Dose Escalating and Safety Trial of Metformin With Induction Chemotherapy in Lymphoblastic Leukemia

Clinical Trial

Offered by: Nemours Children's Health, Jacksonville
Location: Jacksonville, Fla.

Trial Name

A Phase I Window, Dose Escalating and Safety Trial of Metformin in Combination With Induction Chemotherapy in Relapsed Refractory Acute Lymphoblastic Leukemia: Metformin With Induction Chemotherapy of Vincristine, Dexamethasone, Doxorubicin, and PEG-Aspar

What is the trial about?

A research study of a drug called Metformin in combination with standard chemotherapy for the treatment of patients with relapsed or refractory solid tumors.

Who can participate?

Male or female age 1-30 years at initial diagnosis.

What is involved?

Length of study is 6 months. Standard cancer care including medical history, physical exam, blood work, urine pregnancy test, ECG or MUGA, bone marrow aspirate, and/or biopsy.