Jonathan L. Powell, MD


Primary Office

Nemours Children's Hospital, Delaware Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803 Appointment: (800) 416-4441

Other Offices

Get to Know Me

I am married to a wonderful woman, and we have three adopted boys from Colombia, five cats, and a house full of craziness and love. My kids are the hardest and best part of my day, every day, and seeing them grow and mature into young men makes me grateful to be alive. They are my heart and my soul, and I have no words for that kind of blessing.

Why I Treat Children

I have always appreciated the laughter and spontaneity of children, their sweetness, their complexity, and their straightforward way of just trying to get the most fun possible out of life. I really enjoy keeping kids smiling and happy.

What I'm Passionate About

I was recently invited to the 10-year cancer free anniversary party of one of my patients. What joy to see him grow. That helps keep me going. I am also passionate about our bone marrow transplantation program, both for children with cancer and for children with non-oncologic disease.

How I Try to Make A Difference

When I was in college, I had a chance to work in a rural Mexico clinic as a translator. I was inspired by the physicians – they worked so hard, with so little, and made a huge difference for people who had no other chance. Today I enjoy helping families who need Spanish to communicate with their physician.

Education & Training


  • Hematology/Oncology - The Children's Hospital of Philadelphia, 2004

Internship Residency

  • Pediatrics - The Children's Hospital of Philadelphia, 2001

Medical/Dental School

  • MD - University of Texas Southwestern Medical Center, 1998

Board Certifications

  • American Board of Pediatrics/Pediatric Hematology-Oncology

Insurance Accepted

  • Aetna Better Health FL Medicaid and Healthy Kids
  • Aetna Better Health PA Kids HMO
  • Aetna HMO
  • Aetna PPO/POS/EPO
  • Amerihealth Caritas Delaware
  • Blue Cross and Blue Shield HMO
  • Blue Cross and Blue Shield Non HMO
  • Blue Cross Blue Shield Florida Blue Select
  • Cigna & Great West HMO/POS Open Access
  • Cigna & Great West PPO/EPO
  • Cigna/Great West HMO EPO POS
  • Cigna/Great West PPO
  • Community Care Plan Medicaid
  • Delaware First Health
  • Delaware Medicaid/Diamond State
  • Delaware Medicare
  • Devon Health Services
  • Employers Health Network PPO
  • Evolutions Healthcare
  • Fidelis Care NJ Medicaid HMO
  • First Health Aetna PPO/EPO
  • First Health/Affordable PPO
  • Florida Medicaid
  • Geisinger Health Plan Commercial
  • Global Medical Managment DE/PA
  • Health First Health Plans
  • Health Partners Medicaid/Kidz Partner HMO
  • HealthSmart Health Plans PPO
  • Highmark Blue Cross Blue Shield of Delaware
  • Highmark Blue Cross Blue Shield of Delaware *PA Loc Contiguous to DE*
  • Highmark Blue Cross Blue Shield of Delaware *PA Loc NONContiguous to DE*
  • Highmark Blue Cross Blue Shield of Pennsylvania
  • Highmark Medicaid Health Options
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana HMO/POS
  • Humana PPO/EPO
  • Independance Blue Cross/Amerihealth/Keystone Health Plan
  • Insurance Administrators of America
  • INTEGRA Administrative Group (ClaimsBridge)
  • Keystone First Medicaid HMO
  • Lifetrac Transplant
  • Maryland Medicaid
  • Molina Healthcare Medicaid
  • Multiplan PPO
  • National Transplant (Humana)
  • New Jersey Medicaid
  • Olympus Managed Healthcare PPO ORL
  • Pennsylvania Medicaid
  • Plan Vista/NPPN PPO
  • Preferred Healthcare PPO
  • Private Health Care Systems (PHCS)
  • Qualcare HMO/POS/PPO
  • Seminole Tribe of Florida
  • Simply Healthcare Healthy Kids
  • Simply Healthcare Medicaid HMO
  • Star Healthcare Network
  • Sunshine SMI/CMS 19 & 21
  • Sunshine State Health Plan Medicaid
  • Three Rivers Provider Network
  • Tricare/Humana Military Health Services/CHAMPVA
  • United Healthcare Commercial Products
  • United Healthcare Community Plan Medicaid
  • United Healthcare of the Mid-Atlantic
  • US Family Health Plan
  • Volusia Health Network PPO/EPO
  • Wellpoint Maryland Medcaid

  • Blood and Bone Marrow Transplantation
  • Blood Disorders
  • Bone Tumors
  • Cancer Care
  • Leukemia
  • Lymphoma
  • Neuroblastoma
  • Neutropenia
  • Platelet Abnormalities
  • Solid Tumors

Medical Interests

  • Coagulation disorders
  • Hemophagocytic lymphohistiocytosis
  • Lymphomas
  • Pediatric strokes
  • Soft tissue sarcomas

  • Successful Crizotinib-Targeted Therapy of Pediatric Unresectable ERC1::ALK Fusion Sarcoma; Unknown Source; (2023).

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  • Sporadic extranodal Rosai-Dorfman-Destombes disease treated with tocilizumab; Pediatric Blood & Cancer; (2022).

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  • Fusion-negative rhabdomyosarcoma with diffuse bony metastases and remarkable chemosensitivity; BMJ Case Reports; (2022).

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  • Aggressive Hematopoietic Malignancy Characterized by Biallelic Loss of SMARCB1; JCO Precision Oncology; (2020).

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  • A novel and successful therapeutic approach in the treatment of a patient with simultaneous relapsed Ewing sarcoma and therapy-related acute myeloid leukemia; Pediatric Blood & Cancer; (2020).

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  • Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain-of-function; Blood; (2020).

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  • Topical Amphotericin B in Combination With Standard Therapy for Severe Necrotizing Skin and Soft-Tissue Mucormycosis in an Infant With Bilineal Leukemia; Journal of Pediatric Hematology/Oncology; (2014).

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  • An unexpectedly high incidence of Epstein-Barr virus lymphoproliferative disease after CD34+ selected autologous peripheral blood stem cell transplant in neuroblastoma; Bone Marrow Transplantation; (2004).

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  • English
  • Spanish