfunction in Pediatric Sepsis: Outcomes in a Single-Center Retrospective Cohort Study; Pediatric Critical Care Medicine; (2021).

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  • Integrating Focused Cardiac Ultrasound into Pediatric Septic Shock Assessment; Pediatric Critical Care Medicine; (2021).

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  • Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children; Pediatric Critical Care Medicine; (2020).

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  • The authors reply; Pediatric Critical Care Medicine; (2020).

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  • The authors reply; Pediatric Critical Care Medicine; (2020).

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  • The authors reply; Pediatric Critical Care Medicine; (2020).

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  • The authors reply; Pediatric Critical Care Medicine; (2020).

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  • Utility of Procalcitonin as a Biomarker for Sepsis in Children; Journal of Clinical Microbiology; (2020).

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  • Severe acute kidney injury is independently associated with mortality in children with septic shock; Intensive Care Medicine; (2020).

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  • Clinical Signs to Categorize Shock and Target Vasoactive Medications in Warm Versus Cold Pediatric Septic Shock; Pediatric Critical Care Medicine; (2020).

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  • Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children; Blood Advances; (2020).

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  • Diaphragm atrophy during pediatric acute respiratory failure is associated with prolonged noninvasive ventilation requirement following extubation; Pediatric Critical Care Medicine; (2020).

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  • Executive summary: Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children; Pediatric Critical Care Medicine; (2020).

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  • Risk of Mortality in Immunocompromised Children with Severe Sepsis and Septic Shock; Critical Care Medicine; (2020).

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  • Reactivation viremia in pediatric sepsis; Pediatric Critical Care Medicine; (2020).

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  • RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness; Journal of Allergy and Clinical Immunology; (2020).

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  • Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4 (Nature, (2020), 587, 7834, (466-471), 10.1038/s41586-020-2877-5); Nature; (2020).

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  • Proprotein convertase subtilisin/kexin type 9 loss-of-function is detrimental to the juvenile host with septic shock; Critical Care Medicine; (2020).

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  • Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019; Pediatric Critical Care Medicine; (2020).

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  • PERSEVERE Biomarkers predict severe acute kidney injury and renal recovery in pediatric septic shock; American Journal of Respiratory and Critical Care Medicine; (2020).

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  • Mitochondrial Dysfunction is Associated With an Immune Paralysis Phenotype in Pediatric Sepsis; Shock (Augusta, Ga.); (2020).

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  • Might the surviving sepsis campaign international guidelines be less confusing? Authors' reply; Intensive Care Medicine; (2020).

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  • Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated with a Lower Occurrence of Adverse Hemodynamic Events; Critical Care Medicine; (2020).

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  • Identification of pediatric sepsis for epidemiologic surveillance using electronic clinical data; Pediatric Critical Care Medicine; (2020).

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  • Exuberant fibroblast activity compromises lung function via ADAMTS4; Nature; (2020).

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  • Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children; Intensive Care Medicine; (2020).

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  • Surviving Sepsis in a Referral Neonatal Intensive Care Unit: Association between Time to Antibiotic Administration and In-Hospital Outcomes; Journal of Pediatrics; (2020).

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  • Systemic endothelial activation is associated with early acute respiratory distress syndrome in children with extrapulmonary sepsis; Critical Care Medicine; (2020).

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  • Clinical Update in Pediatric Sepsis: Focus on Children With Pre-Existing Heart Disease; Journal of Cardiothoracic and Vascular Anesthesia; (2020).

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  • Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children; Intensive Care Medicine; (2020).

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  • Association between elevated RBC distribution width and multiple organ dysfunction in pediatric critical illness; Pediatric Critical Care Medicine; (2020).

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  • Vancomycin monotherapy may be insufficient to treat methicillin-resistant staphylococcus aureus coinfection in children with influenza-related critical illness; Clinical Infectious Diseases; (2019).

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  • Risks and benefits of fluid bolus therapy: The need for a good explanation; Archives of Disease in Childhood; (2019).

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  • Evaluation of mannose binding lectin gene variants in pediatric influenza virus-related critical illness; Frontiers in Immunology; (2019).

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  • Neonatal sepsis registry: Time to antibiotic dataset; Data in Brief; (2019).

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  • Matched Retrospective Cohort Study of Thiamine to Treat Persistent Hyperlactatemia in Pediatric Septic Shock; Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies; (2019).

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  • Major adverse kidney events in pediatric sepsis; Clinical Journal of the American Society of Nephrology; (2019).

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  • Is chloride worth its salt?; Intensive Care Medicine; (2019).

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  • Implementation of a Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study; Journal of the Pediatric Infectious Diseases Society; (2019).

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  • Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database; Critical care medicine; (2019).

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  • A national approach to pediatric sepsis surveillance; Pediatrics; (2019).

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  • Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: The PRoMPT BOLUS Randomized Controlled Trial Pilot Feasibility Study; Academic Emergency Medicine; (2019).

