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- James P Franciosi, MD
Primary Office
Appointment: (407) 650-7715
Other Offices
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Nemours Children's Health, Downtown Orlando1717 S. Orange Ave.Orlando, FL 3280628.5227632-81.4456677Secondary
Appointment: (407) 650-7715
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Nemours Children's Health, Lake Mary3300 W. Lake Mary Blvd.Suite 100Lake Mary, FL 3274628.7568603-81.3389995Secondary
Appointment: (407) 650-7715
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Nemours Children's Health, Pensacola8331 N. Davis HighwayPensacola, FL 3251430.5128659-87.2218457Secondary
Appointment: (850) 505-4700
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Nemours Children's Health, Winter Garden2020 Daniels RoadSuite BWinter Garden, FL 3478728.5364581-81.585996Secondary
Appointment: (407) 650-7715
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Nemours Children's Health, Lakeland1324 Lakeland Hills Blvd.Lakeland Regional Health Medical Center, Suite ALakeland, FL 3380328.0593298-81.9549898Secondary
Appointment: (407) 650-7715
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Nemours Children's Health, Jacksonville807 Children's WayJacksonville, FL 3220730.312978-81.663158Secondary
Appointment: (904) 697-3600
Get to Know Me
I was born in Minnesota and grew up in Wisconsin playing ice hockey. Health care and caring for people is in my genes. My father, a pediatric pathologist, was my medical mentor, and my mother is a psychologist and a longtime advocate for mental health rights. I try to learn from every patient and family, and strive for improvement in medical care.Why I Treat Children
When I look at a child, I don’t just see their blood pressure and heart rate, but rather, I see a whole person and their family. Children have their whole lives in front of them; through no fault of their own they get sick, and it’s a privilege to have the opportunity to make them feel better.
What I Do For Fun
I'm married and have a daughter. We enjoy spending time as a family and with friends. I also enjoy golf, tennis, rollerblading, and water sports.
Education & Training
Fellowship
Pediatric Gastroenterology - Children's Hospital of Philadelphia, 2008
Residency
Surgery - University of Texas Southwestern Medical Center, 2003
Internship Residency
Pediatrics - The Children's Hospital of Philadelphia, 2005
Medical/Dental School
MD - Medical College of Wisconsin, 2001
Board Certifications
- American Board of Pediatrics/General Pediatrics
- American Board of Pediatrics/Gastroenterology
Insurance Accepted
- Accountable Health Plans PPO
- Aetna Better Health FL Medicaid and Healthy Kids
- Aetna HMO/POS/PPO/EPO
- AmeriHealth Caritas Florida (FKA Prestige Health Choice)
- AvMed
- Blue Cross Blue Shield Florida Blue Select
- Blue Cross and Blue Shield HMO
- Blue Cross and Blue Shield Non HMO
- Cigna & Great West HMO/POS Open Access
- Cigna & Great West PPO/EPO
- Community Care Plan Medicaid
- Employers Health Network PPO
- Evolutions Healthcare
- First Health Aetna PPO/EPO
- Florida Medicaid
- Florida Medicare
- HUMANA HEALTHY HORIZONS (FKA HUMANA MEDICAID)
- Health First Health Plans
- Humana HMO/POS
- Humana PPO/EPO
- Molina Healthcare Medicaid
- Multiplan PPO
- Olympus Managed Healthcare PPO ORL
- Prime Health Services PPO Specialty Florida
- Seminole Tribe of Florida
- Simply Healthcare Healthy Kids
- Simply Healthcare Medicaid HMO
- Star Healthcare Network
- Sunshine SMI/CMS 19 & 21
- Sunshine State Health Plan Medicaid
- Three Rivers Provider Network
- Tricare/Humana Military Health Services
- United Healthcare Commercial Products
- United Healthcare Community Plan Medicaid HMO
- Volusia Health Network PPO/EPO
- Celiac Disease
- Eosinophilic Esophagitis
- Feeding Disorders
- Inflammatory Bowel Disease
Research Activities
I serve as Associate Chief of the Division of Gastroenterology, Hepatology, and Nutrition at Nemours Children’s Hospital. My research focus is in pediatric Eosinophilic Esophagitis (EoE), with five first or co-authored publications on this topic in 2012. EOE is a rapidly emerging, chronic esophageal condition, as our understanding of disease pathogenesis is evolving. Specifically, the second iteration of Eosinophilic Esophagitis Consensus Guidelines, was published in 2011, makes distinctions between esophageal eosinophilia subtypes of confirmed EoE, gastroesophageal reflux disease and proton pump inhibitor (PPI) responsive esophageal eosinophilia. The mechanisms by which these different disease processes are generated are not fully understood. As these definitions are largely based on patients’ histopathological response to a clinical trial of PPI therapy, one consideration may be in the pharmacogenetic profiles of the PPI medications themselves. Recently, researchers at Nemours have shown that the pharmacokinetics and pharmacodynamics of PPIs are influenced by genetic polymorphisms that are associated with adverse respiratory events. Several variant alleles are loss-of-function alleles resulting in reduced drug clearance and in individuals being classified as poor metabolizers (PM); other alleles are associated with more rapid clearance and are responsible for the extensive metabolizers (EM) phenotype. Improved characterization of esophageal eosinophilia subtypes through PPI genotype characterization may allow for more rapid diagnosis and appropriate medical intervention. In addition, judicious use of PPI medications among patients with esophageal eosinophilia through personalized medicine techniques of genotype will also lessen the potential adverse impact of PPI-associated morbidity.
