Rodney Scott, MD

Neurology

Primary Office

Nemours Children's Hospital, Delaware Nemours Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803 Appointment: (800) 416-4441

Other Offices

Get to Know Me

Dr. Rodney Scott straddles the interface between basic and clinical science, enabling him to carry out and lead multidisciplinary research projects, with scientific findings that have major clinical implications. He has expertise in the design of clinically relevant experiments and in translating basic science findings within a clinical framework. He applies these findings in his clinical practice that, over the last 2 decades, has concentrated on the care of children with epilepsy, particularly those with status epilepticus and those with additional cognitive and behavioral impairments. 

Why I Treat Children

Children with neurological disorders are often vulnerable. Providing high quality care allows these children to make maximal quality of life gains that minimizes these vulnerabilities, thereby enabling their roles in society.

What I'm Passionate About

I am passionate about the management of severe epilepsies, and I emphasize the importance of quality of life, moving beyond the traditional approach of seizure reduction as the most important outcome for these children. 

How I Try to Make A Difference

I aim to integrate high quality clinical care with cutting edge research to ensure that I am providing the most up to date information to children with neurological diseases and their families. 

Education & Training

Internship

  • Neurosurgery - Harare Central Hospital, 1989
  • General Surgery - Harare Central Hospital, 1989
  • Oncology - Parirenyatwa General Hospital, 1989

Residency

  • Pediatric Neurology - Great Ormond Childrens Hospital, 2000

Internship Residency

  • Academic General Pediatrics - Chelsea & Westminster Hospital, 1994

Medical/Dental School

  • MBChB - University of Zimbabwe, 1988
  • Doctor of Philosophy - University College London, 1999

Board Certifications

  • Royal College of Physicians United Kingdom

Insurance Accepted

  • Aetna Better Health PA Kids HMO
  • Aetna HMO
  • Aetna PPO/POS/EPO
  • Carefirst MD Community Health Plan Mcaid
  • Cigna Lifesource Transplant
  • Cigna/Great West HMO EPO POS
  • Cigna/Great West PPO
  • Delaware First Health
  • Delaware Medicaid/Diamond State
  • Delaware Medicare
  • Devon Health Services
  • Fidelis Care NJ Medicaid HMO
  • First Health/Affordable PPO
  • Geisinger Health Plan Commercial
  • Global Medical Managment DE/PA
  • Health Partners Medicaid/Kidz Partner HMO
  • Highmark Blue Cross Blue Shield of Delaware
  • Highmark Medicaid Health Options
  • Horizon Blue Cross Blue Shield of New Jersey
  • Independance Blue Cross/Amerihealth/Keystone Health Plan
  • INTEGRA Administrative Group (ClaimsBridge)
  • Keystone First Medicaid HMO
  • Maryland Medicaid
  • Multiplan PPO
  • New Jersey Medicaid
  • Pennsylvania Medicaid
  • Plan Vista/NPPN PPO
  • Private Health Care Systems (PHCS)
  • Qualcare HMO/POS/PPO
  • Tricare/Humana Military Health Services/CHAMPVA
  • United Healthcare of the Mid-Atlantic
  • UPMC MCAID/CHIP PA DE
  • US Family Health Plan
  • Wellpoint Maryland Medcaid

  • Epilepsy

Research Activities

My research investigates the relationships between epilepsy and cognitive impairments using human cohort and animal model studies. The emphasis is on characterizing and manipulating brain networks to improve treatments for people with epilepsy.

  • MRI for assessing the impact of febrile status epilepticus and predicting outcomes; Febrile Seizures: New Concepts and Consequences; (2022).

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  • Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures; Neurobiology of Disease; (2022).

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  • Biological networks and complexity in early-onset motor neuron diseases; Frontiers in Neurology; (2022).

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  • Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures; Unknown Source; (2022).

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  • Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions; Communications Biology; (2022).

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  • Seizure outcome determinants in children after surgery for single unilateral lesions on MRI : role of preoperative ictal and interictal EEG; Epilepsia; (2022).

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  • Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?; Brain; (2022).

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  • Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures; Frontiers in Neurology; (2022).

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  • The UK experience of stereoelectroencephalography in children: An analysis of factors predicting the identification of a seizure-onset zone and subsequent seizure freedom; Epilepsia; (2021).

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  • The UK experience of stereoelectroencephalography in children: An analysis of factors predicting the identification of a seizure onset zone and subsequent seizure freedom; medRxiv; (2021).

