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- Sonali P. Barwe, PhD
Sonali P. Barwe, PhD
Senior Research Scientist
Nemours Children's Hospital, Delaware
1600 Rockland Road
Wilmington,
DE
19803
Biography
Dr. Barwe received her Ph.D. in Biochemistry from The Indian Institute of Science in 2000. From 2000 to 2007, she worked as a Postdoc Researcher at the University of California, Los Angeles conducting research on the role of Na,K-ATPase as a cell adhesion molecule. In 2007, she became an Assistant Research Scientist at the Alfred I. duPont Hospital for Children, where she began developing leukemia xenograft mouse models using samples from patients treated at Nemours. Dr. Barwe currently heads the Preclinical Leukemia Testing Laboratory within the Nemours Center for Childhood Cancer Research. Dr. Barwe's primary research interests are to study the role of calcium binding proteins in childhood leukemia, and understanding the molecular mechanisms of drug resistance and relapse with a goal of identifying novel therapeutic targets or drug combinations.
Education & Training
Medical/Dental School
- BS - University of Mumbai, Botany, 1995
- MS - University of Mumbai, Genetics, 1997
- PhD - Indian Institute of Science, Biochemistry, 2000
- Postdoc - UCLA, Tumor Biology, 2001-2007
- Biochemistry
- Biotechnology
- Cell Biology
- Genomics/Metabolomics/Proteomics
- Molecular Biology
- Oncology
- Physiology
- Barwe, S. P., Kisielewski, A., Bonvini, E., Muth, J., Davidson-Moncada, J., Kolb, E. A., & Gopalakrishnapillai, A. (2022). Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia. Journal of Clinical Medicine, 11(5). doi:10.3390/jcm11051333
- Heikamp, E. B., Henrich, J. A., Perner, F., Wong, E. M., Hatton, C., Wen, Y., & Armstrong, S. A. (2022). The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood, 139(6), 894-906. doi:10.1182/blood.2021012806
View Full Publication - Barwe, S. P., Sebastian, A., Sidhu, I., Kolb, E. A., & Gopalakrishnapillai, A. (2022). Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21. Cells, 11(4). doi:10.3390/cells11040628
View Full Publication - Gopalakrishnapillai, A., Correnti, C. E., Pilat, K., Lin, I., Chan, M. K., Bandaranayake, A. D., & Barwe, S. P. (2021). Immunotherapeutic targeting of mesothelin positive pediatric aml using bispecific t cell engaging antibodies. Cancers, 13(23). doi:10.3390/cancers13235964
- Sidhu, I., Barwe, S. P., Pillai, R. K., & Gopalakrishnapillai, A. (2021). Harnessing the power of induced pluripotent stem cells and gene editing technology: Therapeutic implications in hematological malignancies. Cells, 10(10). doi:10.3390/cells10102698
View Full Publication - Sidhu, I., Barwe, S. P., Kiick, K. L., Kolb, E. A., & Gopalakrishnapillai, A. (2021). A 3-D hydrogel based system for hematopoietic differentiation and its use in modeling down syndrome associated transient myeloproliferative disorder. Biomaterials Science, 9(18), 6266-6281. doi:10.1039/d1bm00442e
View Full Publication - Sidhu, I., Barwe, S. P., & Gopalakrishnapillai, A. (2021). The extracellular matrix: A key player in the pathogenesis of hematologic malignancies. Blood Reviews, 48. doi:10.1016/j.blre.2020.100787
View Full Publication - Kaeding, A. J., Barwe, S. P., Gopalakrishnapillai, A., Ries, R. E., Alonzo, T. A., Gerbing, R. B., & Meshinchi, S. (2021). Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia. Blood Advances, 5(9), 2350-2361. doi:10.1182/BLOODADVANCES.2021004424
View Full Publication - Barwe, S. P., Sidhu, I., Kolb, E. A., & Gopalakrishnapillai, A. (2020). Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology. Molecular Therapy - Methods and Clinical Development, 19, 201-209. doi:10.1016/j.omtm.2020.09.007