Medical Interests
- Eosinophilic GI disease and digestive tract food allergy
- Health outcomes (looking at how doctors can make life better for patients and their families)
- Inflammatory bowel disease (Crohn's disease and ulcerative colitis)
- Mougey, E. B., Saunders, M., Franciosi, J. P., & Gomez-Suarez, R. A. (2022). Comparative Effectiveness of Intravenous Azithromycin Versus Erythromycin Stimulating Antroduodenal Motility in Children. Journal of Pediatric Gastroenterology and Nutrition, 74(1), 25-32. doi:10.1097/MPG.0000000000003271
View Full Publication - Yasuda, J. L., Staffa, S. J., Nurko, S., Kane, M., Wall, S., Mougey, E. B., & Rosen, R. (2022). Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia. Neurogastroenterology and Motility, 34(1). doi:10.1111/nmo.14217
View Full Publication - Yasuda, J. L., Staffa, S. J., Nurko, S., Kane, M., Wall, S., Mougey, E. B., & Rosen, R. (2022). Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia. Neurogastroenterology and Motility, 34(1). doi:10.1111/nmo.14217
View Full Publication - Diaz, M. C. G., Werk, L. N., Crutchfield, J. H., Jr, Handy, L. K., Franciosi, J. P., Dent, J., & Wysocki, T. (2021). A provider-focused intervention to promote optimal care of pediatric patients with suspected elbow fracture. Pediatric Emergency Care, 37(12), E1663-E1669. doi:10.1097/PEC.0000000000001417
- Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., & Ginsburg, G. S. (2021). Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network (Genetics in Medicine, (2019), 21, 3, (743-747), 10.1038/s41436-018-0080-y). Genetics in Medicine, 23(10), 2020. doi:10.1038/s41436-020-01054-0
View Full Publication - Mougey, E. B., Nguyen, V., Gutierrez-Junquera, C., Fernandez-Fernandez, S., Cilleruelo, M. L., Rayo, A., & Franciosi, J. P. (2021). STAT6 Variants Associate With Relapse of Eosinophilic Esophagitis in Patients Receiving Long-term Proton Pump Inhibitor Therapy. Clinical Gastroenterology and Hepatology, 19(10), 2046-2053.e2. doi:10.1016/j.cgh.2020.08.020
View Full Publication - Lima, J. J., Thomas, C. D., Barbarino, J., Desta, Z., Van Driest, S. L., El Rouby, N., & Furuta, T. (2021). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. Clinical Pharmacology and Therapeutics, 109(6), 1417-1423. doi:10.1002/cpt.2015
View Full Publication - Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., & Ginsburg, G. S. (2020). Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network (Genetics in Medicine, (2019), 21, 3, (743-747), 10.1038/s41436-018-0080-y). Genetics in Medicine, 22(10), 1730. doi:10.1038/s41436-020-0911-5
View Full Publication - Berg, E. A., Picoraro, J. A., Miller, S. D., Srinath, A., Franciosi, J. P., Hayes, C. E., & LeLeiko, N. S. (2020). COVID-19:�A guide to rapid implementation of telehealth services: A playbook for the pediatric gastroenterologist. Journal of Pediatric Gastroenterology and Nutrition, 70(6), 734-740. doi:10.1097/MPG.0000000000002749
View Full Publication - Mougey, E. B., Williams, A., Coyne, A. J. K., Gutierrez-Junquera, C., Fernandez-Fernandez, S., Cilleruelo, M. L., & Franciosi, J. P. (2019). CYP2C19 and STAT6 Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis. Journal of Pediatric Gastroenterology and Nutrition. doi:10.1097/MPG.0000000000002480
View Full Publication - Diaz, M. C. G., Wysocki, T., Crutchfield, J. H., Jr, Franciosi, J. P., & Werk, L. N. (2019). Provider-Focused Intervention to Promote Comprehensive Screening for Adolescent Idiopathic Scoliosis by Primary Care Pediatricians. American Journal of Medical Quality, 34(2), 182-188. doi:10.1177/1062860618792667
View Full Publication - Cicali, E. J., Blake, K., Gong, Y., Mougey, E. B., Al-Atrash, H., Chambers, N., & Franciosi, J. P. (2019). Novel Implementation of Genotype-Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial. Clinical and Translational Science, 12(2), 172-179. doi:10.1111/cts.12589
View Full Publication - Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., & Ginsburg, G. S. (2019b). Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genetics in Medicine, 21(3), 743-747. doi:10.1038/s41436-018-0080-y