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  • Levetiracetam for treatment of convulsive status epilepticus: Time to update childhood convulsive status epilepticus treatment guidelines?; Archives of Disease in Childhood; (2021).

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  • Gregory L. Holmes; Child Neurology: Its Origins, Founders, Growth and Evolution; (2021).

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  • Fine Spike Timing in Hippocampal-Prefrontal Ensembles Predicts Poor Encoding and Underlies Behavioral Performance in Healthy and Malformed Brains; Cerebral Cortex; (2021).

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  • Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions; medRxiv; (2021).

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  • Brains, complex systems and therapeutic opportunities in epilepsy; Seizure; (2021).

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  • Focal dorsal hippocampal nav1.1 knock down alters place cell temporal coordination and spatial behavior; Cerebral Cortex; (2020).

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  • Microelectrode recordings in human epilepsy: a case for clinical translation; Brain Communications; (2020).

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  • Subcortical nuclei volumes are associated with cognition in children post-convulsive status epilepticus: Results at nine years follow-up; Epilepsy and Behavior; (2020).

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  • Headache in children with Sturge-Weber syndrome - Prevalence, associations and impact; European Journal of Paediatric Neurology; (2020).

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  • Current understanding of febrile seizures and their long-term outcomes; Developmental Medicine & Child Neurology; (2020).

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  • Pathophysiology of convulsive status epilepticus; Seizure; (2019).

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  • Long-term outcomes after childhood convulsive status epilepticus; Current Opinion in Pediatrics; (2019).

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  • Intelligence and memory outcomes within 10 years of childhood convulsive status epilepticus; Epilepsy and Behavior; (2019).

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  • Imaging Biomarkers for Febrile Status Epilepticus and Other Forms of Convulsive Status Epilepticus; Imaging Biomarkers in Epilepsy; (2019).

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  • Global development and adaptive behaviour in children with early-onset epilepsy: a population-based case-control study; Developmental Medicine and Child Neurology; (2019).

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  • Experiences and needs of parents of young children with active epilepsy: A population-based study; Epilepsy and Behavior; (2019).

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  • Distributed dynamic coding for spatial working memory in hippocampal-prefrontal networks; bioRxiv; (2019).

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  • Autism, ADHD and parent-reported behavioural difficulties in young children with epilepsy; Seizure; (2019).

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  • Cognitive outcomes following epilepsy in infancy: A longitudinal community-based study; Epilepsia; (2018).

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  • Symptoms of depression, anxiety, and stress in parents of young children with epilepsy: A case controlled population-based study; Epilepsy and Behavior; (2018).

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  • Parenting stress and perceived stigma in mothers of young children with epilepsy: A case-control study; Epilepsy and Behavior; (2018).

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  • Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study; The Lancet Child and Adolescent Health; (2018).

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  • Long-term behavioural outcomes after paediatric convulsive status epilepticus: a population-based cohort study; Developmental Medicine and Child Neurology; (2018).

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  • Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus; PLOS ONE; (2018).

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  • WONOEP APPRAISAL: The many facets of epilepsy networks; Epilepsia; (2018).

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  • Child and parental sleep in young children with epilepsy: A population-based case-control study; Epilepsia Open; (2018).

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  • Long-term white matter tract reorganization following prolonged febrile seizures; Epilepsia; (2017).

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  • Parent- and Teacher-Reported Symptoms of ADHD in School-Aged Children With Active Epilepsy: A Population-Based Study; Journal of Attention Disorders; (2017).

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  • Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE; Epilepsia; (2017).

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  • Environmental Enrichment Normalizes Hippocampal Timing Coding in a Malformed Hippocampus; bioRxiv; (2017).

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  • Brain abnormalities in fetuses: in-utero MRI versus ultrasound; The Lancet; (2017).

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  • Auditory processing following infantile spasms: An event-related potential study; Epilepsia; (2017).

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  • Factors associated with reported challenging behavior in young people with epilepsy and neurodevelopmental problems: Data from a specialist epilepsy center; Epilepsia Open; (2017).

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  • Network science for the identification of novel therapeutic targets in epilepsy [version 1; referees: 2 approved]; Unknown Source; (2016).

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  • Oscillation phase locking and late ERP components of intracranial hippocampal recordings correlate to patient performance in a working memory task; Frontiers in Human Neuroscience; (2016).

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  • Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus; EBioMedicine; (2016).

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  • Short-range temporal interactions in sleep; Hippocampal spike avalanches support a large milieu of sequential activity including replay; PLoS ONE; (2016).

