Matthew D. Di Guglielmo, MD, PhD

Consultative Pediatrics

Primary Office

Nemours Children's Hospital, Delaware Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803 Appointment: (800) 416-4441

Get to Know Me

I am a Delaware native and grew up in Wilmington. I am married, with two daughters, and come from a family that enjoys music, cooking, and eating. One of the most rewarding parts of my work is when babies I have seen in the nursery, on their first day of life, grow up into active toddlers and children.

Why I Treat Children

During my childhood and as an adolescent, I had terrific doctors who were role models, and they inspired me to go into medicine. When I was in medical school, I also had great experiences with the people working in pediatrics. Kids grow so much between birth and college-age. I have always enjoyed caring for children during this rapid-development period.

What I'm Passionate About

I was always interested in science and have a strong interest in improving health care outcomes for the children I care for. A lot of this came from my experience with the health care system and members of my own family. My research interests center on improving everyone’s access to quality health care.

Education & Training

Internship Residency

  • Pediatrics - Nemours/Alfred I. duPont Hospital for Children, 2007

Medical/Dental School

  • MD/PhD - Jefferson Medical College, 2004

Board Certifications

  • American Board of Pediatrics/General Pediatrics

Awards & Recognition

  • 2014 Delaware Today magazine, Top Doctors

Insurance Accepted

  • Aetna Better Health PA Kids HMO
  • Aetna HMO
  • Aetna PPO/POS/EPO
  • Amerihealth Caritas Delaware
  • Carefirst MD Community Health Plan Mcaid
  • Cigna Lifesource Transplant
  • Cigna/Great West HMO EPO POS
  • Cigna/Great West PPO
  • Delaware First Health
  • Delaware Medicaid/Diamond State
  • Delaware Medicare
  • Devon Health Services
  • Fidelis Care NJ Medicaid HMO
  • First Health/Affordable PPO
  • Geisinger Health Plan Commercial
  • Global Medical Managment DE/PA
  • Health Partners Medicaid/Kidz Partner HMO
  • Highmark Blue Cross Blue Shield of Delaware
  • Highmark Medicaid Health Options
  • Horizon Blue Cross Blue Shield of New Jersey
  • Independance Blue Cross/Amerihealth/Keystone Health Plan
  • Insurance Administrators of America
  • INTEGRA Administrative Group (ClaimsBridge)
  • Keystone First Medicaid HMO
  • Lifetrac Transplant
  • Maryland Medicaid
  • Multiplan PPO
  • National Transplant (Humana)
  • New Jersey Medicaid
  • Olympus Managed Healthcare PPO DE/PA
  • Pennsylvania Medicaid
  • Plan Vista/NPPN PPO
  • Preferred Healthcare PPO
  • Private Health Care Systems (PHCS)
  • Qualcare HMO/POS/PPO
  • Star Healthcare Network
  • Three Rivers Provider Network
  • Tricare/Humana Military Health Services
  • United Healthcare of the Mid-Atlantic
  • US Family Health Plan
  • Wellpoint Maryland Medicaid

Medical Interests

  • Access to health care
  • Education of new parents and caregivers
  • Healthy growth and development
  • Improving nutrition and food choices
  • Newborn care
  • Translational medicine
  • Utilization of health care services
  • Vaccines and public health

  • The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity; Pediatric Gastroenterology, Hepatology & Nutrition; (2021).

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  • Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity; Pediatric and Developmental Pathology; (2018).

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  • A Pilot Study Measuring The Novel Satiety Hormone, Pro-Uroguanylin, In Adolescents With And Without Obesity; Journal of Pediatric Gastroenterology and Nutrition; (2017).

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  • General Pediatrician-Staffed Behavioral/Developmental Access Clinic Decreases Time to Evaluation of Early Childhood Developmental Disorders; Journal of Developmental and Behavioral Pediatrics; (2017).

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  • Pediatrician preferences, local resources, and economic factors influence referral to a subspecialty access clinic; Primary Health Care Research and Development; (2016).

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  • Female Adolescent Presenting With Abdominal Pain: Accidental Wire Bristle Ingestion Leading to Colonic Perforation; Pediatric Emergency Care; (2015).

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  • A new model to decrease time-to-appointment wait for gastroenterology evaluation; Pediatrics; (2013).

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  • Aortic pseudoaneurysm in a child with a left mainstem bronchial stent; Pediatric Critical Care Medicine; (2008).

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  • Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C; FEBS Letters; (2001).

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  • Guanylyl cyclase C (GC-C) inhibits human colon carcinoma cell growth; Clinical Pharmacology and Therapeutics; (2001).

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  • Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells; Proceedings of the National Academy of Sciences of the United States of America; (2001).

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  • English