Osteogenesis Imperfecta (OI)

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Osteogenesis Imperfecta (OI)


Expert Care for Kids With Brittle Bone Disease


Three children being treated at Nemours for osteogenesis imperfecta

Osteogenesis imperfecta (OI), also called “brittle bone disease,” is a rare genetic disorder that affects the formation and strength of bones. Children born with OI have bones that break easily, often with little or no obvious cause. With the proper medical treatment and supportive care, most kids with OI can reach their full potential. At Nemours, our goal is to help kids build bone mass and muscle strength, manage their symptoms, and be as active as possible.

Learn More About Osteogenesis Imperfecta

Services We Offer for Osteogenesis Imperfecta

Services We Offer for Osteogenesis Imperfecta


Some kids will need more extensive care than others, and our services may vary depending upon the location and doctor you see:

Why Choose Us for Osteogenesis Imperfecta Treatment

Why Choose Us for Osteogenesis Imperfecta Treatment


Nemours Children’s Health System has been recognized for delivering advanced pediatric orthopedic care since 1940. Our Osteogenesis Imperfecta Program in Wilmington, Delaware is one of the world’s leading programs for the treatment of OI. And because we’re a system, Nemours offers a dedicated team of experts in more than 30 medical and surgical specialties who come together to create a roadmap of care for children with this rare genetic disorder. We also offer: 

  • international leaders in pediatric research and care in orthopedics
  • world class facilities and innovative surgical techniques 
  • coordinated care for your child and family that includes support services, including help with community resources 

Learn More About Why to Choose Us » 

Regional Osteogenesis Imperfecta Highlights

Services, programs, facilities and care teams for osteogenesis imperfecta (OI) differ at each location. Call for details.

Chosen among very best children's hospitals for orthopedics care.

We offer diagnosis and ongoing care from the top experts in the field in our Osteogenesis Imperfecta Program at Nemours/Alfred I. duPont Hospital for Children (Wilmington, Del.).

As members of the Brittle Bones Disorders Consortium (BBD) , we offer the latest in research-based care. 

We offer complete orthopedic care for children with osteogenesis imperfecta at Nemours Children’s Hospital (Orlando), with outpatient appointments at select Nemours Children’s Specialty Care locations.

Our Medically Complex Coordination Clinic is available at Nemours Children’s Hospital and helps families and pediatricians coordinate care for children with complex conditions like OI. 

We offer a comprehensive inpatient and outpatient rehabilitation program at Nemours Children’s Hospital. It’s one of only four multispecialty pediatric inpatient rehabilitation programs in all of Florida — and the only one in Central Florida. 

We offer orthopedic care for children with osteogenesis imperfecta at Nemours Children’s Specialty Care, Jacksonville and our hospital affiliate, Wolfson Children’s Hospital, with outpatient and follow-up appointments available at select Nemours locations.

We offer orthopedic care for children with osteogenesis imperfecta at Nemours Children’s Specialty Care, Pensacola and our hospital affiliate West Florida Healthcare, with outpatient appointments available at select Nemours locations.

Patient Stories

Patient Stories


Read Isaiah's story about getting treated for osteogenesis imperfecta at Nemours.

Sometimes the best support and peace of mind comes from families who’ve been there. Meet some of the inspiring kids we’ve been honored to treat.

See Patient Stories »

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Research & Clinical Trials

At Nemours, we’re actively researching new approaches for childhood disease prevention, diagnosis and treatment.

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KidsHealth Library

Learn more about your child’s medical condition from the experts at Nemours’ KidsHealth.