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  • Epilepsy and autism spectrum disorders: Relatively related; Neurology; (2016).

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  • Efficacy of nonselective optogenetic control of the medial septum over hippocampal oscillations: The influence of speed and implications for cognitive enhancement; Physiological Reports; (2016).

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  • ACTH prevents deficits in fear extinction associated with early life seizures; Frontiers in Neurology; (2016).

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  • The health, education, and social care costs of school-aged children with active epilepsy: A population-based study; Epilepsia; (2015).

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  • Temporal lobe impairment in west syndrome: Event-related potential evidence; Annals of Neurology; (2015).

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  • Symptoms of anxiety and depression in school-aged children with active epilepsy: A population-based study; Epilepsy and Behavior; (2015).

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  • T2 relaxation time post febrile status epilepticus predicts cognitive outcome; Experimental Neurology; (2015).

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  • Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy; Epilepsy Research; (2015).

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  • Mechanisms responsible for cognitive impairment in epileps; Cold Spring Harbor Perspectives in Medicine; (2015).

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  • Features of developmental coordination disorder in active childhood epilepsy: A population-based study; Developmental Medicine and Child Neurology; (2015).

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  • Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures; Nature Communications; (2015).

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  • State-Dependent Differences in Functional Connectivity in Young Children With Autism Spectrum Disorder; EBioMedicine; (2015).

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  • Quantitative magnetic resonance imaging evidence for altered structural remodeling of the temporal lobe in West syndrome; Epilepsia; (2015).

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  • Factors associated with quality of life in active childhood epilepsy: A population-based study; European Journal of Paediatric Neurology; (2015).

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  • Features of autism spectrum disorder (ASD) in childhood epilepsy: A population-based study; Epilepsy and Behavior; (2015).

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  • Erratum: Status epilepticus induced spontaneous dentate gyrus spikes: In vivo current source density analysis (PLoS ONE (2015) 10:8 (e0136125) DOI: 10.1371/journal.pone.0136125); PLoS ONE; (2015).

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  • Cognition in school-aged children with "active" epilepsy: A population-based study; Journal of Clinical and Experimental Neuropsychology; (2015).

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  • Status epilepticus induced spontaneous dentate gyrus spikes: In vivo current source density analysis; PLoS ONE; (2015).

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  • Screening for mental health disorders in active childhood epilepsy: Population-based data; Epilepsy Research; (2014).

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  • Neurobehavioral comorbidities in children with active epilepsy: A population-based study; Pediatrics; (2014).

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  • Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits; Neurobiology of Disease; (2014).

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  • Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus; Neurobiology of Disease; (2014).

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  • Consequences of febrile seizures in childhood; Current Opinion in Pediatrics; (2014).

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  • Cognitive impairment in temporal lobe epilepsy: Role of online and offline processing of single cell information; Hippocampus; (2014).

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  • Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH; PLoS ONE; (2014).

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  • Academic achievement in school-aged children with active epilepsy: A population-based study; Epilepsia; (2014).

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  • A comparison of continuous video-EEG monitoring and 30-minute EEG in an ICU; Epileptic Disorders; (2014).

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  • What are the effects of prolonged seizures in the brain?; Epileptic Disorders; (2014).

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  • Hippocampal sclerosis and other forms of status epilepticus; Annals of Neurology; (2014).

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  • Enrichment and training improve cognition in rats with cortical malformations; PLoS ONE; (2013).

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  • Early developmental outcomes in children following convulsive status epilepticus: A longitudinal study; Epilepsia; (2013).

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  • Diagnosis of probable psychogenic nonepileptic seizures in the outpatient clinic: Does gender matter?; Epilepsy and Behavior; (2013).

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  • Altered short-term plasticity in the prefrontal cortex after early life seizures; Neurobiology of Disease; (2013).

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  • A population-based study of newly diagnosed epilepsy in infants; Epilepsia; (2013).

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  • Focal Scn1a knockdown induces cognitive impairment without seizures; Neurobiology of Disease; (2013).

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  • Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures; Epilepsia; (2013).

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  • Hippocampal interictal epileptiform activity disrupts cognition in humans; Neurology; (2013).

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  • Long-term seizure, cognitive, and psychiatric outcome following trans-middle temporal gyrus amygdalohippocampectomy and standard temporal lobectomy: Clinical article; Journal of Neurosurgery; (2013).

