Rasopathies Research Program

About the Rasopathies Research Program

Under the direction of Karen W. Gripp, MD, The Rasopathies Research program at Nemours/Alfred I. duPont Hospital for Children investigates Costello syndrome and a variety of genetic mutations referred to as rasopathies.

Research Interests

Costello syndrome, a rare genetic condition resulting from germline mutations in the proto-oncogene HRAS, is a multi-organ system disorder entailing a predisposition to malignant tumors. Dr. Gripp has a long standing interest in the clinical manifestations of Costello syndrome, and genotype-phentoype correlation.

Rasopathies: Genetic conditions resulting from mutations in genes encoding proteins of the Ras/MAPK signaling pathway are collectively referred to as rasopathies. These include the relatively common neurofibromatosis type 1 and Noonan syndrome, and the less common cardio-facio-cutaneous and Costello syndrome, amongst others.

Principal Investigator

Karen W. Gripp, MD, Director, Rasopathies Program

Chief, Division of Medical Genetics, Nemours/Alfred I. duPont Hospital for Children; and Professor of Pediatrics, Thomas Jefferson University
Learn More About Dr. Gripp »

Current Research Group

• Katia Sol-Church, PhD and her lab
• Beth Denenberg, LGC
• Daniel Doyle, MD
• Mihir Thacker, MD
• Angela Lin, MD
• Marni Axelrad, PhD