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  • Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis; Critical care medicine; (2019).

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  • Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis; Journal of Surgical Research; (2019).

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  • Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model; Science Translational Medicine; (2019).

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  • Reducing Collateral Damage from Mandates for Time to Antibiotics in Pediatric Sepsis - Primum Non Nocere; JAMA Pediatrics; (2019).

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  • Risk factors and inpatient outcomes associated with acute kidney injury at pediatric severe sepsis presentation; Pediatric Nephrology; (2018).

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  • Progressive diaphragm atrophy in pediatric acute respiratory failure; Pediatric Critical Care Medicine; (2018).

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  • Measuring hospital performance in pediatric sepsis: Without reliable risk there is no reward; Pediatric Critical Care Medicine; (2018).

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  • Hypofibrinogenemia is associated with poor outcome and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome in pediatric severe sepsis; Pediatric Critical Care Medicine; (2018).

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  • Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock; Intensive Care Medicine; (2018).

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  • Hyperchloremia Is Associated with Complicated Course and Mortality in Pediatric Patients with Septic Shock; Pediatric Critical Care Medicine; (2018).

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  • Focus on paediatrics: 2017; Intensive Care Medicine; (2018).

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  • Endotype Transitions During the Acute Phase of Pediatric Septic Shock Reflect Changing Risk and Treatment Response; Critical care medicine; (2018).

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  • Effect of the procalcitonin assay on antibiotic use in critically ill children; Journal of the Pediatric Infectious Diseases Society; (2018).

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  • Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis; JAMA - Journal of the American Medical Association; (2018).

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  • Are septic children really just "septic little adults"?; Intensive Care Medicine; (2018).

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  • Taking meaning from numbers in regional epidemiological data; The Lancet Child and Adolescent Health; (2018).

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  • Site variability in regulatory oversight for an international study of pediatric sepsis; Pediatric Critical Care Medicine; (2018).

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  • The Failing Myocardium in Sepsis; Heart Failure in the Child and Young Adult: From Bench to Bedside; (2018).

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  • The association of nutrition status expressed as body mass index z score with outcomes in children with severe sepsis: A secondary analysis from the sepsis prevalence, outcomes, and therapies (SPROUT) study; Critical Care Medicine; (2018).

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  • Response to letter to the editor: Sepsis-associated in-hospital cardiac arrest; Journal of Critical Care; (2017).

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  • High Levels of Morbidity and Mortality among Pediatric Hematopoietic Cell Transplant Recipients with Severe Sepsis: Insights from the Sepsis PRevalence, OUtcomes, and Therapies International Point Prevalence Study; Pediatric Critical Care Medicine; (2017).

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  • The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary; Pediatric Critical Care Medicine; (2017).

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  • The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children with Sepsis Die; Pediatric Critical Care Medicine; (2017).

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  • Glucocorticoid Receptor Polymorphisms and Outcomes in Pediatric Septic Shock; Pediatric Critical Care Medicine; (2017).

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  • Recommendations for regulation of screen viewing times in childhood and adolescence: Consensus paper of the working group on sleep medicine and sleep research of the Austrian Society of Pediatrics and Adolescent Medicine,Empfehlungen zur Regulierung von Bildschirmzeiten im Kindes- und Jugendalter: Konsensuspapier der Arbeitsgruppe Schlafmedizin und Schlafforschung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde; Monatsschrift fur Kinderheilkunde; (2017).

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  • Pathophysiology of pediatric multiple organ dysfunction syndrome; Pediatric Critical Care Medicine; (2017).

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  • New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality; Pediatric Critical Care Medicine; (2017).

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  • Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure; Pediatric Critical Care Medicine; (2017).

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  • Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign-Based Electronic Alert and Bedside Clinician Identification; Annals of Emergency Medicine; (2017).

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  • Improved risk stratification in pediatric septic shock using both protein and mRNA Biomarkers: Persevere-XP; American Journal of Respiratory and Critical Care Medicine; (2017).

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  • Cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukemia; Critical Care Medicine; (2017).

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  • Sepsis-associated in-hospital cardiac arrest: Epidemiology, pathophysiology, and potential therapies; Journal of Critical Care; (2017).

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  • Crystalloid Fluid Choice and Clinical Outcomes in Pediatric Sepsis: A Matched Retrospective Cohort Study; Journal of Pediatrics; (2017).

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  • Clinical Trials in Pediatric Sepsis: What's the (End) Point?; Pediatric Critical Care Medicine; (2017).

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  • Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis; Shock; (2017).

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  • American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock; Critical Care Medicine; (2017).

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  • A pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: The optimizing antibiotic strategies in sepsis (OASIS) study; Journal of the Pediatric Infectious Diseases Society; (2017).

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  • The authors reply; Pediatric Critical Care Medicine; (2017).