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  • Methylphenidate treatment of attention deficit hyperactivity disorder in young people with learning disability and difficult-to-treat epilepsy: Evidence of clinical benefit; Epilepsia; (2013).

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  • Speed modulation of hippocampal theta frequency correlates with spatial memory performance; Hippocampus; (2013).

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  • Short duration waveforms recorded extracellularly from freely moving rats are representative of axonal activity; Frontiers in neural circuits; (2013).

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  • Prolonged febrile seizures cause reversible reductions in white matter integrity; NeuroImage: Clinical; (2013).

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  • The role of magnetic resonance imaging in the follow-up of children with convulsive status epilepticus; Developmental Medicine and Child Neurology; (2012).

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  • Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent; NeuroImage; (2012).

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  • Seizure prognosis of patients with low-grade tumors; Seizure; (2012).

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  • Seizure outcome after extratemporal epilepsy surgery in childhood; Developmental Medicine and Child Neurology; (2012).

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  • SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome; Epilepsy and Behavior; (2012).

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  • Recognition memory is impaired in children after prolonged febrile seizures; Brain; (2012).

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  • Psychopathology in children before and after surgery for extratemporal lobe epilepsy; Developmental Medicine and Child Neurology; (2012).

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  • Prediction of seizure outcome in childhood epilepsies in countries with limited resources: A prospective study; Developmental Medicine and Child Neurology; (2012).

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  • Outcome of frontal lobe epilepsy surgery; Epilepsia; (2012).

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  • Maturation of EEG oscillations in children with sodium channel mutations; Brain and Development; (2012).

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  • Lack of efficacy of phenytoin in children presenting with febrile status epilepticus; American Journal of Emergency Medicine; (2012).

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  • Joint time-frequency analysis of EEG signals based on a phase-space interpretation of the recording process; Proceedings of SPIE - The International Society for Optical Engineering; (2012).

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  • Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats; Journal of Neuroscience; (2012).

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  • Febrile seizures and the wandering granule cell; Nature Medicine; (2012).

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  • Before Epilepsy Unfolds: Opening up the potassium door in neonatal seizures; Nature Medicine; (2012).

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  • Causes of status epilepticus in children; The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children; (2011).

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  • Death within 8 years after childhood convulsive status epilepticus: A population-based study; Brain; (2011).

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  • Maturational dynamics of hippocampal place cells in immature rats; Hippocampus; (2011).

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  • Seizure outcome in infantile spasms-A retrospective study; Epilepsia; (2011).

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  • Impaired cognition in rats with cortical dysplasia: Additional impact of early-life seizures; Brain; (2011).

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  • Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex; Epilepsy and Behavior; (2011).

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  • Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures; Journal of Neuroscience; (2011).

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  • Outcomes of childhood epilepsy at age 33 years: A population-based birth-cohort study; Epilepsia; (2011).

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  • Epilepsy surgery in children under 3 years; Epilepsy Research; (2011).

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  • Cognitive outcome after extratemporal epilepsy surgery in childhood; Epilepsia; (2011).

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  • Quantitative MRI predicts status epilepticus-induced hippocampal injury in the lithium-pilocarpine rat model; Epilepsy Research; (2010).

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  • Hippocampal interictal spikes disrupt cognition in rats; Annals of Neurology; (2010).

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  • Cognitive and behavioral comorbidities of epilepsy; Epilepsia; (2010).

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  • Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus; Experimental Neurology; (2010).

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  • Statistical Process Control (SPC)-A simple objective method for monitoring seizure frequency and evaluating effectiveness of drug interventions in refractory childhood epilepsy; Epilepsy Research; (2010).

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  • Adverse outcomes following convulsive status epilepticus in children: Relationship with hippocampal injury; Epilepsia; (2010).

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  • The effects of epilepsy surgery on emotions, behavior, and psychosocial impairment in children and adolescents with drug-resistant epilepsy: A prospective study; Epilepsy and Behavior; (2009).

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  • Treatment of community-onset childhood convulsive status epilepticus - Authors' reply; The Lancet Neurology; (2009).

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  • Phenomenology of prolonged febrile seizures: Results of the febstat study; Neurology; (2009).

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  • Socioeconomic deprivation independent of ethnicity increases status epilepticus risk; Epilepsia; (2009).

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  • Status epilepticus in the developing brain: Long-term effects seen in humans; Epilepsia; (2009).

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  • Management of convulsive status epilepticus in children; Archives of Disease in Childhood: Education and Practice Edition; (2009).

