Subir Kumar Roy Chowdhury, PhD

Assistant Research Scientist

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Education

  • MD - Charles University, First Faculty of Medicine, 1997
  • PhD - Charles University, Bioenergetics, 2002

  • Mitochondria Profoundly Influence Apolipoprotein E Biology.; Journal of Alzheimer's disease : JAD; (2023).

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  • Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma.; Nature communications; (2023).

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  • Ex Vivo Mitochondrial Respiration Parallels Biochemical Response to Ibrutinib in CLL Cells.; Cancers; (2021).

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  • Muscarinic Toxin 7 Signals Via Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration.; Molecular neurobiology; (2020).

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  • Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer's Mice.; Cells; (2020).

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  • Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease.; Nutrients; (2020).

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  • Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment.; Cancers; (2020).

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  • Activation of Cannabinoid Receptors Attenuates Endothelin-1-Induced Mitochondrial Dysfunction in Rat Ventricular Myocytes.; Journal of cardiovascular pharmacology; (2020).

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  • Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons.; Neuropharmacology; (2019).

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  • High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.; Experimental neurology; (2018).

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  • Chronic dietary creatine enhances hippocampal-dependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB.; Learning & memory (Cold Spring Harbor, N.Y.); (2018).

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  • Targeting Mitochondrial Bioenergetics as a Therapeutic Strategy for Chronic Lymphocytic Leukemia.; Oxidative medicine and cellular longevity; (2018).

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  • Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior.; Stem cell research & therapy; (2018).

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  • Depressed mitochondrial function and electron transport Complex II-mediated H<sub>2</sub>O<sub>2</sub> production in the cortex of type 1 diabetic rodents.; Molecular and cellular neurosciences; (2018).

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  • Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.; Experimental neurology; (2017).

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  • Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease.; Neuroscience; (2017).

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  • Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs.; Intensive care medicine experimental; (2016).

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  • Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria.; Bioscience reports; (2015).

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  • The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats.; Experimental neurology; (2015).

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  • Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.; Proceedings of the National Academy of Sciences of the United States of America; (2014).

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  • Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents.; Cellular and molecular neurobiology; (2014).

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  • Mitochondrial dysfunction in rabies virus infection of neurons.; Journal of neurovirology; (2013).

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  • Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.; Molecular brain; (2013).

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  • The role of aberrant mitochondrial bioenergetics in diabetic neuropathy.; Neurobiology of disease; (2012).

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  • Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents.; Neuropharmacology; (2012).

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  • Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes.; Brain : a journal of neurology; (2012).

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  • Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes.; Mitochondrion; (2011).

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  • Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cells.; Acta biochimica Polonica; (2010).

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  • Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.; Diabetes; (2010).

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  • Mitochondrial stress and the pathogenesis of diabetic neuropathy.; Expert review of endocrinology & metabolism; (2010).

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  • Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment.; Diabetes; (2010).

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  • 4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy.; Neurotoxicity research; (2009).

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  • Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells.; American journal of physiology. Endocrinology and metabolism; (2009).

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  • Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated low-density lipoprotein.; Free radical biology & medicine; (2009).

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  • Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.; Free radical research; (2007).

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  • High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines.; Biochemical and biophysical research communications; (2005).

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  • Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome.; Biochimica et biophysica acta; (2003).

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  • Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide.; Journal of bioenergetics and biomembranes; (2002).

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  • A novel mutation in SURF1 causes skipping of exon 8 in a patient with cytochrome c oxidase-deficient leigh syndrome and hypertrichosis.; Molecular genetics and metabolism; (2001).

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  • Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes.; Clinica chimica acta; international journal of clinical chemistry; (2000).

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  • A novel deficiency of mitochondrial ATPase of nuclear origin.; Human molecular genetics; (1999).

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