International Limb Differences Registry (ILDR)
Improving Understanding & Treatment of Limb Differences
The purpose of this registry is to collect information about patients with limb differences from various hospitals internationally. This information can then be used for research studies. These research studies will improve our understanding of medical conditions that affect upper and lower limbs, and improve treatment outcomes for patients.
Study Location | Status
Nemours Children’s Health, Delaware | Enrolling
Participant Eligibility
Clinical trials have inclusion and exclusion requirements that determine eligibility. Key requirements are listed below. Please note there may be additional qualifications.
Participants must be/have:
- Ages newborn to 18 years old.
- Diagnosed with an upper or lower limb difference.
- Additional diagnoses can include: Benign orthopedic tumors, Blount’s disease, congenital pseudarthrosis of tibia, fibular hemimelia, Morquio B, musculoskeletal infections, osteogenesis imperfecta, posteromedial bow of leg, post traumatic deformity, skeletal dysplasia.
About the Study
Formal Study Name: International Limb Differences Registry (ILDR)
Study Type: Observational (researchers observe and record without intervening)
Study ID: 109
Sponsor: University of British Columbia, Canada
Start Date: June 2025
Completion Date: Ongoing
Enrollment Goal: 110 participants
What’s Involved
Participants are only required to answer surveys approximately every six months.
How This Study Fits in
This study reflects our broader commitment at Nemours to improve care through research. Clinical trials like this one are shaped by the expertise of our medical teams and research programs. Learn how related research and clinical care support, and are strengthened by, studies like this one.
Limb Lengthening & Reconstruction
CLINICAL CARE
Specialists use innovative limb lengthening and reconstruction approaches, like 3D EOS imaging, computer-assisted surgery planning, and the latest fixation devices.
Orthopedic Center, Delaware Valley
CLINICAL CARE
Pediatric orthopedic care including neuromuscular, spine, and limb conditions at Nemours Children’s Hospital, Delaware and throughout Greater Philadelphia.
Orthopedics Clinical Trials
CLINICAL RESEARCH
We are conducting clinical trials to enhance diagnosis, treatment, and quality of life for children with various orthopedic conditions.
Orthopedics Research
RESEARCH AREA
Our teams study bone, joint, and muscle development to improve care for children with orthopedic conditions through innovation and collaboration.
More About Clinical Trials
Learn what to expect from a clinical trial — how they work, why they matter, and what to consider when deciding if one is right for your child.
Learn About Limb Differences From Nemours KidsHealth®
Limb differences are when an arm or leg is not shaped in the usual way. For example, a child's legs may be curved, or one might be shorter than the other. Or, a bone in the arm may be short or missing. Learn all about limb differences, treatments, and more from Nemours experts.