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  • Impaired everyday memory associated with encephalopathy of severe malaria: The role of seizures and hippocampal damage; Malaria Journal; (2009).

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  • Is streamlined evaluation of children for epilepsy surgery possible?; Epilepsia; (2008).

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  • Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study; The Lancet Neurology; (2008).

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  • The medical management of the epilepsies in children: conceptual and practical considerations; The Lancet Neurology; (2008).

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  • Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus; Proteomics; (2007).

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  • Outcome of convulsive status epilepticus: A review; Archives of Disease in Childhood; (2007).

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  • Clinical update: childhood convulsive status epilepticus; Lancet; (2007).

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  • Clinical trial design in status epilepticus: Problems and solutions; Epilepsia; (2007).

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  • Childhood convulsive status epilepticus: Epidemiology, management and outcome; Acta Neurologica Scandinavica; (2007).

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  • Autonomic status epilepticus in panayiotopoulos syndrome and other childhood and adult epilepsies: A consensus view; Epilepsia; (2007).

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  • 'Severe memory impairment in a child with bihippocampal injury after status epilepticus' [3]; Developmental Medicine and Child Neurology; (2007).

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  • The epidemiology of convulsive status epilepticus in children: A critical review; Epilepsia; (2007).

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  • Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes; Epilepsia; (2006).

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  • Outcome of paediatric convulsive status epilepticus: a systematic review; Lancet Neurology; (2006).

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  • Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study; Lancet; (2006).

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  • Hippocampal sclerosis in children with lesional epilepsy is influenced by age at seizure onset; Epilepsia; (2006).

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  • Cognitive competence at the onset of West syndrome [1]; Developmental Medicine and Child Neurology; (2006).

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  • Childhood convulsive status epilepticus - Authors' reply; Lancet; (2006).

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  • Buccal midazolam as rescue therapy for acute seizures; Lancet Neurology; (2005).

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  • Meningitis is a common cause of convulsive status epilepticus with fever; Archives of Disease in Childhood; (2005).

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  • Nonconvulsive status epilepticus: Epilepsy Research Foundation Workshop Reports; Epileptic Disorders; (2005).

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  • A systematic review of the epidemiology of status epilepticus; European Journal of Neurology; (2004).

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  • Inappropriate emergency management of status epilepticus in children contributes to need for intensive care; Journal of Neurology, Neurosurgery and Psychiatry; (2004).

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  • The acute management of seizures in childhood; Hospital Medicine; (2004).

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  • Hippocampal abnormalities after prolonged febrile convulsion: A longitudinal MRI study; Brain; (2003).

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  • Abnormalities in hippocampi remote from the seizure focus: A T2 relaxometry study; Brain; (2003).

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  • Magnetic resonance imaging findings within 5 days of status epilepticus in childhood; Brain; (2002).

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  • Erratum: Magnetic resonance imaging findings within 5 days of status epilepticus in childhood (Brain (2002) 125:9(1951-1959); Brain; (2002).

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  • Convulsive status epilepticus in children with intractable epilepsy is frequently focal in origin; Canadian Journal of Neurological Sciences; (2002).

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  • Quantitative magnetic resonance characterization of mesial temporal sclerosis in childhood; Neurology; (2001).

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  • Intranasal midazolam for treating febrile seizures in children [5] (multiple letters); British Medical Journal; (2001).

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  • Intranasal midazolam for treating febrile seizures in children; BMJ; (2001).

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  • The treatment of convulsive status epilepticus in children; Archives of Disease in Childhood; (2000).

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  • Buccal midazolam may be a useful alternative to rectal diazepam for treating acute seizures in refractory epilepsy: Commentary; Evidence-Based Medicine; (2000).

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  • Pharmacological management of convulsive status epilepticus in children; Developmental Medicine and Child Neurology; (1999).

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  • Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: A randomised trial; Lancet; (1999).

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  • Buccal midazolam and rectal diazepam for epilepsy (multiple letters) [2]; Lancet; (1999).

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  • Status epilepticus: Pathophysiology, epidemiology, and outcomes; Archives of Disease in Childhood; (1998).

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  • Developmental perspectives on epilepsy; Current Opinion in Neurology; (1998).

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  • Buccal absorption of midazolam: Pharmacokinetics and EEG pharmacodynamics; Epilepsia; (1998).

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  • 'Nasal rather than rectal benzodiazepines in the management of acute childhood seizures?' [1]; Developmental Medicine and Child Neurology; (1997).

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