View Full Publication - Tang, M., Blake, K. V., Lima, J. J., Mougey, E. B., Franciosi, J., Schmidt, S., & Lang, J. E. (2019). Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods. Contemporary Clinical Trials, 78, 27-33. doi:10.1016/j.cct.2019.01.009
View Full Publication - Werk, L. N., Diaz, M. C., Cadilla, A., Franciosi, J. P., & Hossain, M. J. (2019). Promoting Adherence to Influenza Vaccination Recommendations in Pediatric Practice. Journal of Primary Care and Community Health, 10. doi:10.1177/2150132719853061
View Full Publication - Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., & Ginsburg, G. S. (2019a). Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network (Genetics in Medicine, (2019), 21, 3, (743-747), 10.1038/s41436-018-0080-y). Genetics in Medicine, 21(7), 1670. doi:10.1038/s41436-018-0280-5
View Full Publication - Cicali, E. J., Weitzel, K. W., Elsey, A. R., Orlando, F. A., Vinson, M., Mosley, S., & Johnson, J. A. (2019). Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings. Genetics in Medicine, 21(10), 2264-2274. doi:10.1038/s41436-019-0500-7
View Full Publication - Klinnert, Atkins, D., Pan, Z., Franciosi, J. P., Aceves, S. S., Spergel, J. M., & Furuta, G. T. (2019). Symptom Burden and Quality of Life over Time in Pediatric Eosinophilic Esophagitis. Journal of Pediatric Gastroenterology and Nutrition, 69(6), 682-689. doi:10.1097/MPG.0000000000002479
View Full Publication - Franciosi, J. P., Mougey, E. B., Williams, A., Gomez Suarez, R. A., Thomas, C., Creech, C. L., & Lima, J. J. (2018). Association between CYP2C19 extensive metabolizer phenotype and childhood anti-reflux surgery following failed proton pump inhibitor medication treatment. European Journal of Pediatrics, 177(1), 69-77. doi:10.1007/s00431-017-3051-4
View Full Publication - Franciosi, J. P., Mougey, E. B., Williams, A., Gomez-Suarez, R. A., Thomas, C., Creech, C. L., & Lima, J. J. (2018). Association Between CYP2C19*17 Alleles and pH Probe Testing Outcomes in Children With Symptomatic Gastroesophageal Reflux. Journal of Clinical Pharmacology, 58(1), 89-96. doi:10.1002/jcph.977
View Full Publication - Wysocki, T., Diaz, M. C. G., Crutchfield, J. H., Jr, Franciosi, J. P., & Werk, L. N. (2017). Electronic health record as a research tool: Frequency of exposure to targeted clinical problems and health care providers' clinical proficiency. Journal of Biomedical Informatics, 70, 14-26. doi:10.1016/j.jbi.2017.04.016
View Full Publication - Cavallari, L. H., Beitelshees, A. L., Blake, K. V., Dressler, L. G., Duarte, J. D., Elsey, A., & Johnson, J. A. (2017). The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting. Clinical and Translational Science, 10(3), 143-146. doi:10.1111/cts.12456
View Full Publication - Kruszewski, P. G., Russo, J. M., Franciosi, J. P., Varni, J. W., Platts-Mills, T. A. E., & Erwin, E. A. (2016). Prospective, comparative effectiveness trial of cow's milk elimination and swallowed fluticasone for pediatric eosinophilic esophagitis. Diseases of the Esophagus, 29(4), 377-384. doi:10.1111/dote.12339
View Full Publication - Varni, J. W., Bendo, C. B., Nurko, S., Shulman, R. J., Self, M. M., Franciosi, J. P., & Pohl, J. F. (2015). Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatrics, 166(1), 85-90.e2. doi:10.1016/j.jpeds.2014.08.022
View Full Publication - Varni, J. W., Franciosi, J. P., Shulman, R. J., Saeed, S., Nurko, S., Neigut, D. A., & Pohl, J. F. (2015). PedsQL gastrointestinal symptoms scales and gastrointestinal worry scales in pediatric patients with inflammatory bowel disease in comparison with healthy controls. Inflammatory Bowel Diseases, 21(5), 1115-1124. doi:10.1097/MIB.0000000000000351
View Full Publication - Mercer, R. W., Schwartz, M. C., Stephany, J., Donnelly, L. F., Franciosi, J. P., & Epelman, M. (2015). Vascular ring complicates accidental button battery ingestion. Clinical Imaging, 39(3), 510-512. doi:10.1016/j.clinimag.2015.01.009
View Full Publication - Martin, L. J., Franciosi, J. P., Collins, M. H., Abonia, J. P., Lee, J. J., Hommel, K. A., & Rothenberg, M. E. (2015). Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. Journal of Allergy and Clinical Immunology, 135(6), 1519-1528.e8. doi:10.1016/j.jaci.2015.03.004
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