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  • Combining Prognostic and Predictive Enrichment Strategies to Identify Children with Septic Shock Responsive to Corticosteroids; Critical Care Medicine; (2016).

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  • Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs; Pediatric Critical Care Medicine; (2016).

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  • Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit; Journal of Pediatrics; (2016).

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  • Protocolized Treatment Is Associated with Decreased Organ Dysfunction in Pediatric Severe Sepsis; Pediatric Critical Care Medicine; (2016).

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  • Pediatric severe sepsis/septic shock associated with healthcare-associated infections; Infection Control and Hospital Epidemiology; (2016).

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  • Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model with Septic Shock Phenotype; Critical Care Medicine; (2016).

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  • Staphylococcus aureus a-toxin response distinguishes respiratory virus-methicillin-resistant s. aureus coinfection in children; Journal of Infectious Diseases; (2016).

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  • Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia; Cancer Discovery; (2016).

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  • Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells; Clinical Toxicology; (2016).

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  • Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid- Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein; PLoS ONE; (2016).

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  • Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability; Critical Care Medicine; (2016).

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  • 2016 Update for the Rogers' Textbook of Pediatric Intensive Care: Recognition and Initial Management of Shock; Pediatric Critical Care Medicine; (2016).

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  • Hyperferritinemic sepsis: An opportunity for earlier diagnosis and intervention?; Frontiers in Pediatrics; (2016).

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  • Prospective Testing and Redesign of a Temporal Biomarker Based Risk Model for Patients With Septic Shock: Implications for Septic Shock Biology; EBioMedicine; (2015).

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  • The authors reply; Pediatric Critical Care Medicine; (2015).

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  • Red blood cell distribution width as a pragmatic marker for outcome in pediatric critical illness; PLoS ONE; (2015).

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  • Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock; Pediatric Critical Care Medicine; (2015).

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  • Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department; Academic Emergency Medicine; (2015).

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  • Long-Term Respiratory Support for Children and Adolescents in Austria: A National Survey; Klinische Padiatrie; (2015).

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  • Initial resuscitation and management of pediatric septic shock; Minerva pediatrica; (2015).

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  • Identifying Pediatric Severe Sepsis and Septic Shock: Accuracy of Diagnosis Codes; The Journal of pediatrics; (2015).

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  • Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study; American journal of respiratory and critical care medicine; (2015).

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  • Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study; Critical Care; (2015).

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  • Differential expression of the Nrf2-linked genes in pediatric septic shock; Critical Care; (2015).

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  • A multibiomarker-based model for estimating the risk of septic acute kidney injury; Critical Care Medicine; (2015).

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  • Developing a clinically feasible personalized medicine approach to pediatric septic shock; American Journal of Respiratory and Critical Care Medicine; (2015).

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  • Understanding the global epidemiology of pediatric critical illness: The power, pitfalls, and practicalities of point prevalence studies; Pediatric Critical Care Medicine; (2014).

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  • The temporal version of the pediatric sepsis biomarker risk model; PLoS ONE; (2014).

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  • Elevated malondialdehyde levels in sepsis - something to 'stress' about?; Critical Care; (2014).

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  • Pediatric severe sepsis in U.S. children's hospitals; Pediatric Critical Care Medicine; (2014).

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  • Post-ICU admission fluid balance and pediatric septic shock outcomes: A risk-stratified analysis; Critical Care Medicine; (2014).

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  • Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model; PLoS ONE; (2014).

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  • Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock; Critical Care; (2014).

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  • Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis; Critical Care Medicine; (2014).

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  • Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock; American Journal of Respiratory and Critical Care Medicine; (2014).

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  • Corticosteroids and pediatric septic shock outcomes: A risk stratified analysis; PLoS ONE; (2014).

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  • Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation?; Shock; (2013).

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  • Pilot study of the association of the DDAH2-449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis; PLoS ONE; (2012).

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  • Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis; Pediatric Critical Care Medicine; (2012).

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  • Defining pediatric sepsis by different criteria: Discrepancies in populations and implications for clinical practice; Pediatric Critical Care Medicine; (2012).

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  • Diagnosis of a craniopharyngioma after acute brainstem herniation in an emergency department; Pediatric Emergency Care; (2011).

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  • Comparison of gastrointestinal morbidity after Norwood and hybrid palliation for complex heart defects; Pediatric Cardiology; (2011).

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  • Calcified Right Atrial Myxoma in an Adolescent; World Journal for Pediatric and Congenital Heart Surgery; (2011).

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  • Extreme stress hyperglycemia during acute illness in a pediatric emergency department; Pediatric Emergency Care; (2010).

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  • Procalcitonin levels in febrile infants after recent immunization; Pediatrics; (2008).

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  • Procalcitonin in young febrile infants for the detection of Serious bacterial infections; Pediatrics; (2008).

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  • Robust coupling of body movement and gaze in young infants; Developmental Psychobiology; (2007).

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