Tetralogy of Fallot

Skip Navigation
Back to top

Tetralogy of Fallot


Early Diagnosis and Expert TOF Care


Happy little girl after treatment at Nemours for Tetralogy of Fallot.

Tetralogy of Fallot — or TOF — is a rare, congenital (present at birth) condition caused by a combination of four heart defects. As a result, the defects change the way blood flows through the heart and to the lungs, so less oxygen-rich blood is carried to the body. This means TOF is repaired through surgery soon after a baby is born or early in infancy. In many cases, TOF can be diagnosed during pregnancy so care can begin right away. 

At Nemours, we offer leading-edge capabilities to detect heart problems early, including babies still in the womb — giving children the best chance. If your child is diagnosed with TOF, you can trust the pediatric heart care in our Nemours Cardiac Center. Our board-certified, fellowship-trained pediatric cardiologists and cardiothoracic surgeons (specialists in surgical procedures of the chest, including the heart and lungs) are here to answer your questions, address your concerns, and offer treatment options. Our cardiac teams offer the latest in research-backed care, delivered with compassion.

Learn More About Tetralogy of Fallot

Services We Offer for Tetralogy of Fallot

Services We Offer for Tetralogy of Fallot


The expert teams in our Nemours Cardiac Center locations offer a full range of pediatric heart care to diagnose and treat TOF. Services vary by specialist and location, but may include:

  • Fetal Diagnostics. Early detection in our perinatology and fetal medicine centers help us diagnose congenital heart defects and make a treatment plan for when your baby’s born. 
  • Cardiac Catheterization. A procedure used to diagnose or treat cardiac problems by inserting a thin plastic, flexible tube (called a “catheter”) into an artery or vein, and  threading it through the bloodstream into the heart and its large blood vessels. 
  • Cardiac Diagnostics and Kid-Friendly Imaging. State-of-the-art, noninvasive and minimally invasive tests for kids of all ages. 
  • Genetics Counseling. Although the cause isn’t always known, TOF can be inherited (passed from parent to child) or part of other genetic conditions like Down syndrome. 
  • Heart Surgery. All children with TOF will require open-heart surgery to correct the condition, although the timing of the surgery will vary based on your child’s situation. 
Why Choose Us for TOF Repair & Care

Why Choose Us for TOF Repair & Care


World-class pediatric heart care requires the compassion to understand your family's journey, and the expertise to heal even the most complex conditions. Our Nemours Cardiac Center teams are highly experienced at caring for children born with tetralogy of Fallot. Even newborns only hours or days old can be quickly diagnosed and treated right when it matters the most. We specialize in early detection and repair of congenital heart defects (also known as congenital heart disease). Our goal is to guide your family from diagnosis through treatment, and to help you transition into adult care — so your child can enjoy the best quality of life possible.

Learn More About Why to Choose Us »

Regional Highlights of Our Tetralogy of Fallot Repair & Care

Services, programs, facilities and care teams differ at each location. Call for details.

Ranked in best children's hospitals for cardiac care.

We offer care for newborns and children with tetralogy of Fallot at Nemours/Alfred I. duPont Hospital for Children (Wilmington, Del.) and select Nemours duPont Pediatrics locations.

The Nemours Cardiac Center located at Nemours/Alfred I. duPont Hospital for Children is ranked among the best children’s hospitals in the nation for pediatric cardiology and heart surgery by U.S. News and World Report.

We offer care for newborns and children with tetralogy of Fallot at Nemours Children’s Hospital (Orlando) and select Nemours Children’s Specialty Care locations.  

Our renowned pediatric cardiology and cardiothoracic surgery team at the Nemours Cardiac Center in Central Florida offers inpatient, critical and surgical care at Nemours Children’s Hospital in Orlando — including dedicated cardiac anesthesiologists and state-of-the-art cardiac intensive care unit (CICU). 

A dedicated cardiac program for kids with Down syndrome. Since about half of the babies born with Down syndrome also have congenital heart defects, our Cardiac Center experts work with our on-site neuromuscular specialists to evaluate and treat heart defects — including atrioventricular and ventricular septal defects and tetralogy of Fallot. 

We offer tetralogy of Fallot care at Nemours Children’s Specialty Care, Pensacola and our hospital affiliate, West Florida Healthcare, with outpatient and follow-up appointments also available at select Nemours Children’s Specialty Care locations.

Our Nemours Cardiac Center in Pensacola is home to one of the few accredited pediatric transthoracic and fetal echocardiography labs in Florida and, if needed, can facilitate the transfer of extremely ill children between our Nemours Cardiac Center locations (e.g., to Nemours Children’s Hospital).  

Patient Stories

Patient Stories


Capucine tells her story of care at Nemours for Tetralogy of Fallot.

Sometimes the best support and peace of mind comes from families who’ve been there. Meet some of the inspiring kids we’ve been honored to treat.

See Patient Stories »

research icon

Research & Clinical Trials

At Nemours, we’re actively researching new approaches for childhood disease prevention, diagnosis and treatment.

kidshealth icon

KidsHealth Library

Learn more about your child’s medical condition from the experts at Nemours’ KidsHealth.