The immune system is your body’s security system. It fights off anything that doesn’t belong, namely, viruses, bacteria, fungi and toxins.
White blood cells are an essential part of the immune system. They form in your bone marrow (the spongy material inside bones). One type of white blood cell is called a lymphocyte. There are two types of lymphocytes:
In acute lymphoblastic leukemia (ALL), cancer affects how these lymphocytes develop so they can’t do their job right. But with CAR T-cell therapy for leukemia, doctors reprogram the healthy T-cells to kill leukemia cells.
CAR T-cell therapy is a revolutionary new treatment for leukemia. It is a combination of gene therapy and immunotherapy.
During leukemia CAR T-cell therapy:
Once in your child’s body, the new T-cells grow in number and get rid of the cancer. And because these cells stay in your child’s body for months, maybe years, they may provide long-term protection.
Together, we can achieve the best possible outcome for your patient.Refer a Patient
Our doctors have special expertise in this breakthrough therapy. For example, Nemours Children’s Hospital, Delaware is among a small group of hospitals designated as a CAR-T Center. We earned this designation in 2018 because of our:
Children in Florida can get this lifesaving treatment at Nemours Children’s Health, Jacksonville and our partner Wolfson’s Children's Hospital in Jacksonville. The Ronald McDonald House of Delaware and Ronald McDonald House of Jacksonville are nearby for families that need a place to stay during treatment.
A transplant coordinator supports and guides you from the start. Your coordinator is a familiar face throughout the process, on-hand to:
We have many pediatric leukemia experts and locations — find the care closest to you:
Both bone marrow transplants (also known as stem cell transplants) and CAR T-cell therapy effectively treat childhood leukemia. But there are some differences.
Doctors can use bone marrow transplants to treat several types of childhood leukemia, including ALL, acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Currently, doctors can only use CAR T-cell therapy to treat B-cell ALL. B-cell ALL is the most common type of leukemia that relapses.
CAR T-cell therapy tends to have fewer side effects than stem cell transplants because:
Because of ongoing leukemia clinical trials, the list of children who can get CAR T-cell therapy grows each year. Children with other kinds of leukemia or lymphoma may also be able to get this therapy in the future as we continue to prove its safety and effectiveness.
In 2017, the FDA approved the use of CAR T-cell therapy in children with B-cell ALL that has relapsed. If your child has been diagnosed with B-cell ALL that has relapsed or not responded to other treatments, they may be eligible for CAR T-cell therapy.
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