Dose Escalation of Metformin With Standard Chemotherapy Drugs in Children With Solid Tumors

Clinical Trial

Offered by: Nemours
Locations: Delaware Valley, Jacksonville, FL

Trial Name

A Phase I Trial of Dose Escalation of Metformin in Combination With Vincristine, Irinotecan, and Temozolomide in Children With Relapsed or Refractory Solid Tumors 16962
View on Clinicaltrials.gov »

What is the trial about?

To find the highest dose of Metformin that can be given safely in combination with standard chemotherapy drugs.

Who can participate?

Patients must be >1 year of age and ≤18 years of age at time of initiation of protocol therapy.

What is involved?

• Involvement will last for approximately 12 months. Patients will be seen in the clinic approximately 2 times a week while they are getting the treatments.
• Treatment on this study will consist of a combination of standard anti-cancer medications plus the study medication Metformin. The anti-cancer medications are vincristine, irinotecan and temozolomide (VIT).