Dynamics in Epilepsy & Cognitive Development Lab
Understanding & Protecting Brain Development in Pediatric Epilepsy
The Nemours Children’s Dynamics in Epilepsy & Cognitive Development (DECODE) Lab in Delaware Valley is dedicated to understanding and treating one of childhood's most challenging neurological conditions: Epilepsy. With one in 26 people diagnosed with epilepsy during their lifetime, many in childhood, our work has never been more crucial.
We use cutting-edge technology to observe individual brain cells in action. This helps us understand how neural circuits control behavior and how seizures can disrupt healthy brain development. We’re especially interested in how two key brain regions communicate, the prefrontal cortex (which helps with complex thinking) and the hippocampus (where learning and memory take place).
Our research has led to exciting discoveries about ACTH, a naturally occurring hormone that shows promise in preventing cognitive challenges that can come with early-life seizures. By studying these neuropeptides (specialized brain signaling molecules) and how brain cells work together, we're uncovering new ways to treat children.
Through our research on conditions like tuberous sclerosis complex (TSC), we’re discovering why each child’s experience with epilepsy is unique, helping us develop more personalized treatments. For us, success means more than just controlling seizures. Success is giving every child the opportunity to learn, grow and reach their full potential.
Principal Investigator
Amanda Hernan, PhD
Research Scientist
LEARN MORE ABOUT OUR RESEARCH
- Focus Areas
- Notable Projects
- Grants & Partnerships
Our Areas of Focus
Our focus is studying cognitive impairment in pediatric epilepsy. Our projects center around several key areas.
Understanding Neural Networks in Development
The brain is a complex network of connected cells that control everything from thoughts to movements. We study how early-life seizures can disrupt these important connections as the brain develops. Using advanced recording techniques, we observe brain activity in real-time, focusing on regions responsible for thinking, learning, and memory. This helps us understand how seizures affect a child's ability to learn and process information and how we can help.
Discovering Neuropeptide Therapeutics
The body naturally produces molecules called neuropeptides that help brain cells communicate. One of these, ACTH, is already used to treat severe epilepsy in children. We're studying how ACTH and similar molecules might protect the brain from seizure-related cognitive challenges. By understanding how these molecules work, we can develop better treatments that not only control seizures but also protect a child's ability to learn and develop normally.
Studying Brain Cell Communication
The brain contains different types of cells that must work together for healthy development. Two key cells are neurons (which send electrical signals) and glia (which support and protect neurons). We're investigating how these cells interact during brain development, how seizures might disrupt their communication, and how we can protect these relationships.
Decoding Personalized Treatment Responses
Every child with epilepsy is unique, and what works for one child might not work for another. Through genetic studies and innovative research models, we're learning why these differences exist. This knowledge helps us move toward more personalized treatments that can be tailored to each child's specific needs.
Publications
Nemours researchers constantly contribute to advancing scientific understanding. We share our knowledge, insights, and discoveries to encourage collaboration and inspire further research.
Research in Context
Our labs contribute to research that informs pediatric care, working in alignment with research centers and focused areas of scientific study at Nemours.
Neuroscience Center, Delaware Valley
CLINICAL CARE
Pediatric neurology, epilepsy care, and neurodevelopmental services at Nemours Children’s Hospital, Delaware and throughout Greater Philadelphia.
Neuroscience Research
RESEARCH AREA
We investigate brain development and neurological disorders to advance pediatric neuroscience through collaboration and translational science.