Yu Miles Yu, MD

Endocrinology

Primary Office

Nemours Children's Hospital, Florida Nemours Children's Hospital, Florida 6535 Nemours Parkway Orlando, FL 32827 Appointment: (407) 650-7715

Other Offices

Get to Know Me

My profession gives me the opportunity to help a lot of people everyday – children and adults – in significant ways. As a pediatric endocrinologist with two great children of my own, I do my best to treat each child I care for as my own and do whatever it takes to address their medical problems.

Why I Treat Children

I love treating children because I use my knowledge about pediatric endocrinology to help them get better quickly. It’s a good feeling to know many of them will grow up to be healthy adults with less risk of developing some of the illnesses commonly seen later in life.

What I'm Passionate About

Sometimes I see children who are experiencing medical problems without knowing what’s really wrong. Making the correct diagnosis is important, even if it’s distressful at first for the child and family. Because that’s the first step toward starting the right treatment, and helping that child reach his or her full potential.

Education & Training

Fellowship

  • Pediatric Endocrinology - University of North Carolina Hospital, 2000

Residency

  • Pediatrics - Inova Health System, 1998
  • Pediatrics - University of Maryland Medical System, 1996
  • Pediatrics - Children's Hospital of Shanghai Medical University, 1985

Medical/Dental School

  • MD - Medical Center of Fudan University, 1984
  • No Degree Awarded - University of Nebraska, College of Medicine, 1989

Board Certifications

  • American Board of Pediatrics/Pediatric Endocrinology
  • American Board of Pediatrics/General Pediatrics

Insurance Accepted

  • Aetna Better Health FL Medicaid and Healthy Kids
  • Aetna HMO/POS/PPO/EPO
  • AmeriHealth Caritas Florida (FKA Prestige Health Choice)
  • AvMed
  • Blue Cross and Blue Shield HMO
  • Blue Cross and Blue Shield Non HMO
  • Blue Cross Blue Shield Florida Blue Select
  • Cigna & Great West HMO/POS Open Access
  • Cigna & Great West PPO/EPO
  • Community Care Plan Medicaid
  • Employers Health Network PPO
  • Evolutions Healthcare
  • First Health Aetna PPO/EPO
  • Florida Medicaid
  • Florida Medicare
  • Health First Health Plans
  • HEALTHSMART HLTH PLANS PPO ORL
  • HUMANA HEALTHY HORIZONS (FKA HUMANA MEDICAID)
  • Humana HMO/POS
  • Humana PPO/EPO
  • Molina Healthcare Medicaid
  • Multiplan PPO
  • Olympus Managed Healthcare PPO ORL
  • Prime Health Services PPO Specialty Florida
  • Seminole Tribe of Florida
  • Simply Healthcare Healthy Kids
  • Simply Healthcare Medicaid HMO
  • Star Healthcare Network
  • Sunshine SMI/CMS 19 & 21
  • Sunshine State Health Plan Medicaid
  • Three Rivers Provider Network
  • Tricare/Humana Military Health Services
  • United Healthcare Commercial Products
  • United Healthcare Community Plan Medicaid
  • Volusia Health Network PPO/EPO

  • Adrenal Disease
  • Diabetes
  • Pituitary Disease
  • Puberty Disorders
  • Short Stature
  • Thyroid Disease
  • Thyroid Nodules and Cancer

Research Activities

A large number of my patients have metabolic problems associated with excessive weight gain. My research interests center on developing sensible, but practical care plans for children, so they can enjoy happier, healthier lives.

Medical Interests

  • Diabetes insipidus
  • Diabetes type 1 and type 2
  • Growth and puberty problems
  • Metabolic disorders related to excessive weight, adrenal problems, rickets or other metabolic bone diseases
  • Thyroid problems

  • Special Issue "In Vivo Nuclear Molecular Imaging in Drug Development and Pharmacological Research"; Pharmaceuticals; (2023).

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  • Abusive Head Trauma Animal Models: Focus on Biomarkers; International Journal of Molecular Sciences; (2023).

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  • Birth-related subdural hemorrhage: prevalence and imaging morphology; Pediatric Radiology; (2021).

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  • Radiosynthesis of 1-(2-[18f]fluoroethyl)-l-tryptophan using a one-pot, two-step protocol; Journal of Visualized Experiments; (2021).

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  • Unravelling neuroinflammation in abusive head trauma with radiotracer imaging; Pediatric Radiology; (2021).

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  • Automated production of 1-(2-[18F]fluoroethyl)-L-tryptophan for imaging of tryptophan metabolism; Applied Radiation and Isotopes; (2020).

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  • PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model; Scientific Reports; (2020).

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  • Automated production of a N-methyl-D-aspartate receptor radioligand [ 18 F]GE179 for clinical use; Applied Radiation and Isotopes; (2019).

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  • Enzymatic activity of palmitoyl-protein thioesterase-1 in serum from schizophrenia significantly associates with schizophrenia diagnosis scales; Journal of Cellular and Molecular Medicine; (2019).

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  • Kinetic modeling of [ 18 F]VAT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain; Journal of Neurochemistry; (2018).