- Quagliano, A., Gopalakrishnapillai, A., Anders Kolb, E., & Barwe, S. P. (2020). CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia. Blood Advances, 4(18), 4393-4405. doi:10.1182/BLOODADVANCES.2020001592
View Full Publication - Quagliano, A., Gopalakrishnapillai, A., & Barwe, S. P. (2020). Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer. Frontiers in Oncology, 10. doi:10.3389/fonc.2020.00992
- Crowgey, E. L., Mahajan, N., Wong, W. H., Gopalakrishnapillai, A., Barwe, S. P., Kolb, E. A., & Druley, T. E. (2020). Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring. BMC Medical Genomics, 13(1). doi:10.1186/s12920-020-0671-8
View Full Publication - Barwe, S. P., Gopalakrisnapillai, A., Mahajan, N., Druley, T. E., Kolb, E. A., & Crowgey, E. L. (2020). Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples. Genomics and Informatics, 18(1). doi:10.5808/GI.2020.18.1.e6
- Balasubramaniam, S. L., Gopalakrishnapillai, A., Petrelli, N. J., & Barwe, S. P. (2017). Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Journal of Biological Chemistry, 292(27), 11388-11399. doi:10.1074/jbc.M116.752352
View Full Publication - Gopalakrishnapillai, A., Kolb, E. A., McCahan, S. M., & Barwe, S. P. (2017). Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia. Leukemia Research, 58, 91-97. doi:10.1016/j.leukres.2017.05.004
View Full Publication - Quagliano, A., Gopalakrishnapillai, A., & Barwe, S. P. (2017). Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. Leukemia Research, 56, 36-43. doi:10.1016/j.leukres.2017.01.030
View Full Publication - Barwe, S. P., Quagliano, A., & Gopalakrishnapillai, A. (2017). Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. Seminars in Oncology, 44(2), 101-112. doi:10.1053/j.seminoncol.2017.06.005
View Full Publication - Gopalakrishnapillai, A., Kolb, E. A., Dhanan, P., Bojja, A. S., Mason, R. W., Corao, D., & Barwe, S. P. (2016). Generation of pediatric leukemia xenograft models in NSG-B2m mice: Comparison with NOD/SCID mice. Frontiers in Oncology, 6(JUN). doi:10.3389/fonc.2016.00162
- Huynh, T. P., Barwe, S. P., Lee, S. J., McSpadden, R., Franco, O. E., Hayward, S. W., & Rajasekaran, A. K. (2015). Glucocorticoids suppress renal cell carcinoma progression by enhancing Na, K-ATPase beta-1 subunit expression. PLoS ONE, 10(4). doi:10.1371/journal.pone.0122442
View Full Publication - Balasubramaniam, S. L., Gopalakrishnapillai, A., Gangadharan, V., Duncan, R. L., & Barwe, S. P. (2015). Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling. Journal of Biological Chemistry, 290(20), 12463-12473. doi:10.1074/jbc.M114.629519
View Full Publication - Lee, S. J., Litan, A., Li, Z., Graves, B., Lindsey, S., Barwe, S. P., & Langhans, S. A. (2015). Na,K-ATPase B1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Molecular Cancer, 14(1). doi:10.1186/s12943-015-0430-1
View Full Publication - Balasubramaniam, S. L., Gopalakrishnapillai, A., & Barwe, S. P. (2015). Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration. American Journal of Physiology - Cell Physiology, 309(6), C437-C441. doi:10.1152/ajpcell.00140.2015
View Full Publication - Gopalakrishnapillai, A., Kolb, E. A., Dhanan, P., Mason, R. W., Napper, A., & Barwe, S. P. (2015). Disruption of Annexin II /p11 interaction suppresses leukemia cell binding, homing and engraftment, and sensitizes the leukemia cells to chemotherapy. PLoS ONE, 10(10). doi:10.1371/journal.pone.0140564
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