Sonali P Barwe

Sr Research Scientist

Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Dr. Barwe is a Senior Research Scientist heading the Cancer Modeling Laboratory at Nemours. After completing her Postdoc at UCLA, she joined Nemours in 2007. Her research is focused on deciphering the role of the bone marrow microenvironment in therapy resistance and identifying means to reverse it. Dr. Barwe works on developing patient-derived xenograft models of pediatric leukemia for preclinical drug evaluation with the goal of transitioning to the clinic. She also mentors UD graduate students and co-directs the Nemours Summer Undergraduate Research Program.

Medical/Dental School

  • MSc - University of Mumbai, 1997
  • PhD - Indian Institute of Science, Biochemistry, 2001

  • Chemosensitization
  • Epigenetic Drugs
  • Leukemia
  • Patient-Derived Xenografts

  • Bone Marrow Microenvironment-Induced Chemoprotection in KMT2A Rearranged Pediatric AML Is Overcome by Azacitidine-Panobinostat Combination; Cancers; (2023).

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  • Mesothelin: An Immunotherapeutic Target beyond Solid Tumors; Cancers; (2022).

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  • Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts; Journal of Clinical Medicine; (2022).

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  • Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia; Journal of Clinical Medicine; (2022).

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  • Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21; Cells; (2022).

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  • Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies; Cancers; (2021).

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  • Harnessing the Power of Induced Pluripotent Stem Cells and Gene Editing Technology: Therapeutic Implications in Hematological Malignancies; Cells; (2021).

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  • The extracellular matrix: A key player in the pathogenesis of hematologic malignancies.; Blood reviews; (2020).

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  • Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology.; Molecular therapy. Methods & clinical development; (2020).

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  • CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia.; Blood advances; (2020).

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  • Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples.; Genomics & informatics; (2020).

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  • Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer.; Frontiers in oncology; (2020).

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  • Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring.; BMC medical genomics; (2020).

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  • A Hydrogel Based 3D Culture System for Hematopoietic Differentiation of Induced Pluripotent Stem Cells; Blood; (2019).

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  • Abstract LB-322: Identification of a novel fusion protein SPTAN1-ABL1 in a child with T-cell acute lymphoblastic leukemia: Functional characterization and therapeutic implications; Tumor Biology; (2019).

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  • Mesothelin Targeting Bites for Pediatric AML: In Vivo Efficacy and Specificity; Blood; (2019).

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  • Effect of Ara-C on T-Cell Function and Flotetuzumab Activity in Pediatric Acute Myeloid Leukemia; Blood; (2019).

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  • Generation, Characterization and Pre-Clinical Drug Evaluation of Patient-Derived Xenograft Models of Pediatric Down Syndrome AML; Blood; (2019).

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  • In Vivo Evaluation of Mesothelin As a Therapeutic Target in Pediatric Acute Myeloid Leukemia; Blood; (2019).

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  • Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia.; Leukemia research; (2017).

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  • Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells.; The Journal of biological chemistry; (2017).

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  • Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.; Seminars in oncology; (2017).

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  • Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia.; Leukemia research; (2017).

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  • Generation of Pediatric Leukemia Xenograft Models in NSG-B2m Mice: Comparison with NOD/SCID Mice.; Frontiers in oncology; (2016).

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  • Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.; PloS one; (2015).

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  • Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration.; American journal of physiology. Cell physiology; (2015).

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  • Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.; Molecular cancer; (2015).

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  • Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.; PloS one; (2015).

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  • Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.; The Journal of biological chemistry; (2015).

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  • Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma.; Cancer medicine; (2014).

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  • Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity; Cancer & Metabolism; (2014).

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  • Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells.; Molecular cancer therapeutics; (2013).

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  • Regulation of Na,K-ATPase β1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells.; Experimental eye research; (2013).

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  • Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine.; Molecular pharmaceutics; (2012).

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  • Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells.; Journal of cell science; (2012).

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  • Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor.; Experimental cell research; (2011).

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  • Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.; Journal of molecular and cellular cardiology; (2009).

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  • Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin.; Cancer chemotherapy and pharmacology; (2009).

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  • alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.; Molecular cancer therapeutics; (2008).

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  • Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix.; International journal of oncology; (2007).

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  • Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2.; International journal of oncology; (2007).

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  • Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature.; Microvascular research; (2006).

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  • Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.; Cellular and molecular biology (Noisy-le-Grand, France); (2006).

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  • Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization.; Journal of molecular biology; (2006).

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  • Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells.; American journal of physiology. Gastrointestinal and liver physiology; (2006).

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  • Multiple functions of Na,K-ATPase in epithelial cells.; Seminars in nephrology; (2005).

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  • Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.; Molecular biology of the cell; (2004).

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  • HLA class I signal transduction is dependent on Rho GTPase and ROK.; Biochemical and biophysical research communications; (2004).

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  • The requirements for Ca2+, protein phosphorylation and concurrent protein synthesis for zeatin signaling of acidic chitinase transcript accumulation in Cucumis sativus L.; Journal of Plant Physiology; (2001).

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