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  • Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter; Bioorganic and Medicinal Chemistry Letters; (2018).

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  • In Vivo Characterization of Two 18 F-Labeled PDE10A PET Radioligands in Nonhuman Primate Brains; ACS Chemical Neuroscience; (2018).

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  • Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation; Bioorganic and Medicinal Chemistry Letters; (2018).

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  • Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis; Journal of Neuroimmunology; (2018).

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  • Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands; Bioorganic and Medicinal Chemistry Letters; (2018).

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  • Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease; European Journal of Pharmacology; (2018).

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  • Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques; Molecular Imaging and Biology; (2018).

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  • Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (--)-[18F]TZ3108 in rodent and the nonhuman primate brain; Bioorganic and Medicinal Chemistry; (2017).

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  • PET study of sphingosine-1-phosphate receptor 1 expression in response to vascular inflammation in a rat model of carotid injury; Molecular Imaging; (2017).

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  • Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate; Org. Biomol. Chem.; (2017).

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  • Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter; Applied Radiation and Isotopes; (2016).

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  • Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates; Nuclear Medicine and Biology; (2016).

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  • Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates; Pharmacology Research and Perspectives; (2016).

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  • Design, Synthesis, and in Vitro and in Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer; Journal of Medicinal Chemistry; (2016).

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  • PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis; Molecular Imaging and Biology; (2016).

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  • A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression; Organic and Biomolecular Chemistry; (2015).

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  • Radiation dosimetry of [18F]VAT in nonhuman primates; EJNMMI Research; (2015).

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  • Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject; NeuroImage; (2015).

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  • Lack of neuroinflammation in the HIV-1 transgenic rat: An [18F]-DPA714 PET imaging study; Journal of Neuroinflammation; (2015).

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  • Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter; Bioorganic and Medicinal Chemistry; (2015).

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  • PET and NIR optical imaging using self-illuminating 64Cu-doped chelator-free gold nanoclusters; Biomaterials; (2014).

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  • Dye-Loaded Ferritin Nanocages for Multimodal Imaging and Photothermal Therapy; Advanced Materials; (2014).

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  • Longitudinal PET imaging of muscular inflammation using 18F-DPA-714 and 18F-alfatide II and differentiation with tumors; Theranostics; (2014).

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  • Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS; Molecular Pharmaceutics; (2014).

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  • One-pot two-step radiosynthesis of a new 18F-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging; Molecular Pharmaceutics; (2014).

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  • A symmetrical fluorous dendron-cyanine dye-conjugated bimodal nanoprobe for quantitative 19f MRI and NIR fluorescence bioimaging; Advanced Healthcare Materials; (2014).

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  • PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714; European Journal of Nuclear Medicine and Molecular Imaging; (2014).

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  • Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy; Theranostics; (2014).

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  • [18F]DPA-714 PET imaging of AMD3100 treatment in a mouse model of stroke; Molecular Pharmaceutics; (2014).

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  • Development of a new thiol site-specific prosthetic group and its conjugation with [Cys40]-exendin-4 for in vivo targeting of insulinomas; Bioconjugate Chemistry; (2013).

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  • Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging; Biomaterials; (2013).

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  • Synthesis and characterization of fluorinated conjugates of albumin; Journal of Fluorine Chemistry; (2013).

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  • PH-sensitive fluorescent dyes: Are they really ph-sensitive in cells?; Molecular Pharmaceutics; (2013).

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  • Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy; Biomaterials; (2013).

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  • Avoiding steric congestion in dendrimer growth through proportionate branching: A twist on da Vincis rule of tree branching; Journal of Organic Chemistry; (2012).

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  • Fluorine-Containing Chiral Drugs; Chiral Drugs: Chemistry and Biological Action; (2011).

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  • Palladium-catalyzed cross-coupling of ethyl α-bromo-α- fluoroacetate with arylboronic acids: Facile synthesis of α-aryl-α- fluoroacetate; Synthesis; (2010).

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  • A practical approach to synthesize the C(9)-C(24) fragment of (+)-discodermolide; Chinese Journal of Chemistry; (2010).

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  • Cu(II)-mediated methylthiolation of aryl C-H bonds with DMSO; Organic Letters; (2010).

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  • Total synthesis of gem-difluoromethylenated analogues of pironetin; Synthesis; (2010).

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  • Highly diastereoselective zn/sncl2-mediated gem- difluoroallylation of chiral hydrazones; Organic Letters; (2009).

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  • Metal-mediated gem-difluoroallylation of N-acylhydrazones: Highly efficient synthesis of α,α-difluorohomoallylic amines; Chinese Journal of Chemistry; (2009).

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  • Synthesis of 2',3'-dideoxy-6',6'-difluoro-3'-azanucleosides; Journal of Fluorine Chemistry; (2008).

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  • Synthesis of gem-difluoromethylenated goniodiol; Chinese Journal of Organic Chemistry; (2008).

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  • Synthesis of a series of novel 2',3'-dideoxy-6',6'-difluoro-3'-thionucleosides; Tetrahedron; (2007).

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