Translational Rheumatology Lab

Translational Rheumatology Lab

About the Translational Rheumatology Lab

Under the direction of AnneMarie Brescia, MD, the Translational Rheumatology Lab focuses on research activities that can directly lead to new and effective treatment options for children with Juvenile Idiopathic Arthritis (JIA, formerly known as Juvenile Rheumatoid Arthritis) as well as Lyme arthritis.

The lab is part of the Center for Applied Clinical Genomics at Nemours Children’s Hospital, Delaware in Wilmington, Del. Our work has led to a number of publications and patents.

Lab Head

AnneMarie Brescia, MD, FAAP, FACR

Pediatric Rheumatologist
Assistant Professor of Pediatrics, Jefferson Medical College
Program Director, Fellowship Training in Pediatric Rheumatology

Current Research Group


Our Location:

Nemours Children’s Hospital, Delaware
1600 Rockland Road
Wilmington, DE 19803
Phone: (302) 651-5970
Fax: (302) 651-5942

Current Research Interests & Projects

Our current research efforts seek to:

  • Discover novel biomarkers for prognosis of JIA
  • Elucidate signaling pathways that are dysregulated and contribute to the pathogenesis of JIA
  • Characterize fibroblast-like synoviocytes (FLS) cultured from human synovial fluid to determine what role FLS play in the pathogenesis of JIA
  • Characterize FLS from acute and chronic Lyme arthritis