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EoE GI Disease Center                                                                  

What Is Eosinophilic Esophagitis?

Eosinophilic esophagitis (also called EoE for short), is a chronic inflammatory condition of the food tube (esophagus: ih-SOF-eh-guss) often caused by a reaction to common foods.

What are eosinophils cells?

Eosinophils are a type of white blood cell. Together with basophils and mast cells, eosinophils are important mediators of the allergic response in EoE and symptom severity is a function of the number of eosinophils found in the esophagus. 

Learn More About EoE

Common EoE Symptoms

Because EoE can mimic other GI conditions, it's important to confirm your child's diagnosis with a specialist. Your child may also need extra help with feeding and nutrition because symptoms usually include: 

  • Difficulty eating or swallowing
  • Nausea or vomiting
  • Food getting stuck 
  • Chest or abdominal pain
  • Poor weight gain

Treatment Options for Eosinophilic Esophagitis (EoE)


Proton pump inhibitors (PPIs) are a kind of acid-reducing medications that can help controlling EoE. Topical steroids can be used to coat the esophagus lining and improve EoE. Examples may include: budesonide and pulmicort or fluticasone. 

Resources for Diet and Food Removal

Because EoE can be triggered by foods, the doctor may advise a trial of removing certain foods to control EoE. Common triggering foods may include milk, soy, egg, wheat, fish/shellfish, peanuts/tree nuts. Here are some resources from Nemours KidsHealth experts to learn more:

How Is EoE Diagnosed?

To make the diagnosis, a pediatric GI specialist takes samples (called biopsies) from the lining of the esophagus with a thin camera that is gently slid down the mouth into the esophagus, stomach and intestine. This upper GI test is called  an endoscopy. It's done as an outpatient and with sedation or anesthesia so your child is not uncomfortable.

Management of Eosinophilic Esophagitis (EoE)

Because EoE is a chronic condition, treatment is continued long-term. Although treatment does not cure EoE, it controls your child's symptoms, discomfort and prevents complications.

Ongoing monitoring with repeating biopsies may be done to make sure inflammation and other medical issues related to EoE are well controlled.

Visit our services page to get an idea of what we do in our EoE GI Disease Center at Nemours Children's, including an upper GI test that doesn't require anesthesia (unsedated transnasal endoscopy or "TNE").  We use the EndoflipTM (endoluminal functional lumen imaging probe) an advanced technology to help us see and measure inside the esophagus.

View Our Services

Mind-Body Connection

Three tween-aged kids hold a yoga pose in a studio

In addition to medications and diet, our EoE experts recommend tools and techniques to help kids with GI conditions function better at home, at school and during procedures. They include things like:

  • Apps to calm your mind and body
  • Breathing exercises
  • Guided meditation
  • Yoga and other kinds of movement
Finding Your Zen

Nutritional Support and Daily Life

Zeke sets nutriition goals with his EoE team and even scores a few on the ice as a 16-year-old hockey player. 

MTV True Life - Zeke has conference call with Dr. James Franciosi for biopsy results and to plan next EoE food trials as a team.

Nutritional Support Hypoallergenic formulas for patients with food allergy-related conditions. Amino Acid-based diet formulas for infants and children who cannot tolerate intact or hydrolyzed protein due to food allergies or short bowel syndrome. (PurAmino) A global company focused primarily on infant and child nutrition. 

Living With EoE

Diet and Food Removal

Because EoE can be triggered by foods in some kids, the doctor may advise a systematic trial of eliminating certain foods to control EoE. Common triggering foods may include milk, soy, egg, wheat, fish/shellfish, peanuts/tree nuts.

Support Organizations

These groups offer everything from help with school (Kindergarten to college), annual conferences, and more.

Take a Tour of the Digestive System

Presented by the experts at Nemours KidsHealth, this journey through your digestive system will help you understand how the food you eat works its way through your body from start to finish.